Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol by Wei Li, Hui Shen, Tian Zhang, Li Chen, Manyu Zhang, Lan Hu, Liu Yang, Yanan Peng, Shijun Gao, Zhibin Chen, Tan Wang, Zhenqiang Zhao

“…Our primary outcome will be the functional disability component related to tremors, as measured by the Fahn-Tolosa-Marin Tremor Rating Scale subscales B and C. …”
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Green synthesis and characterization of silver-doped ZnO nanoparticles using tobacco leaf extract: A novel hydrothermal approach for antibacterial and antifungal applications by Jebel Haji Mahamud, Abebe Belay Gemta, Alemu Kebede Hordofa, Getachew Abebe Argaw, Umer Sherefedin, Muktar Ahmed, Tesfaye Feyisa Hurrisa, Gurumurthi T.

“…Characterization techniques included FTIR, XRD, SEM, UV‒Vis, and PL spectroscopy, along with BET surface area analysis. FTIR confirmed functional groups, while x-ray diffraction (XRD) validated the hexagonal wurtzite ZnO structure. …”
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Effect of continuous fiber reinforcement on mechanical and tribological characteristics of cellulose and human hair fiber polymer composites by K․S․Ashraff Ali, Samraj Ravi, Vinayagam Mohanavel, Manikandan Ayyar, Selvakumar Kathiresan, Sathish Kannan, Arunkumar Munimathan, Manzoore Elahi M. Soudagar, Seeniappan Kaliappan

“…Frictional materials present a new challenge in today's automotive and manufacturing sectors as they improve the capacity for self-lubrication while meeting functional criteria like reduced noise, friction, and heat resistance. …”
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Immunoregulatory Effects of <i>Codonopsis pilosula</i> Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice by Yan Long, Hongfei Ji, Jiajing Yang, Haiyu Ji, Keyao Dai, Wenjie Ding, Guoqiang Zheng, Juan Yu

“…These findings could provide theoretical support and data foundation for further development of CPP-SeNPs as functional food and drug adjuvants.…”
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Prevalence of insomnia, fatigue and symptoms of mental health problems among emergency medical service nurses: a cross-sectional study by Marieke M.E. Oosterhuis-Nienhaus, Lilian C.M. Vloet, Sarah I. Detaille, Hester Vermeulen, Jan Hoefnagel, Mischa Knol, Ellen Schepens, Mark van den Boogaard, Sivera A. A. Berben, Remco H. A. Ebben

“…Abstract Background Emergency medical service nurses worldwide face continuous high-stress situations caused by critical incidents that can overwhelm them emotionally and affect their daily functioning and sustainable employability. Repeated exposure to these incidents negatively impacts their mental health. …”
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Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma by Yuchen Zhang, Junnian Zheng, Li Sun, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Renjin Chen, Dafei Chai, Jiawei Wang, Zichun Zhang, Xiaohui Xie

“…Expression of Siglec-E on the immune cells has been shown to promote tumor regression. This study aimed to develop an adenovirus (Ad) vaccine targeting Siglec-E and carbonic anhydrase IX (CAIX) (Ad-Siglec-E/CAIX) and to evaluate its potential antitumor effects in several preclinical renal cancer models.Methods Ad vaccines encoding Siglec-E or CAIX were developed and evaluated for their therapeutic potential in mouse subcutaneous, lung metastatic, and orthotopic tumor models. …”
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Older surgical patients’ preferences for follow-up care after hospital discharge: A multi-method qualitative study into their underlying needs by Aafke J de Groot, Marike E de Boer, Elizabeth M Wattel, Cees MPM Hertogh, Marja FIA Depla

“…Background: Almost 30 % of older patients suffer from functional decline during hospital stay which often makes follow-up care decisions necessary. …”
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Identification of key modules and hub genes for sepsis-induced myopathy using weighted gene co-expression network analysis by Siming Lin, Siming Lin, Siming Lin, Kexin Cai, Kexin Cai, Kexin Cai, Ai Chen, Weibin Wu, Guili Lian, Shaodan Feng, Shaodan Feng, Zhihong Lin, Zhihong Lin, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie

“…Additionally, we performed functional enrichment analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network approaches.ResultsOur findings revealed that the identified gene clusters predominantly pertained to immune response, inflammation, and apoptosis pathways. …”
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Are cocoa plantations suitable habitats? Network between parasites (Diptera: Hippoboscidea) and hosts (Mammalia: Chiroptera) in cocoa-dominated landscapes of the Brazilian Amazon by Samantha Valente Dias, Rafaela Jemely Rodrigues Alexandre, Letícia Lima Correia, Ludmilla M. S. Aguiar, Gustavo Graciolli, Daniel Maximo Correa Alcantara, Thiago Bernardi Vieira, Thiago Bernardi Vieira

“…This study aims to assess bat and batfly species to understand how land-use changes affect antagonistic interaction networks between ectoparasitic flies and Phyllostomidae bats. …”
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Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM by Xiaofeng Zhou, Zhifang Liu, Weixiong Zhang, Lin Dai, Tao Chen, Zexiong Lin, Hong Pan, Qi Qi, Henry Wei

“…Single-domain antibodies (sdAbs), in contrast, offer advantages such as efficient tumor penetration and reduced immunogenicity. This study aims to screen and explore novel sdAbs targeting EpCAM for cancer therapy.MethodsA critical EGF-like repeat epitope on the EpCAM extracellular domain was selected for screening a human sdAb library via phage display. …”
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Procedural simplification in mitral valve transcatheter edge-to-edge repair: full echocardiographic guidance and outcomes by Jianrui Ma, Peijian Wei, Fengwen Zhang, Junke Chang, Manchen Gao, Chuangshi Wang, Xiaofang Yan, Cheng Wang, Shouzheng Wang, Yongquan Xie, Fang Fang, Xiangbin Pan

“…Significant MR reduction and improvements in New York Heart Association functional class were observed in both groups (p < 0.05). …”
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Comprehensive analysis of prognosis and drug sensitivity of programmed cell death pattern-related genes in gastric cancer patients by Huiheng Qu, Peng Zhou, Zhihui Yang, Hao Wang, Kaiyuan Deng, Nan Wang, Yuyang Li, Yupeng Zhao, Yigang Chen, Qian Yang, Jiazeng Xia

“…Programmed cell death (PCD) plays a crucial role in the development and metastasis of malignant tumors. This study aimed to investigate the underlying PCD-related molecular mechanisms and develop predictive models for GC. …”
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Lymphocyte activation gene 3 served as a potential prognostic and immunological biomarker across various cancer types: a clinical and pan‐cancer analysis by Yifan Liu, Yuntao Yao, Xinyue Yang, Maodong Wei, Bingnan Lu, Keqing Dong, Donghao Lyu, Yuanan Li, Wenbin Guan, Runzhi Huang, Guofeng Xu, Xiuwu Pan

“…However, its impact on tumours has yet to be comprehensively elucidated on a pan‐cancer scale. Thus, we aim to reveal its role at the pan‐cancer level. …”
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Cutaneous dysbiosis in girls with vulvar lichen sclerosus by Liying Sun, Huihui Gao, Hongyu Chen, Chenfei Ren, Junwen Zhang, Qiuxiang Shen, Li Zhu, Dandan Chen, Lingling Jin, Chaoqun Wang, Fengxia Li, Lan Yu

“…Microbial diversity was assessed using α diversity, β diversity, and LEfSe, and functional microbial pathways were predicted. No differences were observed in α diversity among groups. …”
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MEK inhibitor PD0325901 upregulates CD34 expression in endothelial cells via inhibition of ERK phosphorylation by Chihiro Hosoda, Seiji Mitani, Asuka Sakata, Shogo Kasuda, Yu Onodera, Yoko Takabayashi, Midori Shima, Kohei Tatsumi

“…Therefore, we aimed to generate CD34-positive cells by the reprogramming of endothelial cells (ECs). …”
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Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma by Youyi Wu, Chen Lin, Chen Lin, Yuchen Qian, Xiaowei Huang, Yajing Xu, Jiayi Li, Youdi He, Congying Xie, Huafang Su

“…This model was verified using the IMvigor210 dataset, and we functionally validated the immune risk score model in vitro.ResultsThe results revealed significant correlations between CD8+ T cell-related genes and immune-related pathways. …”
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IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…In vitro and in vivo functional studies were conducted to evaluate the role and mechanisms of IFITM3 in modulating tumor sensitivity to PD-1 inhibitors. …”
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Diffuse gliomas: insights into clinical and histopathological features and survival rates from two centers in a middle-income country by Edgar G. Ordóñez-Rubiano, Edgar G. Ordóñez-Rubiano, Edgar G. Ordóñez-Rubiano, Cristian Siabato, Nicolás Rincón-Arias, Nicolás Rincón-Arias, Paula A. Pulido, Paula A. Pulido, Hebert D. Pimienta-Redondo, Hebert D. Pimienta-Redondo, Sebastián Espinosa-Gaona, Sebastián Espinosa-Gaona, Santiago Useche-Diosa, Santiago Useche-Diosa, María Andrea Moreno, María Andrea Moreno, Hernando A. Cifuentes-Lobelo, Oscar F. Zorro-Guio, Javier G. Patiño-Gómez, Javier G. Patiño-Gómez, Alba Lucía Cómbita, César Payán-Gómez, Luz D. Gutierrez-Castañeda, Luz D. Gutierrez-Castañeda, Alexandra Ramos-Márquez, Alexandra Ramos-Márquez, Diego F. Gómez, Oscar Mendoza, Matias Baldoncini, Matias Baldoncini, Rafael Parra-Medina, Rafael Parra-Medina

“…IntroductionGliomas are believed to arise from neuroglial stem cells and are histologically classified based on morphological similarities to normal neuroglial cells. This study aims to describe the clinical, histopathological, and demographic features of glioma patients treated in two reference centers in Colombia.MethodsThis descriptive cross-sectional study included all patients with a histologically confirmed glioma treated at two institutions in Bogotá, Colombia, between January 2015 and December 2023. 272 patients with diffuse gliomas were included, and data were collected on sociodemographic characteristics, clinical presentation, histopathologic diagnosis, immunohistochemical markers, extent of resection, functionality, complications, and survival.ResultsAmongst all cases, 36.00% were glioblastomas, 14.70% oligodendrogliomas, and 12.10% astrocytomas. 49.10% of patients were females, average age was 48.8 ± 21.0 years. …”
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Primary Prevention Strategy for Non-Communicable Diseases (NCDs) and Their Risk Factors: The Role of Intestinal Microbiota by Itzel Ivonn López-Tenorio, Óscar Rodrigo Aguilar-Villegas, Yoshua Espinoza-Palacios, Lorena Segura-Real, Berenice Peña-Aparicio, Amedeo Amedei, María Magdalena Aguirre-García

“…The onset of these diseases has been associated with an imbalance in certain microbial niches, such as the gut, which hosts billions of microorganisms performing multiple metabolic functions, such as the production of metabolites like bile acids (BAs), short-chain fatty acids (SCFAs), and trimethylamine N-oxide (TMAO). …”
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PYGO1 drives gastric cancer progression via the ITGB1/CD47 axis and is therapeutically targeted by pentagalloylglucose by Yanjuan Jia, Yaling Li, Yan Li, Yonghong Li, Tao Qu, Zhuomin Fu, Yuanyuan Ma, Zhenhao Li, Wanxia Wang, Miao Yu, Xiaojie Jin, Xiaoling Gao, Yongqi Liu

“…This study aims to elucidate the role of PYGO1 in GC and uncover its regulatory mechanisms. …”
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