Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): A bibliometric study by Kangjie li, Jie Wang, Ming Dang, Runxin Ren, Maomao Fu, Jing Wang, Qiao Zhang, Chongbo Zhao

“…To better understand the evolving role of TCM in treating NAFLD, a comprehensive analysis of existing research is necessary. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Since platelets play an important role in regulating endothelial cell barrier function and over 95 % of the circulating soluble CD40 ligand (sCD40L) is derived from activated platelets, we speculated that the release of CD40L from activated platelets induced by diabetes was the key mechanism that aggravated BBB injury and leaded to DACD. …”
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Innovations and Challenges in Intermediate Respiratory Care Units: Toward Effective Integration into the Hospital System by Beatriz Jara Chinarro, Laura Pazos Rodriguez, Miguel Cuchí Alfaro, Ainhoa Izquierdo Pérez, Silvia Aguado Ibañez, María Churruca Arrospide, Marta Soler Vigil, Cristina Moral, Carlos Almonacid

“…The review analyzes the history and evolution of the IRCUs, their role and function, IRCU models, the evolution of admission criteria, and their efficacy and efficiency.IRCUs offer significant benefits by improving patient outcomes through accurate categorization and specialized treatment of severe pulmonary diseases, ensuring high-quality care. …”
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Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…The findings reported here indicate that VD3S-PEG micelles may have a promising role in PDAC therapy, since VD3 could act not only as a hydrophobic core of the micelles but also as a therapeutic agent that provides synergetic therapeutic effects with the encapsulated PTX.…”
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Evaluation on Carbon Sequestration Capacity of 30 Common Landscaping Tree Species in Beijing by Jing QIAN, Sidong SHEN, Shuxin FAN, Li DONG

“…Landscaping trees play an important role in increasing urban natural carbon sinks and neutralizing urban anthropogenic carbon emissions. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…To examine the alteration of MEF2C transcription by the SNP, we generated HEK293T cells carrying the major or minor allele by CRISPR-Cas9. To verify the role of MEF2C-knockdown (MEF2C-KD) in mice, we developed AAV expressing shRNA for MEF2C based on AAV-U6 promoter vector. …”
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Aflatoxin B1 impairs the growth and development of chicken PGCs through oxidative stress and mitochondrial dysfunction by Ying-Jie Niu, Jun Wu, Wenjie Ren, Guangzheng Liu, Gaoyuan Wu, Yixiu Peng, Dan Zheng, Kai Jin, Qisheng Zuo, Guohui Li, Wei Han, Xiang-Shun Cui, Guohong Chen, Bichun Li

“…Inhibiting NRF2 exacerbated oxidative stress and cell death in PGCs, suggesting NRF2 upregulation plays a protective role under AFB1 regulation. This study illuminates AFB1's toxic effects on chicken PGCs and provides insights into potential mechanisms, establishing a basis for strategies to prevent and treat AFB1's adverse effects on poultry genetic transmission.…”
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Benefits of a second tandem flight phase between two successive satellite altimetry missions for assessing instrumental stability by M. Ablain, N. Lalau, B. Meyssignac, R. Fraudeau, A. Barnoud, G. Dibarboure, A. Egido, C. Donlon

“…<p>Five successive reference missions, TOPEX/Poseidon, Jason-1, Jason-2, Jason-3, and more recently Sentinel-6 Michael Freilich, have ensured the continuity and stability of the satellite altimetry data record. …”
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Microbial mechanisms underlying the reduction of N2O emissions from submerged plant covered system by Yongxia Huang, Min Deng, Shuni Zhou, Yunpeng Xue, Senbati Yeerken, Yuren Wang, Lu Li, Kang Song

“…Further analysis of N2O metabolic rates from nitrification, denitrification, and abiotic processes under light and dark conditions confirmed that counter-diffusion of dissolved oxygen and nutrients in SP biofilms plays a key role in reducing denitrification-driven N2O emissions. …”
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Combined Effects of Humic Acid-Modified Magnetic Biochar and AMF on the Properties of Saline-Alkali Soil and Photosynthetic Parameters of Muskmelon by ZHANG Yating, LOU Xueyi, WU Jiarui, LIU Hongyuan, YE Binyu, XIAO Jiamin, LI Jiameng, MIAO Yining, CHEN Xinyan, LIU Yilin, TAN Yuyu, WANG Zhichao, LIU Peng

“…Under 150 mmol/L saline-alkali stress, applying a low dose of HA-MBC still played a role in ameliorating soil and mitigating stress, while applying high doses of biochar inhibited the improvement of indicators. …”
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Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone − A 2-year field experiment by Zhongjun Xue, Fengfeng Sui, Yanjie Qi, Siyu Pan, Ning Wang, Rongjun Bian, Stephen Joseph, Xuhui Zhang, Lianqing Li, Genxing Pan

“…This study reveals the important role of biochar's elemental composition and properties in soil Cd immobilization and the mitigation of rice Cd uptake.…”
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Editorial by Daniel Halliday

“…Here the authors argue that the Swedish abolition of the tax owes much to the way in which “the identity of the figurative taxpayer” has played a different role in the political narratives around inheritance taxation in both countries. …”
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CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct t... by Mercedes Zubiaur, Laura C. Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-del Jesús, Luz María Canet-Antequera, María M. Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez, Sonia Pérez-Cabrera, Nerea Bello-Iglesias, Antonio Alcina, Ana-Clara Abadía-Molina, Fuencisla Matesanz, Esther Zumaquero, Ramón Merino, Jaime Sancho

“…Overall, these findings support the pro-inflammatory and immunomodulatory role of CD38 during the development of the cGVHD-lupus disease.…”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…Overall, our studies demonstrate the epigenetic regulation function of VSIG4 confers on TAMs an alternative pattern, beyond the checkpoint role of VSIG4, to shape the immunosuppressive tumor microenvironment and impair antigen-specific immunity against aggressive cancers. …”
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Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…Recent studies highlight the AT-rich interactive domain-containing protein (ARID) family, particularly ARID3A, as influential in cancer progression, though its specific role in breast cancer remains unclear. This study investigates ARID3A's expression, prognostic relevance, clinicopathological correlations, co-expression profiles, and protein-protein interactions in breast cancer. …”
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Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep by Beaumelle, Camille, Toïgo, Carole, Papet, Rodolphe, Benabed, Slimania, Beurier, Mathieu, Bordes, Léa, Brignone, Anaïs, Curt-Grand-Gaudin, Nadine, Garel, Mathieu, Ginot, Justine, Jacquiet, Philippe, Miquel, Christian, Poirel, Marie-Thérèse, Serafino, Anna, Vannard, Eric, Bourgoin, Gilles, Yannic, Glenn

“…Our results demonstrated that ibex can host and shed resistant strains before transhumant sheep arrive on pastures, and thus could act as a refuge or even contribute to maintaining resistant gastrointestinal nematodes. The relative role of ibex in the maintenance and circulation of resistant strains in sheep remain to be determined.…”
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Insights on the effect of mega-carcass abundance on the population dynamics of a facultative scavenger predator and its prey by Sidous, Mellina, Cubaynes, Sarah, Gimenez, Olivier, Drouet-Hoguet, Nolwenn, Dray, Stéphane, Bollache, Loïc, Madhlamoto, Daphine, Ngwenya, Nobesuthu Adelaide, Fritz, Hervé, Valeix, Marion

“…Although our results support a predominant role of bottom-up mechanisms, whereby hyaena density is driven by herbivore density, itself driven by resources availability, some subtle patterns of densities could be interpreted as consequences of changes in predation pressure following changes in scavenging opportunities. …”
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Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 by Chenyang Gu, Teng Yao, Chenxian Dong, Zuhai Chen, Wanting Wei, Xiaoju Li, Qiang Niu, Yizhong Yan, Yunhua Hu

“…Mediated analysis was used to explore the mediating role of immune cells in the relationship between phthalate exposure and obesity and its complications. …”
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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…Exo enriched with miR-126-3p demonstrated similar effects as Epi-exo, establishing the crucial role of miR-126-3p in the mechanism of Epi-exo. Dual luciferase reporter assay coupled with gene mutation techniques identified that miR-126-3p was found to target the regulator of G-protein signaling 3 (RGS3) gene. …”
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Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice by Nan Dong, Zhenli Xie, Anqi Wei, Yuxin Yang, Yongning Deng, Xu Cheng, Bianbian Wang, Yang Chen, Yuhao Gu, Jingyu Yao, Yuhao Qin, Chaowen Zheng, Xi Zhang, Yuqing Zhang, Xinjiang Kang, Guoqing Chen, Qiumin Qu, Changhe Wang, Huadong Xu

“…Here, we provide compelling evidence that the compensatory expression of synaptotagmin-11 (Syt11) plays a key role in concealing PD-associated phenotypes in parkin knockout (KO) mouse models. …”
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