Clostridium butyricum: a promising approach to enhancing intestinal health in poultry by Xiaopeng Tang, Yan Zeng, Meijun Li

“…Clostridium butyricum (C. butyricum) is a probiotic bacterium that has been shown to be a promising candidate for improving intestinal function and subsequently optimizing poultry growth. …”
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Entry Guidance for Hypersonic Glide Vehicles via Two-Phase hp-Adaptive Sequential Convex Programming by Xu Liu, Xiang Li, Houjun Zhang, Hao Huang, Yonghui Wu

“…This paper addresses the real-time trajectory generation problem for hypersonic glide vehicles (HGVs) during atmospheric entry, subject to complex constraints including aerothermal limits, actuator bounds, and no-fly zones (NFZs). …”
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Coupled motions direct electrons along human microsomal P450 Chains. by Christopher R Pudney, Basile Khara, Linus O Johannissen, Nigel S Scrutton

“…Motions critical to the broader biological functions of CPR are tightly coupled to enzyme chemistry in the human NADPH-CPR-CYP redox chain. …”
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The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling by Kara A Nelson, Kari F Lenhart, Lauren Anllo, Stephen DiNardo

“…Consistency of niche position suggests that placement is important for niche function. However, the complexity of most niches has precluded a thorough understanding of how their proper placement is established. …”
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“Loss of polarity of basal cells” – The term revisited in the light of genomics by Debasish Pramanick, Richa Singh, Bidyut Roy, Anjana Mazumdar, Sandip Ghose

“…The epithelial cells exhibit apicobasal polarity which is maintained by Crumbs complex located at apical region of tight junction, ‘PAR’ complex at sub-apical region of tight junction and Scribble complex at adherens junction. …”
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Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis by Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz

“…The development of septic cardiomyopathy is due to complex interactions of damage-associated molecular patters, cytokines, and complement activation products. …”
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Thermo-Hydro-Mechanical Coupling Numerical Simulation on Mechanical Heterogeneity of Coal Rock by Shuiqing Hu, Daobing Wang, Yipeng Li, Xiongfei Liu, Fujian Zhou, Meng Wang, Chunming He, Bo Yu

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The Intestinal Thread of Fate: How the Microbiota Shapes the Story of Liver Disease by Carlo Acierno, Riccardo Nevola, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…The gut–liver axis plays a critical role, with factors like altered bile acid metabolism and toxic metabolites such as hydrogen sulfide worsening intestinal barrier function and fueling chronic inflammation. This review aims to explore the complex role of the gut–liver axis in MASLD progression, highlighting the mechanisms of intestinal barrier dysfunction, dysbiosis, and microbial contributions to liver injury. …”
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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation by Dingwu Qu, Zhennan Gu, Saisai Feng, Leilei Yu, Fengwei Tian, Hao Zhang, Wei Chen, Qixiao Zhai

“…The probiotic strains differed in regulating the intestinal microbiota, cytokines (IL-10, IL-1β and interferon (IFN)-γ), and tight junction function (Zonulin-1 and Occludin). …”
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Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium. by Talita B Gagliardi, Monty E Goldstein, Daniel Song, Kelsey M Gray, Jae W Jung, Maxinne A Ignacio, Kimberly M Stroka, Gregg A Duncan, Margaret A Scull

“…Finally, RV-C15 infection resulted in a temporary loss in epithelial barrier integrity and the translocation of tight junction proteins while a reduction in mucociliary clearance indicated cytopathic effects on epithelial function. …”
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Well Performance from Numerical Methods to Machine Learning Approach: Applications in Multiple Fractured Shale Reservoirs by Kailei Liu, Boyue Xu, Changjea Kim, Jing Fu

“…Horizontal well fracturing technology is widely used in unconventional reservoirs such as tight or shale oil and gas reservoirs. Meanwhile, the potential of enhanced oil recovery (EOR) methods including huff-n-puff miscible gas injection are used to further increase oil recovery in unconventional reservoirs. …”
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A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia by Geli Li, Yuchen Ma, Sujie Zhang, Wen Lin, Xinyi Yao, Yating Zhou, Yanyong Zhao, Qi Rao, Yuchen Qu, Yuan Gao, Lianmin Chen, Yu Zhang, Feng Han, Meiling Sun, Chen Zhao

“…To better understand the complex multifaceted roles of BMECs in the regulation of ischemic stroke pathophysiology and facilitate BMEC-based drug target discovery, we utilized a transcriptomics-informed systems biology modeling approach and constructed a mechanism-based computational multipathway model to systematically investigate BMEC function and its modulatory potential. …”
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The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae. by Scott G Shanks, Lindsay N Carpp, Marion S Struthers, Rebecca K McCann, Nia J Bryant

“…Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. …”
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Thick-panel origami structures forming seamless surfaces by Rui Peng, Gregory S. Chirikjian

“…Abstract Thick-panel origami structures are able to deploy into expansive configurations, making them suitable for industrial applications such as deployable stadium domes, water-tight roof tiling, sun shields, furniture, antennas, solar arrays, space telescopes, etc. …”
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Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis by Zhiqi Xiong, Xiaolin Yang, Shule Wang, Caitlan J. Smart, Hazel M. Sisson, Zhenli Lin, Tianyu Hu, Yuting Ran, Chuyao Xu, Xiuna Yang, Yao Zhao, William J. Jowsey, Gregory M. Cook, Matthew B. McNeil, Luke W. Guddat, Zihe Rao, Bing Zhang

“…The stalk secures the tight association of the three MmpL5 subunits and exhibits intrinsic structural flexibility. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by social communication deficits and restricted, repetitive behaviors. …”
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Optimal estimates of trace distance between bosonic Gaussian states and applications to learning by Lennart Bittel, Francesco Anna Mele, Antonio Anna Mele, Salvatore Tirone, Ludovico Lami

“…In this work, we fully resolve this question by demonstrating that if the first and second moments are known up to an error $\varepsilon$, the trace distance error on the state also scales as $\varepsilon$, and this functional dependence is optimal. To prove this, we establish tight bounds on the trace distance between two Gaussian states in terms of the norm distance of their first and second moments. …”
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How (Ultra‐)Rare Gene Variants Improve Our Understanding of More Common Autoimmune and Inflammatory Diseases by Alexandre Belot, Maud Tusseau, Jade Cognard, Sophie Georgin‐Lavialle, Guilaine Boursier, Christian M. Hedrich

“…Additional monogenic diseases such as ELF4, WDR1 mutations and trisomy 8 further illustrate the genetic complexity of this condition. Observations from genetic studies in SLE and Behçet syndrome highlight the complexity of systemic inflammatory diseases in which distinct molecular defects caused by single‐gene mutations can promote lupus or Behçet syndromes, often unrecognizable from their genetically complex “classical” forms. …”
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PREDICTION ENDOMETRIAL CANCER IN WOMEN WITH ENDOMETRIAL HYPERPLASTIC PROCESSES IN PREMENOPAUSAL by A. L. Unanyan, I. S. Sidorova, E. A. Kogan, D. V. Baburin

“…We have identified risk factors and determined their significance and relative risk in endometrial oncotransformation based on mathematical analysis of clinical and anamnestic data and molecular-biological indicators. The structural, functional and molecular mechanisms of hyperplastic processes of endometrium in premenopausal women were investigated based on a complex immunohistochemical studies. …”
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Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. by André Schultz, Amina A Qutub

“…Human metabolism involves thousands of reactions and metabolites. To interpret this complexity, computational modeling becomes an essential experimental tool. …”
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