Controllable intein splicing and N-terminal cleavage at mesophilic temperatures by Taylor A. McNeal, Joel Weinberger, Geraldy L. S. Liman, Tia M. Ariagno, David W. Wood, Thomas J. Santangelo, Christopher W. Lennon

“…Our results provide an alternative intein-based system – one that does not require either an external nucleophile or prolonged incubation at high temperature to stimulate NTC – that controls intein activity within a temperature range amenable to most mesophilic experimental organisms.…”
Get full text

Evaluation of postoperative pain on Transversus Abdominis Plane block and Erector Spinae Plane block in patients undergoing gynecological surgery: a prospective, comparative study by D. Tavianto, O. M. Pison, Azka Putra Rakhmatullah

“…OBJECTIVES: This study aims to compare postoperative pain in patients undergoing either ESP blocks or TAP blocks, and the need for postoperative morphine in patients undergoing gynecological surgery.MATERIALS AND METHODS: This was a single-center, prospective, double-arm, comparative study. …”
Get full text

Traditional Chinese Medicine Prescription Generation Model Based on Search Enhancement by ZHAO Zijuan, REN Xueting, SONG Kai, QIANG Yan, ZHAO Juanjuan, ZHANG Junlong

“…Although there is a small part of research in this field, transfer learning methods are usually used to apply relevant technology of text generation to this task simply and roughly. Either large number of standardized dataset is needed to train the model, or the domain knowledge and expertise of TCM are required. …”
Get full text

Chemicals That Disrupt the Endocrine System and Their Effects on Behavior by Yousaf Khan1, Abdul Sattar1, Syed Amin Ullah1, Zia-Ur-Rehman2, Hakimullah3, Madeeha Bibi4, Hina Sarfraz1, Anila Mukhtiar1

“…There are certain chemicals which include chlorpyrifos, DDT, insecticides, pesticides, fungicides and other daily use items such as plastics, paints, furniture, perfumes, toys polishes, electronic gadgets, items of food packaging are reported to have disturbed the normal hormonal functions in humans that are leading to numerous diseases due to either lack of production of specific hormone or increased production of a specific hormone by the action of these chemicals. …”
Get full text

Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial by Sara Szupieńko, Aleksandra Buczek, Henryk Szymański

“…A total of 140 children will be randomised (1:1) to receive either hypertonic saline nebulisation (5 mL, three times a day) or normal saline at the same dose. …”
Get full text

The Role of Education in Preventing E-Smoking Behavior is to Increase Student Knowledge and Attitudes by Sri Sunarti, Tukimin bin Sansuwito, Purwo Setiyo Nugroho, Nida Amalia, Rusni Masnina, Linda Suwarni

“…The control group did not exhibit any differences in knowledge or attitudes during either of the two measures that were conducted. It was found that there were variations in knowledge and attitudes between the experimental group and the control group after one month of post-education was delivered.…”
Get full text

Anti-Malarial Effects of Five Traditional Nigerian Medicinal Plant Extracts on Plasmodium Berghei-Infected Rats by Ugochukwu Vincent, Igbokwe, Ejike, Daniel Eze, Moses Dele, Adams, Karimah Mohammed, Rabiu, Iliya, Ezekiel, Prisca Ojochogu, Ajeka, Peace Ogechukwu, Okpara

“…These results give suggestive evidence that the plant extracts either singly or combined, could be a promising anti-plasmodial candidate.…”
Get full text

Unique Design of Learning Studio Spaces: A Case Study of The Department of Applied Design and Fine Art Kabale University. by Akatwijuka, Onesmus

“…Any Interior work done without consideration of space management principles can therefore not be called perfect, which should not even be useful and also durable or durable but not useful, or either having both these should be without beauty. …”
Get full text

Unique Design of Learning Studio Spaces: A Case Study of the Department of Applied Design and Fine Art Kabale University. by Akatwijuka, Onesmus

“…Any Interior work done without consideration of space management principles can therefore not be called perfect, which should not even be useful and also durable or durable but not useful, or either having both these should be without beauty. …”
Get full text

Lessons learned from implementation of the Workload Indicator of Staffing Need (WISN) methodology: An international Delphi study of expert users. by Grace , Nyendwoha Namaganda, Audrey, Whitright, Everd, Bikaitwoha Maniple

“…Results Participants rated seven of the eight technical steps of the WISN as either “very easy” or “easy” to implement. The step considered most difficult was obtaining the Category Allowance Factors (CAF). …”
Get full text

An Overview: Organophosphate Flame Retardants in the Atmosphere by Hsin-Chieh Kung, Yen-Kung Hsieh, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chien

“…Abstract Organophosphate flame retardants (OPFRs) have been adopted as safer alternatives to polybrominated biphenyl ether flame retardants. However, because of their ubiquitous presence in the environment and the growing evidence of health risks, there has been growing research interest in understanding the fate and effects of these compounds in the environment. …”
Get full text

TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…We found that treatment with the TGFβ vaccine not only reduced the percentage of M2-like tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the tumor but polarized CAFs away from the myofibroblast-like phenotype. However, whether the immune modulatory properties of the TGFβ vaccine on TAM and CAF phenotypes are a direct consequence of the recognition and subsequent targeting of these subsets by TGFβ-specific T cells or an indirect consequence of the overall modulation induced within the TME remains unknown. …”
Get full text

Trajectories of self-rated health in an older general population and their determinants: the Lifelines Cohort Study by Barbara C van Munster, Nynke Smidt, Sophia E de Rooij, Marlies Feenstra, Janet L MacNeil Vroomen

“…Trajectories of poor SRH are associated with multimorbidity and unhealthy behaviours. Whether trajectories of SRH are associated with deviating physiological markers is unclear. …”
Get full text

The influence of using fermentated rumen content at quail feed to the protein of yolk and albumen of quail eggs by Gesa Cantya Primatara, Mohammad Anam Al Arif, Tita Damayanti Lestari, Widya Paramita Lokapirnasari, Sri Hidanah, Suharsono Suharsono

“…The aims of this research was to find out whether the usage of fermentation cattle ruminal content in quail’s feed ransom can influence the protein content inside the yolk and albumen of an egg. …”
Get full text

Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial by Sue F Plummer, Iveta Garaiova, Elizabeth A Williams, Bernard M Corfe, Simon Tazzyman, Nicholas Richards, Andrew R Trueman, Amy L Evans, Vicky A Grant

“…Participants were further stratified according to whether they were vitamin D replete or insufficient. …”
Get full text

Assessment attendance and treatment engagement with talking and internet-enabled therapies of people with and without a long-term physical health condition: analysis of Talking The... by Emma Jenkinson, Ruth A. Hackett, Rona Moss-Morris, Grace Wong, Jon Wheatley, Mirko Cirkovic, Joanna Hudson

“…Aims To explore the association between LTC status and assessment attendance, treatment engagement and internet-enabled therapy receipt within Talking Therapies services, and whether receipt of internet-enabled treatment bolsters engagement. …”
Get full text

Predicting cardiovascular disease and all-cause mortality using the lymphocyte-to-monocyte ratio: Insights from explainable machine learning models by Jichao Wu, Die Huang, Jiefang Li, Jingxing Yi, Yu Lei, Jun Yin

“…This study investigates the lymphocyte-to-monocyte ratio (LMR), a simple immune biomarker associated with inflammation, to assess whether it can serve as a new marker for predicting chronic inflammation in cardiovascular disease, and compares it to traditional biomarkers. …”
Get full text

Building evidence for indoor tanning as a behavioral addiction: concerns, problems, and change perceptions are associated with addictive symptoms by Allison Leip, Carolyn J. Heckman, Jerod L. Stapleton

“…However, studies have not adequately explored whether excessive tanning continues despite concerns and problems that would be expected with behavioral addiction. …”
Get full text

Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: explorator... by Anne Bouthillier, Gabriel Bastien, Christina McAnulty, Hamzah Bakouni, Bernard Le Foll, M. Eugenia Socias, Didier Jutras-Aswad

“…Reduction in use without complete abstinence presents a promising avenue for intervention enhancement, but supporting data is scarce regarding its translation into positive patient outcomes. This study explores whether reducing opioid use frequency (OUF) during opioid agonist treatment correlates with reduced potential life problems in individuals with POUD, including those using fentanyl. …”
Get full text

Patient “No-Show” Prior to Elective Primary Total Hip Arthroplasty Increases Risk of Postoperative Anemia by Jeffrey S. Mun, BA, Matthew W. Parry, MD, MS, Alex Tang, MD, Jesse J. Manikowski, MS, Cory Crinella, PA-C, John J. Mercuri, MD, MA

“…Patients were divided based on whether they NS at least 1 appointment vs always attend (AA) appointments. …”
Get full text