Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…The PTX-loaded VD3 micelles were hemocompatible and stable after long-term storage in the presence of biorelevant media, and showed higher efficiency to inhibit the tumor growth compared to the approved clinical nanoformulation (Abraxane®) in an in ovo tumor model. The findings reported here indicate that VD3S-PEG micelles may have a promising role in PDAC therapy, since VD3 could act not only as a hydrophobic core of the micelles but also as a therapeutic agent that provides synergetic therapeutic effects with the encapsulated PTX.…”
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Staphylococcus aureus susceptibilities from wounds of patients who use illicit fentanyl by Drew T. Dickinson, Stephen Saw, Lauren Dutcher, Christina Maguire, Adrienne Terico, Margaret Lowenstein, Sonal Patel

“…Compared to patients discharged prior to susceptibility availability, more patients discharged after the reporting of susceptibilities were administered buprenorphine or methadone in the hospital (82.0% vs 51.4%, P < 0.001). …”
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Effect of exercise training on cardiac autonomic function in type 2 diabetes mellitus: a systematic review and meta-analysis by Sohini Raje, G Arun Maiya, Padmakumar R, Mukund A. Prabhu, Krishnananda Nayak, Shivashankara KN, BA Shastry, Megha Nataraj

“…Methods The Preferred Reporting Items for Systematic Review and Meta-Analysis Checklist (PRISMA) was used. …”
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Intraprosthetic Dislocation Following Dual Mobility Total Hip Arthroplasty: A Retrieval Analysis Study by Salar Sobhi, BSc, MD, Alan Kop, MSc, PhD, Moreica Pabbruwe, PhD, Christopher W. Jones, BCom, BEng(Hons), MBBS(Hons), PhD, FRACS, FAOrthA, Michael A. Finsterwald, MD, FMH, FRACS, FAOrthA

“…Routine retrieval analysis identified concerns regarding IPD of modern implants, and scant reporting in the literature led to this retrospective study. …”
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Asymptomatic testing people for SARS-CoV-2 in healthcare facilities: A systematic review by Olabisi A. Oduwole, Glory Bassey, Grace Esebanmen, Samuel Shoyinka, Johnsolomon Ohenhen, Elise Cogo, Nicholas Henschke, Eleanor Ochodo, Martin M. Meremikwu

“…Following the methods for rapid systematic reviews, data were analysed using a fixed effect model, and results of the effect estimate were reported as odds ratios (OR) with their confidence intervals (CI) (95% CI). …”
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Seguridad de los cannabinoides empleados como terapéutica en Odontología: Una revisión de la literatura by Matias Mederos, Alejandro Francia

“…Los artículos incluidos fueron publicados entre 2011 y 2024, 8 de los 9 estudios se centraron en el control del dolor, si se considera la vía de administración, 4 emplearon la vía sistémica y 5 vía tópica. Con respecto al reporte de efectos adversos 2 estudios no lo evaluaron, en 3 no se encontraron, los 4 estudios que reportaron algún efecto todos emplearon los cannabinoides mediante vía sistémica. …”
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Health and Educational Inequalities among the Third Gender Community in Lahore, Pakistan by Ayesha Humayun, Muhammad Hassan, Hira Ashfaq, Zulqarnain Haider, Nauman Naeem, Mubashar Munir

“…Healthcare discrimination is prevalent, with many reporting neglect and derogatory treatment from both public healthcare providers and paramedical staff, though private healthcare services offer better experiences for those who can afford them. …”
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Evaluating the risk of bacterial infections associated with the most handled Iraqi notes in Kalar by Hassan Mohammad Tawfeeq, Mohammed Hassan Fatah, Ahmed Mohammed Tofiq

“…Every day new sources of microbial and especially bacterial infections are reported, which are not taken into account, the fact that these sources have been implicated in the outbreaks of these infections. …”
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Preoperative vs Postoperative Patient Outcome and Recovery Expectations of Total Joint Arthroplasty by Siddhartha Dandamudi, BBA, Kyleen Jan, MD, Madelyn Malvitz, BS, Anne DeBenedetti, MSc, Omar Behery, MD, MPH, Brett R. Levine, MD, MS

“…Expectations of long-term pain differed: 48.3% of preoperative patients expected no pain and 1.7% expected to be unable to move; postoperatively, 7.3% (P < .0001) reported no pain and 10.3% (P = .03) were unable to move; 17.3% of patients finished PT within 2 weeks, compared to 1.7% who believed this was possible (P =.0027). …”
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THE EFFECT OF TRANEXAMIC ACID INJECTION ON HEMOGLOBIN LEVEL, ALBUMIN LEVEL, AND PAIN ON PATIENT RECEIVING TOTAL KNEE REPLACEMENT by Dwikora Novembri Utomo, Teddy Heri Wardhana, Ahmad Hannan Amrullah, Hamzah Hamzah

“…In the group receiving tranexamic acid, 32 (100%) reported low postoperative VAS scores, did not require blood transfusions and did not require albumin transfusion. …”
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Liver cystic echinococcosis: A retrospective study on the demographics and clinical profile of patients managed at a single tertiary institution in central Eastern Cape Province, S... by A Govindasamy, P R Bhattarai, J van Niekerk, J John

“…The demographics, clinical characteristics and management of patients with liver CE are reported. Results. A total of 56 patients diagnosed with and managed for liver CE were included in the study. …”
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Engaging primary care physicians in system change – an interpretive qualitative study in a remote and rural health region in Northern British Columbia, Canada by David Snadden, Trish Reay, Neil Hanlon, Martha MacLeod

“…Interviews were coded and analysed interpretively to develop common themes.Setting This research is part of a larger study, Partnering for Change I, which investigated the efforts of Northern Health, a rural regional health authority in British Columbia, to transform its healthcare system to one grounded in primary care with a focus on interdisciplinary teams. It reports how physician engagement was accomplished during the first 3 years of the study.Participants Interviews with 34 individuals with direct involvement and experience in the processes of physician engagement. …”
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Infant outcomes after exposure to Tdap vaccine in pregnancy: an observational study by Helen Petousis-Harris, Tony Walls, Patricia Graham, Nicola Austin, Linda Hill

“…Information was obtained from objective sources including routine health visits and vaccination records wherever possible, as well as frequent parental reports.Setting The Canterbury region of New Zealand.Patients A cohort of 403 infants whose mothers had received Tdap vaccine.Main outcome measures Gestational age at birth, growth parameters, congenital anomalies, immunisation status and timeliness of immunisation, development of pertussis infection.Results There were no significant differences in birth weight, gestational age at birth, congenital anomalies or infant growth as compared with baseline population data. …”
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Endoscopic Biopsy in Differential Diagnosis of Colorectal Serrated Lesions by K. D. Khalin, M. Yu. Agapov, L. V. Zvereva, K. V. Stegniy

“…However, histological reports for endoscopic biopsy and resected lesions are not reliably consistent.Aim. …”
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Metabarcoding the night sky: Monitoring landscape-scale insect diversity through bat diet by Cynthia Tobisch, Svenja Dege, Bernd Panassiti, Julian Treffler, Christoph Moning

“…Widespread declines of terrestrial insects are reported across habitats and are associated with drivers at the landscape scale. …”
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Acupoint stimulation for postpartum breastfeeding insufficiency: a systematic review and meta-analysis by Ya-Ching Chang, Yi-An Wang, Zi-Yu Chang, Jian-An Liao

“…Adverse effects were reported in only one trial, which included three cases of fear of acupuncture and one case of hypotension. …”
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Increasing trend of antimicrobial resistance among methicillin-resistant Staphylococcus aureus strains in Southwest Finland, 2007–2016: An analysis of shifting strain dynamics and... by Jaakko Silvola, Kirsi Gröndahl-Yli-Hannuksela, Tiina Hirvioja, Kaisu Rantakokko-Jalava, Mari Kanerva, Kari Auranen, Harri Marttila, Jenna Junnila, Jaana Vuopio

“…Objective: Substantial rise in the annual incidence of methicillin-resistant Staphylococcus aureus (MRSA) was reported in Southwest Finland (12.4–24.9/100,000 people) between 2007 and 2016. …”
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Trial protocol of an open-label pilot study of oral naltrexone–bupropion combination pharmacotherapy for the treatment of methamphetamine use disorder (the NABU trial) by Jonathan Brett, Paul S Haber, Nicholas Lintzeris, Didier Jutras-Aswad, Nadine Ezard, Brendan Clifford, Krista J Siefried, Adrian John Dunlop, Liam Acheson, Carl Moller, Michael Christmass, Kirsten Morley, Steven Shoptaw, Madhukar H Trivedi

“…One recent randomised controlled trial conducted in the USA examined a combination of bupropion and naltrexone not readily available globally. Here, we report a trial protocol for an oral formulation of combined naltrexone and bupropion.Methods and analysis This single-arm, open-label pilot study will assess the safety and feasibility of oral naltrexone and bupropion (40 mg/450 mg daily in divided doses) in adults with methamphetamine use disorder. …”
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Ecotoxicity of lanthanides to Daphnia magna: insights from elemental behavior and speciation in a standardized test medium by Vignati, Davide A.L., Martin, Loïc A., Poirier, Laurence, Zalouk-Vergnoux, Aurore, Fouque, Chantal, Bojic, Clément, Hissler, Christophe, Cossu-Leguille, Carole

“…The present paper provides the first report on the ecotoxicity of all lanthanides (except Pm) for the freshwater crustacean Daphnia magna along with an unprecedented level of detail on LN speciation in the exposure medium. …”
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Medial sural artery perforator free flap for small- to medium-sized defects in head and neck reconstruction: a suitable replacement for radial forearm free flap by Yulian Zhang, Keran Pan, Jian Wu, Xi Tang

“…The patients were assessed subjective donor-site morbidity and satisfaction with overall functional results using a self-reported questionnaire. Results The success rates of RFF flaps and MSAP flaps were 96% and 95.2%. …”
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