The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells. by Jennifer Olt, Philomena Mburu, Stuart L Johnson, Andy Parker, Stephanie Kuhn, Mike Bowl, Walter Marcotti, Steve D M Brown

“…Hair bundles show a stair-case structure composed of rows of stereocilia, and each stereocilium contains a core of tightly-packed and uniformly-polarized actin filaments. …”
Get full text

GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. by Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo

“…Delayed homologous chromosome pairing, synaptonemal complex (SC) assembly, and DNA double-strand break repair progression are partially rescued by the expression of human CYTIP in gras-1 mutants, supporting functional conservation. …”
Get full text

Socio-economic and ecological aspects of land management in cities by Olga Petrakovska, Mariia Mykhalova

“…Land relations have always been one of the determining factors of socio-economic development and tightly exist in a single system of socio-economic matters. …”
Get full text

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Proteomics and biochemical reconstitution reveal that Ypl225w functions as a co-translational chaperone by forming dual interactions with the eEF1A G domain nascent chain and the UBA domain of ribosome-bound nascent polypeptide-associated complex (NAC). …”
Get full text

Classification patterns identification of immunogenic cell death-related genes in heart failure based on deep learning by Zhihui Ma, Shixin Ma, Bin Chen, Yongjun Zhang, Jinmei Zeng, Jianping Tao, Yu Hu

“…Abstract Heart failure (HF) is a complex and prevalent condition, particularly in the elderly, presenting symptoms like chest tightness, shortness of breath, and dyspnea. …”
Get full text

Challenges in Management of a Post-Traumatic Stiff Elbow – When to Perform Open Arthrolysis: A Case Report by S Adithyaa, K R Tarun Prashanth, M R Thirunthaiyan, R Dorai Kumar, B Sundararaja

“…The elbow joint is particularly susceptible to stiffness due to its highly congruent bony anatomy, relatively confined joint space tightly stabilizing collateral ligament complex, and the close relationship of the surrounding muscles acting as secondary stabilizers. …”
Get full text

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. by Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann

“…All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. …”
Get full text

Loss of ARID1A leads to a cold tumor phenotype via suppression of IFNγ signaling by Pamela M. Watson, Chelsea A. DeVaux, Kevin W. Freeman

“…Our work clarifies that the loss of ARID1A, which tightly associates with MYCN amplification, causes reduced inflammatory signaling. …”
Get full text

Novel pathogenic mtDNA variants in Chinese children with neurological mitochondrial disorders by Zhimei Liu, Kexin Pan, Mingzhao Wang, Yijun Jin, Wenxin Yang, Keer Chen, Chaolong Xu, Xin Duan, Ying Zou, Changhong Ren, Lifang Dai, Suzhou Zhao, Ya Wang, Lijun Shen, Fang Fang, Hezhi Fang

“…Abstract Objective Pathogenic variations in the mitochondrial genome are tightly linked to neurological mitochondrial disorders in children. …”
Get full text

Exploiting <i>Brassica rapa</i> L. subsp. <i>pekinensis</i> Genome Research by Faujiah Nurhasanah Ritonga, Zeyu Gong, Yihui Zhang, Fengde Wang, Jianwei Gao, Cheng Li, Jingjuan Li

“…However, challenges exist in integrating multi-omics for the functional analysis of genes and for developing potential traits for Chinese cabbage improvement. …”
Get full text

Influence mechanisms of dynamic metamorphism on the evolution of micro/nano pore structures in tectonically deformed coals by Hewu LIU, Xiaoxue LYU, Chenliang HOU, Zuopeng XIONG

“…In detail, the aromatic structures in the TDCs experienced chemical changes like rotation, folding, and recombination, forming a more tightly arranged molecular structural configuration. …”
Get full text

The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride. by Rossana Segreto, Hoda Bazafkan, Julia Millinger, Martina Schenk, Lea Atanasova, Maria Doppler, Christoph Büschl, Mélanie Boeckstaens, Silvia Soto Diaz, Ulrike Schreiner, Fabiano Sillo, Raffaella Balestrini, Rainer Schuhmacher, Susanne Zeilinger

“…Here we describe how alteration of the activity of TOR1, the single and essential TOR kinase of T. atroviride, by treatment with chemical TOR inhibitors or by genetic manipulation of selected TOR pathway components affected various cellular functions. Loss of TSC1 and TSC2, that are negative regulators of TOR complex 1 (TORC1) in mammalian cells, resulted in altered nitrogen source-dependent growth of T. atroviride, reduced mycoparasitic overgrowth and, in the case of Δtsc1, a diminished production of numerous secondary metabolites. …”
Get full text

Effectuation control: Modified management control system for sustainability in facing the uncertainty by Setyarini Santosa, Tubagus Ismail, Imam Abu Hanifah, Munawar Muchlish

“…This study aims to investigate the functioning of joint control by introducing a novel construct known as effectuation control, which forms effectuation MCS. …”
Get full text

Expression pattern of Calbindin-D28k, NeuN proteins, ATOH1 and EN2 genes in the human fetal cerebellum by Phanindra Prasad Poudel, Arnab Ghosh, Chacchu Bhattarai, Saman Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, R. Vani Lakshmi, Sneha Guruprasad Kalthur

“…Background: Human cerebellum plays a crucial role in motor coordination and cognitive functions. Series of events such as cell proliferation, migration, and differentiation occur during the development, which are tightly regulated by specific genes. …”
Get full text

The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma by Nour Abu Jayab, Alaa Abed, Iman M. Talaat, Rifat Hamoudi

“…Background: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. …”
Get full text

Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies by Yang Xinyi, Reshetov Igor Vladimirovich, Narasimha M. Beeraka, Allaka Satyavathi, Dinisha Kamble, Vladimir N. Nikolenko, Allaka Naga Lakshmi, Basappa Basappa, Padmanabha Reddy Y, Ruitai Fan, Junqi Liu

“…Abstract Background Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. …”
Get full text

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling by Elise S Bruguera, Jacob P Mahoney, William I Weis

“…Wnt/β-catenin signaling directs animal development and tissue renewal in a tightly controlled, cell- and tissue-specific manner. …”
Get full text

The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 by Bitong Zhang, Bitong Zhang, Yahui Wang, Yahui Wang, Yahui Wang, Haoxiang Chang, Haoxiang Chang, Chong Wang, Chong Wang, Hong Fan, Hong Fan, Xiuyun Ren, Xiuyun Ren

“…BackgroundPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, involving complex interactions between systemic and local immune responses. …”
Get full text

Integrative and comparative analysis of whole-transcriptome sequencing in circCOL1A1-knockdown and circCOL1A1-overexpressing goat hair follicle stem cells by Jian Wang, Xi Wu, Liuming Zhang, Xiaomei Sun, Wei Sun, Kunzhe Dong, Yongjun Li

“…Objective Hair morphogenesis is tightly related to hair follicle stem cells (HFSCs) proliferation and hair follicle (HF) development. …”
Get full text

THE DYNAMICS STUDY OF PATIENTS STATE WITH MUSCLE AND JOINT DYSFUNCTION OF TMJ, WHICH DECIDED TO COMPLETE THE TREATMENT AFTER ELIMINATION OF THEIR DISEASE SYMPTOMS ACHIEVED BY USING... by A.M. Boyan, V.I. Bessonov

“…Because of the treatment carried out during 3.5 ± 0.7 months, all 25 patients haven’t had any clinical aspects of muscle and joint dysfunction of the TMJ and all of them have had normal physiological functioning of the masticatory muscles and TMJ, which was confirmed by objective examination methods, including special ones. …”
Get full text