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6541
Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice
Published 2025-02-01“…Overall, our study highlights Steap4’s critical role in modulating adipocyte mitochondrial function, thereby controlling thermogenesis, energy expenditure, and adiposity.…”
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6542
Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC
Published 2025-02-01“…BackgroundN6-methyladenosine (m6A) RNA modification is crucial for tumor development and progression; however, which m6A regulators play a pivotal role in head and neck squamous cell carcinoma (HNSCC) remains ambiguous.MethodsUtilizing the Cancer Genome Atlas (TCGA) database, the expression levels of m6A regulators in HNSCC were examined, which led to the identification of heterogeneous nuclear ribonucleoprotein C (HNRNPC) as a key gene. …”
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6543
A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh
Published 2025-02-01“…An expert panel evaluated all reports to determine the role of L. monocytogenes infection in the causal chain of stillbirth. …”
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6544
Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure
Published 2025-01-01“…Conclusions: This study highlights the significant role of beverage consumption in mitigating or exacerbating the T2D risk associated with long-term NO2 and NOX exposure.…”
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6545
Bradykinin B1 receptor signaling triggers complement activation on endothelial cells
Published 2025-02-01“…Blocking the B1R may have a role in reducing complement deposition and its effects on the endothelium.…”
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6546
Providing a General Model for the Successful Implementation of Digital Transformation in Organizations
Published 2024-06-01“…Furthermore, each of these categories and their subcategories were found to play an integral role in the effective implementation process of digital transformation. …”
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6547
Penggunaan Metode Naïve Bayes Classifier pada Analisis Sentimen Penilaian Masyarakat Terhadap Pelayanan Rumah Sakit di Malang
Published 2024-10-01“…The author also employs Root Cause analysis to aid the public and relevant parties in identifying issues and providing problem-solving recommendations. …”
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6548
Efficacy and safety of ketamine and esketamine in reducing the incidence of postpartum depression: an updated systematic review and meta-analysis
Published 2025-02-01“…It is recommended to use smaller doses for a more tolerable treatment period since doses less than 0.5 mg are significantly effective. …”
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6549
Penyeimbangan Kelas SMOTE dan Seleksi Fitur Ensemble Filter pada Support Vector Machine untuk Klasifikasi Penyakit Liver
Published 2023-12-01“…Abstract The liver is one of the important organs in the human body that plays a role in the body's metabolic processes. Quoting an article from the American Liver Foundation website, in 2020, as many as 51,642 adults in the United States died from liver disease. …”
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6550
Physically based modelling of glacier evolution under climate change in the tropical Andes
Published 2025-02-01“…When driven with statistically downscaled climate change projections, the JULES–OGGM simulations indicate that, contrary to point-scale energy balance studies, sublimation plays a very minor role in glacier evolution at the basin scale and does not bring about significant non-linearities in the glacier response to climate warming. …”
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6551
The Autoimmune Profiles in the Etiopathogenesis of Granulomatous Lobular Mastitis
Published 2025-03-01“…Conclusions: The results highlighted the crucial role of elevated M1 and M2 macrophages in GLM inflammation. …”
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6552
Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis
Published 2025-01-01“…Both nascent and long-lived proteins contribute to the elevated protein degradation during compensatory growth slowdown, with long-lived proteins playing a crucial role at the G1/S transition. Notably, large G1/S cells exhibit particularly high efficiency in protein degradation, surpassing that of similarly sized or larger cells in S and G2, coinciding with the timing of the most stringent size control in animal cells. …”
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6553
Unsteady ground: understanding the problem of BPPV in the world of sports
Published 2025-02-01“…It is widely believed though that certain types of movement may play a role in triggering BPPV. Material and methods: This article is based on a comprehensive review of the literature, conducted using PubMed and Google Scholar. …”
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6554
Heterogeneous occurrence of evergreen broad-leaved forests in East Asia: Evidence from plant fossils
Published 2025-01-01“…Evergreen broad-leaved forests (EBLFs) are widely distributed in East Asia and play a vital role in ecosystem stability. The occurrence of these forests in East Asia has been a subject of debate across various disciplines. …”
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6555
Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
Published 2024-02-01“…Due to its crucial involvement in the initial phases of influenza A infections, HA emerges as a promising target in the search of novel drug-like candidates. Given its pivotal role in the early stages of influenza A infections, intense drug discovery efforts have been undertaken to target HA in the past decades. …”
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6556
Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition
Published 2025-01-01“…Inorganic arsenic is a Class I human Carcinogen. However, the role of chronic inorganic arsenic exposure on prostate cancer metastasis still unclear. …”
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6557
Dietary supplementation of Astragalus polysaccharide or its nanoparticles enhances testicular hemodynamics, echotexture, scrotal circumference, concentration of testosterone, estra...
Published 2025-02-01“…Abstract This study investigated, for the first time, the potential role of Astragalus polysaccharide (APS) and APS nanoparticles on testicular blood flow (TBF) and semen quality in Ossimi rams. …”
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6558
Perancangan Disaster Recovery Plan Pada Pusat Data Dan Teknologi Informasi Komunikasi Instansi XYZ
Published 2024-08-01“…Dalam penelitian ini, berdasarkan hasil wawancara dengan pimpinan, ketua tim, dan staf Pusdatik, terungkap bahwa layanan yang dikelola oleh Pusdatik memiliki peran yang krusial dalam mendukung proses bisnis organisasi. …”
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6559
Investigation of gut microbiota in pediatric patients with peanut allergy in outpatient settings
Published 2025-02-01“…The observed shifts in microbial communities, particularly the increase in Proteobacteria and the decrease in beneficial bacteria such as Firmicutes and Bacteroidetes, underscore the potential role of the gut microbiome in the pathogenesis of peanut allergy. …”
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6560
Detecting gene copy number alterations by Oncomine Comprehensive genomic profiling in a comparative study on FFPE tumor samples
Published 2025-02-01“…Abstract Copy number alterations (CNAs) play a fundamental role in cancer development and constitute a potential tool for tailored treatments. …”
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