NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS by Fan Z, Ge Q, Ni B, Zhang J, Du T, Xu H, Duan Z, Zhang S, Wang C, Xue J, Ling F, Chen Z, Shen B, Wei Z

“…This study aimed to investigate the effects of nuclear factor erythroid 2-related factor 2 (NRF2) on IC/BPS and the potential molecular mechanisms.Methods: Bladder mucosal biopsies from IC/BPS patients were subjected to RT-qPCR and immunoblotting to quantify NRF2 mRNA/protein expression. …”
Get full text

AI in Home Care—Evaluation of Large Language Models for Future Training of Informal Caregivers: Observational Comparative Case Study by Clara Pérez-Esteve, Mercedes Guilabert, Valerie Matarredona, Einav Srulovici, Susanna Tella, Reinhard Strametz, José Joaquín Mira

“…Furthermore, it seeks to identify specific domains where LLMs show the most promise and where improvements are necessary to optimize their reliability for caregiver training. MethodsAn observational, comparative case study evaluated 3 LLMs—GPT-3.5, GPT-4o, and Microsoft Copilot—in 10 home care scenarios. …”
Get full text

The impact of the universities closure on physical activity and academic performance in physical education in university students during the COVID-19 pandemic by Aleksander Yu. Osipov, Tatyana I. Ratmanskaya, Elena A. Zemba, Vladimir Potop, Mikhail D. Kudryavtsev, Roman S. Nagovitsyn

“…The purpose of the research was to assess overall and sport/fitness PA level and academic performance in PE in a sample of university students pre- to post-cancellation of face-to-face PE classes due to the COVID-19 pandemic. Material and Methods. Participants (n=209) – university students (19-20 years old). …”
Get full text

Predictive Scores for Identifying Chronic Opioid Dependence After General Anesthesia Surgery by Sun M, Chen WM, Lu Z, Lv S, Fu N, Yang Y, Wang Y, Miao M, Wu SY, Zhang J

“…Mingyang Sun,1,2,* Wan-Ming Chen,3,4,* Zhongyuan Lu,1,2 Shuang Lv,1,2 Ningning Fu,1,2 Yitian Yang,1,2 Yangyang Wang,1,2 Mengrong Miao,1,2 Szu-Yuan Wu,5– 11 Jiaqiang Zhang1,2 1Department of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 2Academy of Medical Sciences of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 3Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei, Taiwan; 4Artificial Intelligence Development Center, Fu Jen Catholic University, Taipei, Taiwan; 5Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan; 6Big Data Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 7Division of Radiation Oncology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 8Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan; 9Cancer Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan, Taiwan; 10Centers for Regional Anesthesia and Pain Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; 11Department of Management, College of Management, Fo Guang University, Yilan, Taiwan*These authors contributed equally to this workCorrespondence: Szu-Yuan Wu, College of Medical and Health Science, Asia University, Taichung, Taiwan; Director, Big Data Center, Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, No. 83, Nanchang St., Luodong Township, Yilan County, 265, Taiwan, Email szuyuanwu5399@gmail.com Jiaqiang Zhang, Department of Anesthesiology and Perioperative Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou, Henan, 450003, People’s Republic of China, Email jiaqiang197628@163.comPurpose: To address the prevalence and risk factors of postoperative chronic opioid dependence, focusing on the development of a predictive scoring system to identify high-risk populations.Methods: We analyzed data from the Taiwan Health Insurance Research Database spanning January 2016 to December 2018, encompassing adults undergoing major elective surgeries with general anesthesia. …”
Get full text

Activation of TLR4/CCL2 in Intact Neurons Drives Radicular Injury-Induced Global Nerve Trunk Hypersensitivity in Radiculopathy Preclinical Models by Tong SH, Zhou J, Ye F, Ding P, Mei JL, Liao P, Lu YF, Zong Y, Gao CA, Zhang SY, Gao JJ, Liu DL, Huang YG

“…However, the underlying mechanisms remain unclear.Methods: An L5 spinal nerve compression rat model was established. …”
Get full text

The effects of normal and interrupted sleep combined with acute caffeine supplementation on some immune system indices and anaerobic power in male athletes by Mohammad hossein Hashemzadeh, Farhad Rahmaninia, Payam Saidie

“…In the current study, the effects of normal and interrupted sleep combined with acute caffeine supplementation on some immune system indices and anaerobic power in male athletes were examined.Materials and Methods: This semi-experimental study was conducted using a randomized design. …”
Get full text

Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…Xiangran Gu,1,* Yuan Chen,2,* Xinyue Hu,1,* Yunhui Li,3 Renlong Zhu,2 Hongxu Li,1 Zhengrong Yuan,1 Yajie Wang2,3 1College of Biological Sciences and Technology, Beijing Forestry University, Beijing, People’s Republic of China; 2Department of Clinical Laboratory, Peking University Ditan Teaching Hospital, Beijing, People’s Republic of China; 3Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengrong Yuan, College of Biological Sciences and Technology, Beijing Forestry University, No. 35 Tsinghua East Road, Haidian District, Beijing, 100083, People’s Republic of China, Email zryuan@bjfu.edu.cn Yajie Wang, Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China, Email wangyajie@ccmu.edu.cnObjective: This study aimed to identify autophagy-related genes (ARGs) with prognostic significance in hepatocellular carcinoma (HCC) using bioinformatics and survival analysis.Materials and Methods: ARGs were sourced from multiple references, including the Human Autophagy Database (HADb), relevant literatures, the Gene Set Enrichment Analysis (GSEA), and a final list was confirmed after eliminating duplicate entries. …”
Get full text

Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection by Andrea A. Berry, Thomas L. Richie, L. W. Preston Church, Matthew B. Laurens, Colleen Boyce, Natasha KC, Sudhaunshu Joshi, Abra Rachida Koudjra, Lauryn Butler, Mei-Chun Chen, Yonas Abebe, Tooba Murshedkar, Eric R. James, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman, Kirsten E. Lyke

“…Attenuated P. falciparum sporozoites (PfSPZ) are being developed as a traveller’s vaccine and to fulfill WHO’s call for high-level efficacy in endemic countries to support malaria elimination. Methods PfSPZ Vaccine, comprised of radiation-attenuated PfSPZ, was compared with normal saline placebo in a randomized, double-blind trial targeting 60 malaria-naive US adults to assess safety, tolerability, immunogenicity, and efficacy against heterologous controlled human malaria infection three and twelve weeks after immunization. …”
Get full text

Correlation of Novel Inflammation Index with Postoperative Acute Kidney Injury in Patients with Joint Arthroplasty: A Retrospective Cohort Study by Yan YT, Liu R, Liu J, Zhang WJ, Wang S, Tang TY, Lei YQ, Zhu XY, Liu KX, Zheng QJ, Liu HM

“…This study investigated the association between novel inflammation indices and postoperative AKI.Methods: This retrospective cohort study included 1434 patients who underwent hip or knee arthroplasty, with 1225 patients comprising the complete case analysis dataset. …”
Get full text

Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice by Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X

“…Xiaomin Ye,1,2,* Shaozhao Zhang,1,2,* Xiangbin Zhong,1,2 Miaohong Li,1,2 Menghui Liu,1,2 Xiaodong Zhuang,1,2 Xinxue Liao1,2 1Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinxue Liao, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13903063724, Fax +86-020-28823388, Email liaoxinx@mail.sysu.edu.cn Xiaodong Zhuang, Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, People’s Republic of China, Tel +86-13760755035, Email zhuangxd3@mail.sysu.edu.cnBackground: Real-world evidence about adherence to proprotein convertase subtilisin/kexin type-9 inhibition (PCSK9i) is needed in Chinese population.Objective: We aimed to evaluate the adherence patterns using anti-PCSK9 monoclonal antibody in Chinese clinical practice and explored the association between adherence to PCSK9i and low-density lipoprotein cholesterol (LDL-C) reduction ratio and variability.Methods: A total of 5373 patients initiating PCSK9i in the First Affiliated Hospital of Sun Yat-sen University were included as sub-analysis of the RED-CARPET registry. …”
Get full text

Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Nor... by Ramon da Costa Saavedra, Martha Suely Itaparica de Carvalho Santiago, Maria da Glória Lima Cruz Teixeira, Maria Bernadete de Cerqueira Antunes, Rejane Christine de Sousa Queiroz, Luisa Helena de Oliveira Lima, Alberto Novaes Ramos Jr, Anderson Fuentes Ferreira, Adjoane Mauricio Silva Maciel, Jaqueline Caracas Barbosa, Ana Paula França, Carla Magda Allan Santos Domingues, José Cássio de Moraes, Adriana Ilha da Silva, Alberto Novaes Ramos Jr., Ana Paula França, Andrea de Nazaré Marvão Oliveira, Antonio Fernando Boing, Carla Magda Allan Santos Domingues, Consuelo Silva de Oliveira, Ethel Leonor Noia Maciel, Ione Aquemi Guibu, Isabelle Ribeiro Barbosa Mirabal, Jaqueline Caracas Barbosa, Jaqueline Costa Lima, José Cássio de Moraes, Karin Regina Luhm, Karlla Antonieta Amorim Caetano, Luisa Helena de Oliveira Lima, Maria Bernadete de Cerqueira Antunes, Maria da Glória Lima Cruz Teixeira, Maria Denise de Castro Teixeira, Maria Fernanda de Sousa Oliveira Borges, Rejane Christine de Sousa Queiroz, Ricardo Queiroz Gurgel, Rita Barradas Barata, Roberta Nogueira Calandrini de Azevedo, Sandra Maria do Valle Leone de Oliveira, Sheila Araújo Teles, Silvana Granado Nogueira da Gama, Sotero Serrate Mengue, Taynãna César Simões, Valdir Nascimento, Wildo Navegantes de Araújo

“…ABSTRACT Objective To estimate vaccination coverage and analyze sociodemographic factors associated with non-vaccination in children born in 2017 and 2018 in the state capitals of Northeast Brazil. Methods A household survey using cluster sampling was conducted from 2020-2022 to estimate vaccination coverage and hesitancy. …”
Get full text

Improvement in long-term survival with mesenchymal stem cell transplantation in systemic sclerosis patients: a propensity score-matched cohort study by Wenyi Yuan, Mian Liu, Dapeng Yang, Yirui Shi, Zhikang Wang, Xuan Cao, Jun Liang, Linyu Geng, Huayong Zhang, Xuebing Feng, Ziyi Jin, Dandan Wang, Lingyun Sun

“…While several studies have investigated the therapeutic potential of mesenchymal stem cell transplantation (MSCT), the clarity of its long-term outcomes for SSc patients is still lacking. Methods Data on MSCT were extracted from the medical records of inpatients at Nanjing Drum Tower Hospital between January 2013 and December 2022. …”
Get full text

Proportional representation and incidence rate of repeat visits in ethnic minorities compared to native Dutch people under the age of 25 years in the Netherlands by Y.J. Evers, A. Verhaegh, A. Ibrahim, C. Peters, N.H.T.M. Dukers-Muijrers, R. Reijs, C.J.P.A. Hoebe

“…In this study, we aimed to determine the proportional representation of first- and second generation EMs under 25 years at Dutch Sexual Health Centers (SHCs) compared to native Dutch citizens. Methods: In this retrospective cohort study, coded health records data of 270,927 persons in the age group of 15 till 24 years visiting SHCs between 2016 and 2021 were included. …”
Get full text

Effect of traditional Chinese medicine combined with conventional Western medicine for patients with severe/very severe chronic obstructive pulmonary disease: a multi-center, rando... by Jiansheng Li, Yang Xie, Minghang Wang, Suyun Li, Xuefeng Yu, Nianzhi Zhang, Zhengang Zhu, Wei Zhang, Jihong Feng, Zikai Sun, Lin Lin, Zhijia Sun, Hailong Zhang, Xueqing Yu

“…This study aimed to evaluate the clinical efficacy of comprehensive therapy based on TCM patterns for patients with stable, severe to very severe COPD. Methods A multicenter, randomised, double-blind, placebo-controlled trial was conducted. …”
Get full text

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study by Marcio Steinbruch, Carlos Nunes, Romualdo Gama, Renato Kaufman, Gustavo Gama, Mendel Suchmacher Neto, Rafael Nigri, Natasha Cytrynbaum, Lisa Brauer Oliveira, Isabelle Bertaina, François Verrière, Mauro Geller

“…The most commonly used one is diosmin, available in a pure semisynthetic form or as a micronized purified flavonoid fraction. Patients and Methods. The primary objective of this single-blind, randomized, parallel-group, prospective study was to assess the clinical noninferiority of nonmicronized diosmin 600 mg once daily (D-group) compared to micronized diosmin 900 mg plus hesperidin 100 mg once daily (D/H-group) over a 6-month treatment period. …”
Get full text

Diagnostic work-up of lipomatous tumors: a decision-making analysis among European sarcoma centers by Ali Naimi, Paul Martin Putora, Christian Rothermundt, Antonia Digklia, Jose Manuel Asencio, Sylvie Bonvalot, Florian Bösch, Anant Desai, Amer James Durrani, Haim Gutman, Daphne Hompes, Jens Jakob, Wolfram Trudo Knoefel, Elisabetta Pennacchioli, Piotr Rutkowski, Winan J. van Houdt, Barbara L. van Leeuwen, Stephan Waelti, Tim Steffen Fischer, Stefan Markart, Simon Wildermuth, Tobias Johannes Dietrich

“…The aim of this work was to compare standard operating procedures (SOPs) for the diagnostic management of lipomatous soft-tissue tumors among European academic centers. Methods Experts of the Soft Tissue and Bone Sarcoma Group of the European Organization for Research and Treatment of Cancer were asked for their SOPs in the diagnosis of adipocytic soft-tissue tumors in an otherwise healthy patient. …”
Get full text

Ensemble Computational Intelligent for Insomnia Sleep Stage Detection via the Sleep ECG Signal by Pragati Tripathi, M. A. Ansari, Tapan Kumar Gandhi, Rajat Mehrotra, Md Belal Bin Heyat, Faijan Akhtar, Chiagoziem C. Ukwuoma, Abdullah Y. Muaad, Yasser M. Kadah, Mugahed A. Al-Antari, Jian Ping Li

“…The traditional insomnia detection methods are time-consuming, cumbersome, and more expensive because they demand a long time from a trained neurophysiologist, and they are prone to human error, hence, the accuracy of diagnosis gets compromised. …”
Get full text

Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding by Yongpeng Xie, Yao Yan, Qixiang Hong, Hui Zheng, Lijuan Cao, Xiaoming Li, Songqiao Liu, Hui Chen

“…Understanding HTE is crucial for tailoring SUP to individual treatment. Methods This cohort study included patients admitted to intensive care unit (ICU) with at least one risk factor for clinically important gastrointestinal bleeding (GIB). …”
Get full text

Using Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania by Simon Martin Nzilibili, Hellen Maziku, Awet Araya, Ruthbetha Kateule, Millenium Anthony Malamla, Suna Salum, Furaha Kyesi, Lotalis Gadau, Tumaini Menson Haonga, Florian Tinuga, Rashid Mfaume, Zaitun Hamza, Georgina Joachim, Alice Geofrey Mwiru, Alex Benson, Oscar Kapela, Ona Machangu, Norman Jonas, Ntuli Kapologwe

“…As a result, 67,145 houses, equal to 104%, were reached, surpassing the initial target of 64,800 houses, and 131,088 families, equal to 83% of the targeted 156,995 households, were sensitized through a home-to-home campaign approach. …”
Get full text

Study of Concentration of Angiotensin-Converting Enzyme 2 Receptor Proteins in Different Age-groups and Genders with Reference to Susceptibility toward Severe Acute Respiratory Syn... by Shareef M Buvvaji, Vinod Joshi, Bennet Angel, Annette Angel, Poorna Khaneja, Monika Dheer, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Ramesh Joshi, Ambreen S Khan, Nuzhat M Peer, Khushbu Kumari, Reshu Chauhan, Aarya Chitransh

“…The present study aimed to find whether age-specific disease severity was due to different concentrations of ACE2 in the patients. Materials and methods: Nasopharyngeal swab samples of different age-groups and gender from infected COVID-19 patients and healthy individuals were subjected to Enzyme-Linked Immunosorbent Assay (ELISA) for quantitative estimation of ACE2 in the upper respiratory tract. …”
Get full text