Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…Purpose This study aims to elucidate the role of DNAJC12 in intellectual disability and explore the mechanisms by which DNAJC12 deficiency leads to hyperphenylalaninemia through developing a DNAJC12 gene knockout mouse model. …”
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Permafrost pore structure and its influence on microbial diversity: Insights from X-ray computed tomography by Nathan D. Blais, Joy M. O’Brien, Hannah Holland-Moritz, Lauren Farnsworth, Robyn A. Barbato, Thomas A. Douglas, Alexandra Contosta, Julie Bobyock, Erin C. Rooney, Taylor Sullivan, Jessica Gilman Ernakovich

“…Soil pore structure plays a critical role in shaping soil microbial communities, which directly influence biogeochemical cycling. …”
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Modeling Factors Influencing Project Financing Risk by Gholamreza Sharafi, Kiamars Fathi Hafashjani, Faegh Ahmadi

“…Its significance has grown notably in recent decades within the financial market, reflecting its pivotal role in facilitating economic development. Notably, in developing countries, the establishment of robust economic infrastructure is a pressing priority, serving as a cornerstone for overall growth and advancement across multiple economic sectors. …”
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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Additionally, CCRE decreased UVB-induced IL-6 expression and IKK phosphorylation, which play a crucial role in inflammaging. Notably, CCRE treatment also improved cell viability upon UVB exposure and mitigated UVB-induced cell apoptosis, further underscoring its potential to preserve cellular integrity and function in relation to environmental stressors. …”
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Analysis of the Spatial Pattern of Military River Defense on the Ming Great Wall: A Case Study of the Shanxi Section of the Yellow River by Tianlian WANG, Zhe LI

“…ObjectiveRiver defence plays a vital role in the development of the Ming Great Wall’s military defence system. …”
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Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis by Juan Hu, Qiao Li, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao, Yansong Li, Yaomin Zhu

“…Given that imbalances in copper homeostasis and cuproptosis are associated with various neurodegenerative disorders and diabetic myocardial damage, we hypothesize a role for cuproptosis in the pathogenesis of DACD. …”
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Dietary and lifestyle patterns identified through reduced rank regression and their association with insulin-related disorders: a prospective analysis from the Tehran Lipid and Glu... by Ebrahim Mokhtari, Hossein Farhadnejad, Farshad Teymoori, Mitra Kazemi Jahromi, Mehrnaz Nikkhah, Parvin Mirmiran, Fereidoun Azizi

“…Abstract Background Since foods are consumed in combinations that also interact with other lifestyle variables such as body mass index(BMI) and physical activity, it is difficult to separate the role of single foods or a lifestyle variable alone in predicting the risk of chronic diseases such as metabolic disorders. …”
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Structure-activity relationship and in silico docking analysis of dicarboximide fungicides on 17β-hydroxysteroid dehydrogenase 1 of human, rat, and pig by Huiqian Chen, Sailing Chen, Yunbing Tang, Yingfen Ying, Shaowei Wang, Yang Zhu, Yiyan Wang, Ren-shan Ge, Ping Duan

“…The dithiothreitol treatment demonstrated that the formation of irreversible bonds between dicarboximide fungicides and the cysteine residues played a key role in the inhibition of 17β-HSD1 activity. In conclusion, dicarboximide fungicides inhibit 17β-HSD1 depending on lipophilicity, species, and cysteine residue interactions.…”
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CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…The only T cell subset which correlated with a reduction in tumor growth was within Tocky signal positive conventional CD4+, supporting their therapeutic role. Targeting CD25 high, antigen-engaged Treg with a depleting anti-CD25 ICI, achieved complete cures in 100% of mice with triple therapy. …”
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Comprehensive evaluation of the nutritional value and contaminants of alfalfa (Medicago sativa L.) in China by Xiaoyan Zhu, Xiaoyan Zhu, Xiaoyan Zhu, Wenxue Chen, Mengyao Li, Boshuai Liu, Boshuai Liu, Boshuai Liu, Shumin Zhao, Menglin Hu, Jiajing Li, Defeng Li, Defeng Li, Defeng Li, Yinghua Shi, Yinghua Shi, Yinghua Shi, Hao Sun, Hao Sun, Hao Sun, Chengzhang Wang, Chengzhang Wang, Chengzhang Wang

“…IntroductionAlfalfa is used as a feed source for animals and plays an important role in animal nutrition. Nutritional value analysis and contamination evaluation are essential for sustainable utilisation to ensure the quality and safety of alfalfa.AimWe aimed to evaluate the nutritional value and safety of alfalfa in five major regions in China—the Northeast Plain (NP), Inner Mongolia Plateau (IMP), Northwest Desert Oasis (NO), Loess Plateau (LP), and Huanghuaihai Plain (HP).MethodsNinety-five samples representing 44 large-scale pratacultural companies were collected and analysed.ResultsThe average nutritional values of alfalfa hay were 16.43% crude protein (CP), 44.01% neutral detergent fibre (NDF), 33.22% acid detergent fibre (ADF), 10.78% crude ash (Ash), and 91.90% dry matter (DM), which were better in the NO and IMP areas; in particular, the α-linolenic acid value of alfalfa was the highest in the IMP area (p < 0.05). …”
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Digitalisasi Model Sistem Akuntansi Terintegrasi Bagi Usaha Bersama Simpan Pinjam di Kota Kupang by Yustina Alfira Nay, Selfiana Goetha, Maria Goreti Malut

“…Joint Savings and Loans Business (UBSP) has an important role as an investor, especially for housewives who do not have a fixed income. …”
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Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019) by Marina Padilha, Victor Nahuel Keller, Paula Normando, Raquel M Schincaglia, Nathalia C Freitas-Costa, Samary SR Freire, Felipe M Delpino, Inês RR de Castro, Elisa MA Lacerda, Dayana R Farias, Zachary Kroezen, Meera Shanmuganathan, Philip Britz-Mckibbin, Gilberto Kac

“…Background: The role of circulating metabolites on child development is understudied. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…However, the mechanism underlying the effects of SSA in prostate cancer treatment remains elusive.MethodsIn this study, a network pharmacology approach was applied to identify relevant targets from drug- and disease-related databases, and intersections were analyzed using Venny2.1 to construct a Protein-Protein interaction (PPI) interaction network. …”
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The geographical variation in grassland forage quality on the eastern Qinghai-Tibet Plateau is driven mainly by climate by Shulan Wu, Xiaotao Lü, Qinghua Liu, Erke Wuda, Liu Li, Chunzhang Zhao, Juanjuan Huang, Shuang Li, Youbang Hu, Wenzhi Du, Hewen Li, Chaoqun Chen, Lin Luo, Ali Raza, Chunying Yin

“…Conclusions This study highlights the role of climate in driving the variation of forage quality in the alpine grasslands. …”
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Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

“…Meanwhile, the expression of their corresponding target proteins were all decreased in both plasma and tumor tissues of LUAD cases, which may play a role of tumor suppressor proteins. After mutation of 3 pQTL‐SNPs (rs7683000, rs73224660, and rs2776937), the expression of corresponding target proteins BST1 and NRP1 decreased, and as potential tumor suppressor proteins, which may promote tumorigenesis and further increasing the risk of developing LUAD (OR >1, p < 0.05); while after mutation the other pQTL‐SNP rs62069916, the corresponding target protein APOH expression was increased, while as a potential tumor suppressor protein, which may inhibit tumorigenesis and further reduced the risk of developing LUAD (OR <1, p < 0.05). …”
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Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy by Erin L. Fee, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W. Clarke, Demelza J. Ireland, John P. Newnham, Masatoshi Saito, Sebastian E. Illanes, Binny Priya Sesurajan, Liang Shen, Mahesh A. Choolani, Gokce Oguz, Adaikalavan Ramasamy, Sara Ritchie, Andrew Ritchie, Alan H. Jobe, Matthew W. Kemp

“…These data suggest a potential heritable role in determining ANS responsiveness.…”
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Balanced displacement methods and effect evaluation of heterogeneous combination flooding in different reservoirs by Dejun WU, Jian HOU, Lijie LIU, Kang ZHOU, Zhibin AN

“…Heterogeneous combination flooding further played a role in conformance control and oil displacement at different layers, enhancing the sweep effect and improving oil displacement efficiency, effectively extracting the remaining oil controlled by the interbeds. …”
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Interaction of dietary replacements of fishmeal by protein blend and feeding frequency on growth performance and protein utilization of gibel carp (Carassius gibelio var. CAS V) by Yongning Yu, Yu Wang, Junyan Jin, Dong Han, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie

“…Future strategies aimed at replacing dietary fishmeal should consider the role of feeding frequency as a critical factor.…”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…We also infected murine neutrophils to evaluate the expression levels of relevant genes related to the resistance and infection process while facing ROS-related stress. …”
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Machine learning analysis of pathological images to predict 1-year progression-free survival of immunotherapy in patients with small-cell lung cancer by Hirotaka Matsumoto, Hiroaki Akamatsu, Nobuyuki Yamamoto, Yuki Sato, Daichi Fujimoto, Yoshihiko Taniguchi, Motohiro Tamiya, Yasuhiro Koh, Junya Fukuoka, Hisashi Tanaka, Naoki Furuya, Ryota Shibaki, Tsukasa Nozawa, Akira Sano, Yuka Kitamura, Takashi Kijima, Toshihide Yokoyama, Satoru Miura, Akito Hata, Jun Sugisaka

“…The machine learning analysis of the TIME had better accuracy than the human count evaluations (AUC of human count, CD8-positive lymphocyte: 0.681, FoxP3-positive lymphocytes: 0.626, PD-L1 score: 0.567).Conclusions The spatial analysis of the TIME using machine learning predicted the immunotherapy efficacy in patients with SCLC, thus supporting its role as an immunotherapy biomarker.…”
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