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    Serum interleukin-18 level in patients with antineutrophil cytoplasmic antibodies associated vasculitis and implication by CAI Juan, WANG Wei-li, HUANG Xin, WANG Yuan, TANG Sha, ZHANG Jing-bo

    Published 2015-01-01
    “…Objective To investigate serum interleukin-18(IL-18) level in patients with antineutrophil cytoplasmic antibodies(ANCA) associated vasculitis(AAV) and the implication in AAV.Methods Sera and clinical data were obtained from patients with AAV,mesangial proliferative glomerulonephritis(mild-MsPGN) and healthy controls(HCs).The IL-18 levels were measured by enzyme linked immunosorbent assay(ELISA).The correlation between the levels of serum IL-18 and the AAV activity index birmingham vasculitis active scoring system(BVAS),C-reaction protein(CRP),erythrocyte sedimentation rate(ESR),estimated glomerular filtration rate(e-GFR),serum creatinine(SCr)levels and 24-h urinary protein quantity(24 h-UPQ) was analyzed by pearson correlation analysis.Receiver operating characteristic curves(ROC) of serum IL-18,CRP and ESR levels were analyzed.Results(l)The serum IL-18 levels in patients with active AAV[(183.85 + 57.0) ng/L]were increased significantly as compared with inactive AAV[(92.0 ± 34.29) ng/L,P<0.05],mild-MsPGN[(63.0± 17.7) ng/L,P<0.01]and HCs[(39.2 ± 6.3) ng/L,P<0.01];(2) There was a positive correlation between the serum levels of IL-18 and the index of BVAS(r = 0.572,P<0.01) and ESR levels(r= 0.394,P<0.05),respectively.However,there was no correlation between the levels of serum IL-18 and the levels of CRP,e-GFR,SCr and 24 h-UPQ(r = 0.117,-0.25,0.29,0.20,respectively,P>0.05);(3)ROC revealed that the level of serum IL-18 was superior to the level of CRP or ESR to distinguish active and inactive AAV.Conclusions The levels of IL-18 were elevated significantly in active AAV patients,suggesting IL-15 may be involved the pathophysiology of AAV.…”
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    Spatial pattern and distribution of urban farms and climate change adaptation implications in urban Ghana by Godwin K. Naazie, Isaac Agyemang, Anthony M. Tampah-Naah

    Published 2024-12-01
    “…The study employed a mixed-methods research approach. Geospatial data was collected using the Global Positioning System. …”
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    Epigenetic evolution and clinicopathological implications of distinct DNA methylation profiles in pancreatic ductal adenocarcinoma by Keiichiro Kitahama, Yu-Jui Ho, Kaishi Satomi, Takahiro Shibayama, Kiyotaka Nagahama, Kouki Ohtsuka, Hiroaki Ohnishi, Yoshihiro Sakamoto, Junji Shibahara, Akimasa Hayashi

    Published 2025-08-01
    “…Gene set enrichment analysis with TCGA gene expression data demonstrated the upregulation of DNA repair and MYC target genes in T2 samples (FDR q < 0.001). …”
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    Clinical Implications of ECG in Patients Presenting to ED with Drug-overdose and Organo-phosphorous Poisoning by Jagadesha Selvan, Darpanarayan Hazra, Gina M. Chandy, Priya Ganesan

    Published 2025-01-01
    “…This study aims to determine the clinical implications of an electrocardiogram (ECG) in patients with an alleged history of DSH (drug overdose and/or OP poisoning) presenting to the ED. …”
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