Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors by Xue Han, Francis Lobo, Michael S. Broder, Eunice Chang, Sarah N. Gibbs, David J. Ridley, Irina Yermilov

“…**Objectives:** To assess real-world treatment persistence in early-line abatacept versus tumor necrosis factor-inhibitors (TNFi) treated patients with RA complicated by poor prognostic factors (including anti-cyclic citrullinated peptide antibodies \[ACPA\] and rheumatoid factor \[RF\] seropositivity). **Methods:** We performed a multi-center retrospective medical record review. …”
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Older, vulnerable patient view: a pilot and feasibility study of the patient measure of safety (PMOS) with patients in Australia by Jeffrey Braithwaite, Natalie Taylor, Rebecca Lawton, Robyn Clay-Williams, Emily Hogden, Zhicheng Li

“…We aimed (1) to investigate the extent to which the PMOS is appropriate for use with stroke, acute myocardial infarction (AMI) and hip fracture patients in Australian hospitals and (2) to pilot the PMOS for use in a large-scale, national study ‘Deepening our Understanding of Quality in Australia’ (DUQuA).Participants Stroke, AMI and hip fracture patients (n=34) receiving care in 3 wards in 1 large hospital.Methods 2 phases were conducted. First, a ‘think aloud’ study was used to determine the validity of PMOS with this population in an international setting, and to make amendments based on patient feedback. …”
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Economic development, alcohol consumption and life expectancy in low- and lower-middle-income countries in the Western Pacific Region: a structural equation modelling study by Jürgen Rehm, Huan Jiang, Ahmed S Hassan, Pol Rovira, Kevin D Shield

“…We examined the role of alcohol consumption in this transition process for lower- and middle-income countries.Methods We tested three hypotheses on the interrelationship between economic growth, level of alcohol consumption and life expectancy in all six countries in the WHO Western Pacific Region, which transitioned from low- to lower-middle-income countries over the past 20 years. …”
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Impact of tourist and recreational activities on the indicators of soil-ecological monitoring of the adjacent territory of Lake Teletskoe (Altai Mountains) by Olga A. Elchininova

“…To assess the current state of a soil cover of the adjacent territory of Lake Teletskoe in terms of tourism and recreation impact. Methods. Comparative geographical and chemical as well as soil-ecological monitoring of studied indicators of early, short- and long-term diagnostics. …”
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Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway by Zhengguo Qiu, Jianbing Ma, Xiaqing Zhang, Mingna Jiao, Liqiang Zhi

“…However, the synergistic effects of EA and TG in CIRI and the underlying mechanism have not been demonstrated. Methods: Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and reperfusion (MCAO/R) to establish a CIRI model. …”
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An assessment of South African policy and strategic framework for the development of a sufficient, equitably distributed and well-performing health workforce for the implementation... by S V Mokoena, P Naidoo

“…To determine whether SA possesses a strong and competent policy and strategic framework that would guide the development of a sufficient, fairly distributed and well-performing health workforce. Methods. A cross-sectional descriptive quantitative study was undertaken using pretested anonymous questionnaires to solicit responses about the ability, strategies and policies needed to address health workforce challenges. …”
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Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…To better understand metabolic disorders and expand the potential targets for MM, we conducted large-scale untargeted metabolomics on plasma samples from MM patients and healthy controls (HC). Methods Our study included 33 HC, 38 newly diagnosed MM patients (NDMM) categorized into three RISS grades (grade I: n = 5; grade II: n = 19; grade III: n = 8), and 92 MM patients post-targeted therapy with bortezomib-based regimens. …”
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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…Therefore, we planned a study with an objective of evaluating safety, tolerability, pharmacodynamics and pharmacokinetics of a novel thienopyridine antiplatelet agent AT-10 in healthy Indian subjects compared with standard dosage regimen of clopidogrel based on their CYP2C19 genotyping.Methods Two CYP2C19 genotype–based groups were identified, that is, poor metabolisers and extensive metabolisers, with 20 subjects in each group (n=40) for participating in a randomised, two-period, crossover study. …”
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Optimizing Soft Tissue Emergence Profile Around One-Piece Dental Implants by Abduljaleel Azad Samad

“…The purpose of this study is to propose a simple way for optimizing soft tissue around one-piece dental implants. Material and Methods: Between January 2022 and January 2024, a total of 137 patients were treated with single-piece dental implants that were placed in the aesthetic anterior region of the mouth. …”
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A Retrospective Observational Cohort Analysis of Oncology Patients with Febrile Neutropenia in the Emergency Department of a Tertiary Care Hospital in Oman by Badar Al-Aamri, Aisha AL Breiki, Darpanarayan Hazra, Talib Al-Aamri, Manar Al-Shehi

“…This study evaluated guideline adherence and clinical outcomes in the management of febrile neutropenia in oncology patients in the emergency department (ED). Methods: This retrospective study was conducted over 4 years. …”
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Association between health insurance coverage and stage of diagnosis for cervical cancer among females in Indiana from 2011 - 2019 by Mrithula Suresh Babu, Monica L. Kasting, Natalia M. Rodriguez

“…This study aimed to assess the extent to which health insurance coverage in Indiana is a contributing factor to the stage of cervical cancer diagnosis. Methods: We examined reported cervical cancer cases among females (N = 2518) using cancer registry data from the Indiana Department of Health from 2011 to 2019. …”
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Organ Donation Conversations on X and Development of the OrgReach Social Media Marketing Strategy: Social Network Analysis by Wasim Ahmed, Mariann Hardey, Josep Vidal-Alaball

“…We use credibility theory to explore the construction and impact of credibility within social media contexts in organ donation discussions. MethodsData were retrieved from X between October 2023 and May 2024, covering a 7-month period. …”
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Blood pressure, gallstones, and age at first cholecystectomy in U.S. adults: a cross-sectional study by Yue Zhang, Ruifeng Duan, Xin Chen, Lijuan Wei

“…This study assessed the association between hypertension (HTN) and both the prevalence of gallstones and the age at first cholecystectomy among U.S. adults. Methods Data were extracted from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020. …”
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The impact of land use transition on ecosystem service value in Lixiahe area: Multi-scenario simulation based on Markov-FLUS model by CHEN Xinwei, LI Hongbo, ZHANG Wenbo, GE Xiaoping

“…In the context of ecological civilization construction, simulating the land use transformation in this region under multiple scenarios and its impact on the value of ecosystem services have practical guiding significance. [Methods] Based on the land cover data of 1990, 2005 and 2020, this paper analyzes the characteristics of land use and changes in ecosystem service value. …”
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Characteristics and outcomes of the screening program of autism spectrum disorder in Primary Healthcare Centers in Bahrain by Muna A. Almohri, Mahmood A. Alawainati, Zahra A. Ayoob, Nayla A. Nasser, Noof A. Abdulaal, Ahmed A. Aldailami, Donya A. Aldailami

“…This study determined the outcomes of ASD screening program in Primary Healthcare Centers (PHCs) in Bahrain. MATERIALS AND METHODS: A cross-sectional study was conducted in 12 of the 27 PHCs in Bahrain. …”
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Using a Two-Steps Clustering and PCA Analysis for Stratified Chronic Non-Cancer Pain Care: A Retrospective Cross-Sectional Study by Peiró AM, Barrachina J, Escorial M, Aguado I, Margarit C, Grimby-Ekman A

“…The aim of this study was to characterize chronic non-cancer pain (CNCP) patients’ states, through an unsupervised cluster analysis, to implement clinical recommendations in pain care.Patients and Methods: Real-world ambulatory CNCP cohort of patients (n = 418) completed a multidimensional patient-reported registry, as part of a routine initial evaluation, in a multidisciplinary academic pain unit. …”
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Changes in the Structural and Functional Albumin Properties in Patients with Decompensated Liver Cirrhosis by A. A. Turkina, M. V. Maevskaya, M. S. Zharkova, V. T. Ivashkin

“…Аim: to conduct a comparative analysis of serum albumin's structural and functional properties in decompensated cirrhotic patients by means of spin prob EPR spectroscopy.Materials and methods. The main study group included 70 patients with decompensated liver cirrhosis and ascites. …”
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Anxiety, Depression, and Stress Reaction/Adjustment Disorders and Their Associations with Healthcare Resource Utilization and Costs Among Newly Diagnosed Patients With Breast Cance... by Dingwei Dai, Henriette Coetzer, Sean R. Zion, Michael J. Malecki

“…**Objectives:** To evaluate the incidence and prevalence of anxiety, depression, and stress reaction/adjustment disorder among patients newly diagnosed with breast cancer, to examine HCRU and costs, and to assess the association of these psychiatric disorders with costs. **Methods:** This retrospective observational cohort study was conducted using a large US administrative claims database with an index date of newly diagnosed breast cancer. …”
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The Impact of Litter Decomposition on Soil Organic Carbon Stability in Coastal Shelter Forests Under Thinning by ZHANG Zixu, HU Dingmeng, LU Yucun, WU Qicong, DONG Zhi, GAO Peng

“…[Objective] To elucidate the characteristics of litter decomposition and changes in soil organic carbon (SOC) fractions under thinning, and to reveal the impact of litter decomposition on the stability of SOC in coastal shelter forests under thinning. [Methods] After three years of thinning, the litter and surface soil (0—20 cm) of coastal shelter forests (Quercus acutissima Carruth. …”
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Scaling up computational thinking skills in computer-assisted language learning (CTsCALL) and its fitness with language learners’ intentions to use virtual exchange: A bi-symmetric... by Amir Reza Rahimi, Ana Sevilla-Pavón

“…It also revealed that language learners, who focused on the key information rather than the details while solving language tasks, as well as recognizing the pattern of task solving and applying them to other tasks, found VE, and CTsCALL to be aligned with their current capabilities, learning environment, and problem-solving skills that mediated their intention to learn and exchange information in this context in the future. …”
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