Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach by Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee

“…Based on the PK and genotype data, a parent‐metabolite joint population PK model including a well‐stirred liver compartment was developed using a nonlinear mixed‐effect modeling approach. …”
Get full text

Technological Solutions to Improve Inpatient Handover in the Era of Artificial Intelligence: Scoping Review by Louis Agha-Mir-Salim, Isabelle Rose Alberto, Nicole Rose Alberto, Leo Anthony Celi, Pia Gabrielle Alfonso, Rachel Hicklen, Katelyn Legaspi, Rajiv Hans Menghrajani, Faye Yu Ng, Patricia Therese Pile, Christopher M Sauer

“…Abstract and full-text screenings were conducted independently by 2 reviewers, with conflicts resolved by a third reviewer. Data extraction and synthesis were performed by multiple authors and cross-reviewed for accuracy. …”
Get full text

Safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral allosteric TYK2 inhibitor ESK‐001 using a randomized, double‐blind, placebo‐controlled study design by Sibel Ucpinar, Joyce K. Kwan, Joshua D. Hoffman, Mera K. Tilley, Jeffrey A. Douglas, Roman G. Rubio, Ruixiao Lu, Philip A. Nunn, Claire L. Langrish

“…By correlating PK exposure data with PD readouts, a strong PK/PD relationship was demonstrated. …”
Get full text

How does livelihood capital influence the green production behaviors among professional grain farmers cultivating high-quality rice? by Bin Zhang, Wenyi Mao, Zhen Hu, Yingshu Cai, Ning Xie, Zhenlin Weng, Zhenlin Weng

“…By analyzing data from 655 professional grain farmers in Jiangxi Province and utilizing the ordered logit model, we analyzed and validated the influence of livelihood capital on the green production behaviors. …”
Get full text

Heterogeneity in Danish lung choirs and their singing leaders: delivery, approach, and experiences: a survey-based study by Daniel Bech Rasmussen, Anders Løkke, Uffe Bodtger, Mette Kaasgaard, Ingrid Charlotte Andersen, Ole Hilberg, Peter Vuust

“…Further studies are needed to develop and distribute a preferred methodological approach.Trial registration number This study is linked to clinical trial number NCT03280355 and was performed prior to data collection and results of the clinical trial…”
Get full text

Association between human herpesvirus infections and dementia or mild cognitive impairment: a systematic review protocol by Judith Breuer, Liam Smeeth, Basil H Ridha, Martin Rossor, Charlotte Warren-Gash, Harriet Forbes, Angelique Mavrodaris, Andrew C Hayward, Sara L Thomas

“…Titles, abstracts and full-text screening will be conducted by two researchers independently. Data will be extracted systematically from eligible studies using a piloted template. …”
Get full text

Clinical Summary of 186 Cases of Orbital Autologous Fat Injection Transplantation Safely Implemented by Boosters by LIU Ping, LIU Yi, SONG Mei, YANG Fuxiu, LI Xiaoxiao, WANG Yinping

“…ObjectiveTo summarize the clinical effect of using boosters for orbital autologous fat injection transplantation.MethodsA retrospective analysis was conducted on the clinical data of patients who underwent orbital fine autologous fat injection and transplantation at the Burn and Plastic Surgery Department of the 940th Hospital of the PLA Joint Logistics Support Force from January 2019 to December 2023. …”
Get full text

Meta-Ensemble Learning for Heart Disease Prediction: A Stacking-Based Approach With Explainable AI by Mehwish Naz, Aqsa Khalid, Abdul Hameed, Rabia Taj, Waleed Mumtaz, Faiz Abdullah Alotaibi, Mrim M. Alnfiai

“…The work demonstrates a robust machine learning framework for classifying heart disease on three widely used benchmark datasets for heart disease such as Heart_2020_Cleaned, Heart Statlog Cleveland Hungary, and Cardio Train. A comparative analysis was conducted across these datasets to evaluate model performance under varying data characteristics. …”
Get full text

Advances in sustainable additive manufacturing: a systematic review for construction industry to mitigate greenhouse gas emissions by Oluwole Joseph Oladunni, Oluwole Joseph Oladunni, Carman K. M. Lee, Idowu David Ibrahim, Oludolapo Akanni Olanrewaju

“…Background and ObjectiveAdditive Manufacturing (AM), driven by digital 3D design data, is a transformative technology that holds significant potential to revolutionize the construction industry. …”
Get full text

Assessment of uteroplacental vascularisation in early first-trimester pregnancy with contrast-enhanced ultrasound and 3D power Doppler angiography: protocol for a prospective, cros... by Olivier Morel, Charline Bertholdt, Marie-Laure Eszto, Mathilde Tournier, Gabriela Hossu, Naoual Mellouki, Aboubaker Cherifi

“…The secondary objectives are to: (1) describe the indicators of vascularisation of the placenta (intervillous space) and the myometrium at the three gestational ages, measured by CEUS and three-dimensional power Doppler (3DPD) angiography; (2) compare the diagnostic performance of CEUS and 3DPD for the demonstration and quantification of uteroplacental vascularisation and (3) establish a biological collection of placentas to increase knowledge about placental development and functions during pregnancy.Methods and analysis This is a prospective, cross-sectional, multicentre and non-randomised open study. …”
Get full text

General practitioners’ perceptions of interprofessional collaboration in Belgium: a qualitative study by Hubert Jamart, Dionne Kringos, Dajana Tare, Aishwarya Chokshi, Anouk Tans, Isabelle Heymans, Ann Van den Bruel, Jean-Luc Belche

“…A structured focus group guide was designed, incorporating three scenarios to examine tasks commonly encountered in GP practices. Data analysis was conducted using a codebook developed through an inductive approach. …”
Get full text

Self-delivering RNAi immunotherapeutic PH-762 silences PD-1 to generate local and abscopal antitumor efficacy by Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Ramdane Guemiri, Andrew Boone, Deborah Bellet, Brianna Rivest, James Cardia, Caroline Robert, Simon P. Fricker

“…This study presents preclinical proof-of-concept for PH-762, an INTASYL designed to silence PD-1, currently in clinical development for advanced cutaneous malignancies (ClinicalTrials.gov#NCT06014086).Methods and analysisPH-762 pharmacology was characterized in vitro, and in vivo antitumor efficacy was evaluated using a murine analogue (mPH-762) in syngeneic tumor models with varying PD-1 responsiveness. …”
Get full text

Induction of Cellular Immune Response by DNA Vaccine Coexpressing E. acervulina 3-1E Gene and Mature CHIl-15 Gene by Dexing Ma, Chunli Ma, Mingyang Gao, Guangxing Li, Ze Niu, Xiaodan Huang

“…In comparison with pcDNA3.1-immunized and control groups, lymphocyte proliferation, percentage of CD8α+ cell, and levels of ChIL-2 and ChIFN-γ transcripts in the group immunized with pcDNA-3-1E-linker-mChIL-15 were significantly increased on day 6 following challenge (P<0.05, P<0.01, and P<0.01, resp.). Our data suggested that the fusion antigen 3-1E-linker-mChIL-15 could be a potential candidate for E. acervulina vaccine development.…”
Get full text

Patients' and Physicians' Experience With and Acceptability of a Telemedicine Cabin: Mixed Methods Study by Caroline Villela Galvão de França, Paola Boaro Segalla, Felipe Sebastião de Assis Reis, José Ricardo Silveira Pereira, Alexandre Oliveira de Mattos, Roberta de Moura Ferron, Cleyton Zanardo de Oliveira, Jéssica Bassani Borges, Lilian Quintal Hoffmann, Edmundo Di Giaimo Caboclo

“…In both phases, participants completed screening questionnaires (to assess the eligibility criteria), a socioeconomic demographic questionnaire before using the cabin, and a questionnaire including the System Usability Scale and the Net Promoter Score (NPS) after using the cabin. ResultsThe data analysis of the first phase showed high acceptance of the telehealth cabin, which supported the progression to the second phase. …”
Get full text

Rationalisation of laboratory tests ordering and consumption at Armed Forces Hospital, Jazan by Manal Ahmed Aldiba, Essa Mohammad Jamali, Ahmed Dighriri, Ahmed Mohammad Abdulhaq, Ali Mohammad Otaif, Bader Yahya Safhi, Ali Al-Fageeh, Ahmed Al-Sharif, Yara Rabia Ali

“…In order to determine the possible causes of the problem, fishbone diagram was used to structure a brainstorming session. Pareto analysis was used to prioritise the causes so that the emphasis can be laid on most significant one. …”
Get full text

Student-Doctor Method for Clinical Training Among Phase III Part II MBBS Students by Moneesha Srinivasan, Manohari Ramachandran, Amudhaganesh Selvaraj, Jeevithan Shanmugam

“…After a one-week clerkship experience, students presented their cases, and a post-test along with structured feedback questionnaires was administered. Quantitative data were analyzed using SPSS version 27, employing paired t-tests for pre- and post-test comparisons, while qualitative feedback was subjected to thematic content analysis. …”
Get full text

Identifying factors related to sertraline concentrations in child/adolescent and adult patients: insights from a therapeutic drug monitoring service by Ruoming Li, Bin Bi, Zhe Dong, Sai Chen, Yuan Yun, Xiuhuan Wang, Hasenqimuge, Song Chen, Yunlong Tan

“…Methods We conducted a retrospective analysis of TDM data from 1076 patients (474 children/adolescents and 602 adults) collected between 2018 and 2024. …”
Get full text

Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility by Vincenzo Condello, William R Doerfler, Alyaksandr V Nikitski, Daniel M Spagnolo, Ian J Fornal, Gavin M Schmidt, Abigail I Wald, Marina N Nikiforova, Yuri E Nikiforov

“…Results: On RNA-seq analysis, invasive RAS-mutant tumors showed different gene expression profiles compared to non-invasive tumors. …”
Get full text

Beyond traditional training: a comprehensive CIPP evaluation of medical internships: assessing program design, implementation, and clinical competency outcomes by Nooshin Yoshany, Seyed Saeed Mazloomy Mahmoodabad, Leila Moradi, Manoj Sharma

“…Data were collected using a questionnaire based on the CIPP model that developed by researchers. …”
Get full text

Study on Discrete Null-Field Equation Methods for Bounded Simply Connected Domains: Better Locations of Source Nodes by Li-Ping Zhang, Zi-Cai Li, Hung-Tsai Huang, Ming-Gong Lee, Alexander L. Kazakov

Get full text