Pharmacokinetics‐Based Design of Subcutaneous Controlled Release Systems for Biologics by Abigail K. Grosskopf, Antonio A. Ginart, Phillip Spinosa, Vittal Shivva

“…Despite their substantial potential, significant hurdles remain in appropriately applying and integrating these technologies with the ongoing development of complex biologic‐based therapies. We evaluate the potential impact of subcutaneously delivered controlled release systems on the downstream pharmacokinetics (PK) of several FDA‐approved biologics by employing rigorous mathematical analysis and predictive PK simulations. …”
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ATP6AP1 drives pyroptosis-mediated immune evasion in hepatocellular carcinoma: a machine learning-guided therapeutic target by Lei Tang, Xiyue Wang, Zhengzheng Xia, Jiayu Yan, Shanshan Lin

“…Methods We integrated large-scale datasets from TCGA and GEO databases to identify core modules by weighted gene co-expression network analysis (WGCNA), while mutation profiling and survival analysis verified clinical relevance. …”
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A METHODOLOGICAL APPROACH TO DESIGNING EXPERIMENTS WHEN DEALING WITH IDENTIFICATION TESTS FOR MEDICINAL PRODUCT COMPONENTS (AS ILLUSTRATED BY ASCORBIC ACID) by Yu. B. Purim, M. L. Kruglyakova, L. N. Bulanova, M. V. Agapkina, L. N. Stronova, T. N. Bokovikova, E. P. Gernikova

“…Material and methods: the study focused on a multi-component medicinal product — lyophilisate for solution for intravenous and intramuscular  injections containing an antiinflammatory active substance and ascorbic acid as a stabilizing agent (antioxidant). The analysis of literature sources helped to determine qualitative tests that were assessed for potential use for identification testing of ascorbic acid as a component of the analysed medicinal product. …”
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Insights into the Mechanism Underpinning Composite Molecular Docking During the Self-Assembly of Fucoidan Biopolymers with Peptide Nanofibrils by Rui Li, Min-Rui Tai, Xian-Ni Su, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong, David. R. Nisbet, Colin J. Barrow, Richard J. Williams

“…Nevertheless, the precise interactions, and the electrochemical and thermodynamic stability of these composite materials have not been determined. …”
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Temporal dynamics of soil microbial symbioses in the root zone of wolfberry: deciphering the effects of biotic and abiotic factors on bacterial and fungal ecological networks by Mengyuan He, Mengyuan He, Mengyuan He, Qianqian Wang, Yiming Wang, Junhua Zhang

“…The partial least squares path modeling (PLS-PM) analysis emphasized that stand age can indirectly regulate the diversity and network complexity of both bacterial and fungal communities by influencing soil physicochemical properties. …”
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International Migration and Its Consequences Affecting Population Management in Isfahan Province: A Grounded Theory Study by Mohammad Hosain Ghanbari Jahromi, Javad Esteki, Hamid Nazari

“…The findings revealed that foreign migration to Isfahan was driven and exacerbated by a range of complex factors, which we categorized into causal, background, and intervention conditions. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Moreover, the molecular simulation analysis confirmed the binding stability, structural compactness, and residue flexibility properties of these compounds. …”
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Cyclodextrin-Based Drug Delivery Systems for Depression: Improving Antidepressant Bioavailability and Targeted Central Nervous System Delivery by Renata Maria Văruț, Alin Iulian Silviu Popescu, Simina Gaman, Carmen Elena Niculescu, Adrian Ștefan Niculescu, Dalia Dop, Mioara Desdemona Stepan, Nina Ionovici, Cristina Elena Singer, Cristina Popescu

“…This review synthesizes current evidence demonstrating that complexing various classes of antidepressants—such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and atypical antidepressants—with β-CD or its derivatives significantly enhances drug solubility and stability. …”
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Polystyrene microspheres could inhibit the ferroptosis of prostate cancer cells via USP39/IGF2BP3/MAPK4 axis by Shengming Lu, Ruipeng Wu, Weijian Li, Zhenyu Fu, Xuefei Ding, Yang Luan, Huang Tianbao, Yuhua Huang

“…It was found that USP39 interacts with IGF2BP3, which, in turn, stabilizes MAPK4, a key regulator of ferroptosis. Conclusions These findings illuminate the complex relationship between environmental pollutants such as PS and cancer progression, offering new avenues for research and potential therapeutic interventions in prostate cancer.…”
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Design, Mathematical Modeling, and Control of an Underactuated 3-DOF Experimental Helicopter by Osamah Talal Makki, Seyyed Sajjad Moosapour, Saleh Mobayen, Jafar Heyrani Nobari

“…The model takes into account the complex dynamics and interactions between the system components, providing a more comprehensive representation of the real system compared to previous models. …”
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Presenting the model of factors affecting the resilience of entrepreneurial behavior in Technical and Vocational University of Alborz province by Ali Abdi Jamayran, Manouchehr Niknam, Hasan Rangriz

“…A semi-structured interview was used to collect information and the interviews continued until reaching theoretical saturation. For analysis, open and axial and selective coding through MAXQDA software was used. …”
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A Study on the Dynamic Evolution and Prevention of Technological Innovation Risks in Major Railway Projects by Feng Guo, Qixuan Liu, Lemin Li, Yixue Zuo, Yifang Pan, Wanping Pan

“…This paper identifies the risk factors of technological innovation in major railway projects, establishes a system dynamics model of technological innovation risk evolution, and carries out simulation analysis by taking the C railway project as an example, to understand the risk evolution process, clarify the key tasks of risk prevention, and finally draw the following research conclusions: (1) Technological innovation risk is categorized into innovation management risk, technology R&D risk, and technology application risk, of which innovation management risk has a greater impact on technological innovation risk. (2) During the construction process, the risk of technological innovation shows a general trend of increasing and then stabilizing, with the technology R&D stage being the centralized emergence stage of technological innovation risk. (3) Changes in the values of risk factors will have different degrees of impact on technological innovation risk, with changes in planning and implementation having the greatest impact on the technological innovation risk system, followed by the feasibility of results, and changes in the value of technological difficulties risk having a lesser impact on the system. …”
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Combustion Characteristics of Liquid Ammonia Direct Injection Under High-Pressure Conditions Using DNS by Ziwei Huang, Haiou Wang, Qian Meng, Kun Luo, Jianren Fan

“…The distribution of scalar dissipation rate at various locations is nearly log-normal. The budget analysis of species transport equations shows that the reaction term is much larger than the diffusion term, suggesting that auto-ignition plays a predominant role in turbulent ammonia spray flame stabilization. …”
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Deep quantification of substrate turnover defines protease subsite cooperativity by Rajani Kanth Gudipati, Dimos Gaidatzis, Jan Seebacher, Sandra Muehlhaeusser, Georg Kempf, Simone Cavadini, Daniel Hess, Charlotte Soneson, Helge Großhans

“…Here, we develop qPISA (quantitative Protease specificity Inference from Substrate Analysis) to study Dipeptidyl Peptidase Four (DPP4), a key regulator of blood glucose levels. …”
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Characterization and Antimicrobial Activity of Silverrods Nano: Synthesized in Green Ocimum sanctum Leaf Extract by Malik Ahmad Al-Natour, Mohammad Faiyaz Anwar, Shah Alam Khan, Mohammad Changez

“…It contains an array of complex and diverse biologically active phytochemical constituents that can act as a reducing and stabilizing agent for synthesizing metal nanoparticles (NPs). …”
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Lactobacilli as additional cultures in cheese making by N. P. Sorokina, I. V. Kucherenko, A. L. Bruckaya

“…The authors demonstrate the complex autochthonous microbiota of cheeses and a possibility of stabilization of fermentation upon cheese making from raw milk and improvement of their quality without losing individuality due to the introduction of selected autochthonous additional cultures. …”
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Memory-corrected quantum repeaters with adaptive syndrome identification by Alena Romanova, Peter van Loock

“…We address the challenge of incorporating encoded quantum memories into an exact secret key rate analysis for small and intermediate-scale quantum repeaters. …”
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Spectroscopic and Molecular Docking Studies on the Influence of Inulin on the Interaction of Sophoricoside with Whey Protein Concentrate by Anna Wang, Mengyang Xie, Ligen Wu

“…Three-dimensional fluorescence spectral analysis showed a reduction in fluorescence intensity and a red shift in the presence of both Sop and inulin. …”
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Servant leadership in crisis management: leadership response in the management of Covid-19 pandemic in Ghana by Kwame Asamoah, Emmanuel Kems Bigodza

“…It also extends our understanding of how servant leadership can be operationalized in response to complex and systemic challenges such as crisis.…”
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Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201. by Iva Trenevska, Amanda P Anderson, Carol Bentley, Tasneem Hassanali, Sarah Wiblin, Shaun Maguire, Francesco Pezzella, Alison H Banham, Demin Li

“…T-cell receptor mimic (TCRm) antibodies have expanded the repertoire of antigens targetable by monoclonal antibodies, to include peptides derived from intracellular proteins that are presented by major histocompatibility complex class I (MHC-I) molecules on the cell surface. …”
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