Loss of RhoA in microglia disables glycolytic adaptation and impairs spinal cord injury recovery through Arhgap25/HIF-1α pathway by Jiale Cai, Xinya Zheng, Xiongbo Luo, Wenli Cui, Xinrui Ma, Shuyi Xu, Lanya Fu, Jiaqi Zhang, Yizhou Xu, Yunlun Li, Ye He, Xianghai Wang, Jiasong Guo

“…Although RhoA inhibition has been traditionally viewed as beneficial for SCI repair, recent clinical trials of RhoA inhibitors in SCI have failed to show significant therapeutic efficacy, suggesting functional heterogeneity across different cell types. …”
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Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation by Fang Li, Zenan Sun, Ahmed abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, DeLisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

“…Meanwhile, the model was holistically optimized using multiple loss functions, to ensure the predicted results closely align with the ground-truth values from various perspectives. …”
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Comparative genomic analysis of trypanosomatid protists illuminates an extensive change in the nuclear genetic code by Kristína Záhonová, Zoltán Füssy, Amanda T. S. Albanaz, Anzhelika Butenko, Ambar Kachale, Natalya Kraeva, Arnau Galan, Alexandra Zakharova, Bojana Stojanova, Jan Votýpka, Alexei Y. Kostygov, Viktoria V. Spodareva, Marina N. Malysheva, Alexander O. Frolov, Igor B. Rogozin, Zdeněk Paris, Leoš Shivaya Valášek, Vyacheslav Yurchenko, Julius Lukeš

“…We conducted a comparative analysis of four Blastocrithidia species, all with the same non-canonical genetic code, and their close relatives of the genus Obscuromonas, which retain the canonical code. This across-genome comparison allowed the identification of key traits associated with genetic code reassignment in Blastocrithidia. …”
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White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder by Xixi Yang, Martina D. Liechti, Baris Kanber, Carole H. Sudre, Gloria Castellazzi, Jiaying Zhang, Marios C. Yiannakas, Gwen Gonzales, Ferran Prados, Ahmed T. Toosy, Claudia A. M. Gandini Wheeler-Kingshott, Jalesh N. Panicker

“…Objectives: We aim to evaluate (i) microstructural WM differences across MS patients (pwMS) with OAB symptoms, patients without LUT symptoms, and healthy subjects using diffusion tensor imaging (DTI), and (ii) associations between clinical OAB symptom scores and DTI indices. …”
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Mandibular reconstruction outcomes for in-house patient-specific solutions by Matthew D. Marquardt, Erin Cowen, Rachel Fenberg, Natalia von Windheim, Margaret Lashutka, Abigail E. Reid, Amit Agarwal, Enver K. Ozer, Ricardo L. Carrau, James W. Rocco, Catherine T. Haring, Stephen Y. Kang, Nolan B. Seim, Matthew O. Old, Kyle K. VanKoevering

“…The advent of computer-aided design and manufacturing (CAD/CAM) has enhanced aesthetic and functional outcomes in mandibular reconstruction by enabling patient-specific solutions like 3D-printed anatomic models. …”
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Impact of Climate and Soil on Plant Dynamics and Ecosystem Stability in Argan Orchards by Maryem Telmoudi, Chaima Afi, Naima Chabbi, Said Labbassi, Assma Oumasst, Mohamed Ouknin, Rachid Bouharroud, Abdelaziz Mimouni, Mimoun El Kaoua, Driss Hsissou, Abdelghani Tahiri, Naima Ait Aabd

“…This study explores the indirect effects of natural disturbances on community metrics in argan orchards, assessing plant diversity, biomass, and density across different orchard types. It highlights the influence of climate, soil properties, and biotic interactions on plant community dynamics. …”
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Molecular Clouds in the Outer Milky Way Disk: Sample, Integrated Properties, and Radial Trends with Galactocentric Radius by Yan Sun, Ji Yang, Qing-Zeng Yan, Shaobo Zhang, Yang Su, Xuepeng Chen, Xin Zhou, Yuehui Ma, Lixia Yuan

“…We systematically analyze both the integrated properties and scaling relationships of these molecular clouds across different Galactocentric radii (8 < R _GC < 26 kpc). …”
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Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy by Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Joanne Weidhaas, Mark Scholz, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Donatello Telesca

“…We tested the hypothesis that germline microRNA pathway functional variants, known to predict altered systemic stress responses to cancer therapies, would predict irAEs in patients across cancer types.Methods MicroRNA pathway variants were evaluated for an association with grade 2 or higher toxicity using four classifiers on 62 patients with melanoma, and then the panel’s performance was validated on 99 patients with other cancer types. …”
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Characterization of full-length long noncoding RNAs and identification of virus-responsive lncRNAs in Sogatella furcifera by Yawen Ban, Yawen Ban, Ting Cui, Ting Cui, Lifei Zhao, Lifei Zhao, Xue Li, Xue Li, Qing Bai, Qing Bai, Qingfa Wu, Qingfa Wu

“…Altogether, this study provides the first full-length lncRNA reference for S. furcifera and reveals the dynamic regulation of lncRNAs across development and in response to viral infection. …”
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Whole genome sequencing reveals virulence–mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria by Nubwa Medugu, Nubwa Medugu, Mabel Kamweli Aworh, Mabel Kamweli Aworh, Kenneth Iregbu, Philip Nwajiobi-Princewill, Dawn M. Hull, Lyndy Harden, Pallavi Singh, Stephen Obaro, Abiodun Egwuenu, Faith Adeboye, Ruth Egah, Leonard Uzairue, Yahaya Mohammed, Nwafia Ifeyinwa, Siddhartha Thakur

“…BackgroundMultidrug-resistant Escherichia coli poses a critical public health threat in Nigeria, where limited genomic surveillance hinders the understanding of virulence-resistance interplay.MethodsThis cross-sectional study employed whole-genome sequencing to characterize 107 MDR-E isolates from a Nigerian tertiary hospital (2019–2020), analyzing virulence genes, mobile genetic elements (MGEs), phylogroups, sequence types (STs), pathotypes, and antimicrobial resistance (AMR).ResultsWe identified 2,021 virulence genes across nine functional categories, dominated by immune evasion (terC, 96.3%), adherence (fimH, 86%), and iron acquisition (fyuA, 63.6%). …”
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Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…ABSTRACT As a universal language across the bacterial kingdom, the quorum sensing signal autoinducer-2 (AI-2) can coordinate many bacterial group behaviors. …”
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Geographic variation in secondary metabolites contents and their relationship with soil mineral elements in Pleuropterus multiflorum Thunb. from different regions by Yaling Yang, Siman Wang, Ruibin Bai, Feng Xiong, Yan Jin, Hanwei Liu, Ziyi Wang, Chengyuan Yang, Yi Yu, Apu Chowdhury, Chuanzhi Kang, Jian Yang, Lanping Guo

“…This study aimed to investigate the variations in the distribution of active components in HSW across diverse planting regions and their relationship with soil mineral elements. …”
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Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…Despite its significance, the specific functions and mechanisms of PANoptosis within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) remain unclear. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…This would allow for a meta-synthesis of the results across trials. SUSTAIN does not include testing an intervention for carers. …”
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Dynamic behavior of the nucleus pulposus within the intervertebral disc loading: a systematic review and meta-analysis exploring the concept of dynamic disc model by Jean-Philippe Deneuville, Jean-Philippe Deneuville, Jean-Philippe Deneuville, Maxime Billot, Alexandra Cervantes, Sylvain Peterlongo, Martin Meyer, Mezika Kolder, Marie Escande, Mathilde Bourgeois, Adrien Pallot, Adrien Pallot, Romain David, Romain David, Romain David, Manuel Roulaud, Amine Ounajim, Mark Laslett, Mathieu Sarracanie, Najat Salameh, Arnaud Germaneau, Philippe Rigoard, Philippe Rigoard, Philippe Rigoard

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Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures by Sylvain Rheims, Fatima Chorfa, Véronique Michel, Edouard Hirsch, Louis Maillard, Luc Valton, Fabrice Bartolomei, Philippe Derambure, Vincent Navarro, Julien Biberon, Arielle Crespel, Anca Nica, Martine Lemesle Martin, Laure Mazzola, Jerome Petit, Vincent Rossero, Sébastien Boulogne, Mathilde Leclercq, Laurent Bezin, Catherine Mercier, Pascal Roy, Philippe Ryvlin, the ENALEPSY Study Group

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A Sociological Study of Monetary Attitudes among Citizens of Tehran by Nahid Abdoli, Asadollah Babaiefard

“…Currently, the cultural and social functions of money—understood as a "fait social total"—are undergoing significant changes. …”
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Integrated proteomics and transcriptomics analysis reveals key regulatory genes between ER-positive/PR-positive and ER-positive/PR-negative breast cancer by Zhengjia Lu, Jiao Yang, Yang Feng, Jia Ming

“…Additionally, there were differences in functional pathway enrichment analysis (galactose_metabolism, glycolysis_gluconeogenesis, jak_stat_signaling_pathway, pentose_phosphate_pathway, et al.) and immune cell infiltration (CD8 T cell, Macrophages M1, et al.) between the high-risk and low-risk groups. …”
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Patient-Reported Outcome Measures in Patients with Rheumatoid Arthritis, Psoriasis, or Psoriatic Arthritis Treated with GP2015, an Etanercept Biosimilar: Results from Two Phase III... by Diamant Thaçi, Sascha Gerdes, Hendrik Schulze-Koops, Yannick Allanore, Arthur Kavanaugh, Charlotte Both, Sreekanth Gattu, Sohaib Hachaichi, Marco Matucci-Cerinic

“…Conclusion Treatment with GP2015 and ref-ETN resulted in similar improvements in PROs and quality-of-life scores across the three diseases, namely RA, PsA, and PsO. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…This study presents the first evidence that altered liver functions are associated with pathological behaviors arising from genetic SERT deficiency.…”
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