Introduction by Anne Marie Devlin, Katie Ní Loingsigh, T.J. Ó Ceallaigh, Aisling O'Donnell

“…Bliain bhisiúil agus thairbheach ab ea í dúinn mar eagarthóirí, agus tá ríméad orainn i ngeall ar an líon mór páipéar ar ardchaighdeán a fuarthas i nGaeilge agus i mBéarla. Léiriú ar dhíogras agus ar dhúthracht iar-eagarthoirí na hirise is ea rannpháirtíocht láidir an phobail léinn. …”
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NAD⁺激活SIRT3/IDH2信号通路改善高血压血管内皮功能障碍 by 丘雨旻, 陈曦, 张建宁, 刘张弛, 朱秋霞, 张美信, 陶军, 吴杏

“…采用迁移实验和划痕实验评估体外内皮细胞功能；采用免疫荧光染色法检测mtROS水平；采用RT-PCR检测mtDNA、SIRT3、异柠檬酸脱氢酶2（IDH2）的mRNA表达；采用酶联免疫吸附法检测8-羟基-2'-脱氧鸟苷的水平；采用Western blot法检测p-eNOS、eNOS、SIRT3、IDH2蛋白表达水平。…”
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Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced... by Yoon-Young Sung, Won-Kyung Yang, Jong Hoon Kim, Dongseok Shin, Seok June Son, Seung-Hyung Kim

“…Particulate matter (PM, diameter < 10 μm) and Diesel exhaust particles (DEP) exposure can cause severe respiratory disorders. …”
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Structured reporting of neuroendocrine tumors in PET/CT using [18F]SiTATE - impact on interdisciplinary communication by Anna Hinterberger, Lukas Trupka, Sophia Kortbein, Ricarda Ebner, Nicola Fink, Matthias F. Froelich, Dominik Nörenberg, Carmen Wängler, Björn Wängler, Ralf Schirrmacher, Adrien Holzgreve, Matthias Brendel, Stefanie Corradini, Christoph Auernhammer, Johannes Rübenthaler, Freba Grawe

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A scalable multi-modal learning fruit detection algorithm for dynamic environments by Liang Mao, Liang Mao, Zihao Guo, Mingzhe Liu, Yue Li, Linlin Wang, Jie Li

“…A sliding slice method is then employed to predict image targets, thereby reducing the miss rate of small targets.ResultsExperimental results demonstrate that the proposed model improves accuracy, recall, and mean average precision (mAP) by 9.5, 0.9, and 12.3 percentage points, respectively, compared to the original YOLOv5s model. …”
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Influence of Secondary Inorganic Aerosol on the Concentrations of PM2.5 and PM0.1 during Air Pollution Episodes in Hanoi, Vietnam by Nguyen-Quoc Dat, Bich-Thuy Ly, Trung-Dung Nghiem, Thu-Thi Hien Nguyen, Kazuhiko Sekiguchi, Truong-Thi Huyen, Thai-Ha Vinh, Le-Quang Tien

“…In this study, the periods when daily PM2.5 concentrations exceeded the NAAQS of 50 µg m−3 for a minimum of two consecutive days were determined as episode periods. …”
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Association of blood manganese and selenium levels with hepatic steatosis among adolescents: a nationwide cross-sectional analysis by Bin You, Bin You, Bin You, Bin You, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen, Zhiyuan Chen

“…Hepatic steatosis was defined as a controlled attenuation parameter (CAP) score of ≥248 dB/m, a measure of liver steatosis, which is a primary characteristic and a less severe stage of hepatic steatosis, assessed by vibration-controlled transient elastography (VCTE). …”
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Transcriptome Analysis of Effect of Cordyceps militaris Aqueous Extract in Human Gastric Cancer Cell BGC-823 on Different RCD Pathways by Mingqi CUI, Kaiwen YU, Yang SONG, Fangxu XU, Shenghou WANG, Ze WANG

“…Cytological examination revealed typical apoptotic morphological characteristics in gastric cancer cells treated with the XG water extract, with an early apoptotic rate reaching 24.8%, while cell cycle arrest occurred at the G2/M stage. qRT-PCR showed that the expression of BCL2, BCL2L1, CASP3, CASP9, and XIAP was significantly inhibited (P<0.01), whereas that of ENDOG and AIF was significantly upregulated (P<0.01), consistent with the results of transcriptome sequencing. …”
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Bacteraemia in a Nigerian hospital: Implementing antimicrobial resistance surveillance by Adewale A. Amupitan, Adeyemi T. Adeyemo, Adefunke O. Amupitan, Temitope O. Obadare, Aaron O. Aboderin

“…Sixteen (30.2%) of 53 Gram-negative isolates were extended-spectrum beta-lactamase producers, predominantly harbouring blaCTX-M, three (5.7%) were AmpC beta-lactamase producers, and 20 (37.7%) were carbapenem-resistant, predominantly harbouring blaKPC. …”
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Prevalence of Hyper virulence and Multidrug resistance Klebsiella pneumoniae isolates from UTI patients by Manar Abdul karim, Zainab Mohammed Alzubaidy, Khazal Dabua Wadi

“…Serial dilutions were generated, and the resulting MIC values were found to be 512 and 1024µg/mL, respectively. The production of extended-spectrum beta-lactamases (ESBLs) was assessed through the utilisation of the double disc synergy test. …”
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High Stability Single-Port Dual Band Microwave Sensor Based on Interdigital Capacitor Structure With Asymmetry Branch Feedline by Syah Alam, Indra Surjati, Lydia Sari, Raden Deiny Mardian, Teguh Firmansyah, Muhammad Iqbal, Slamet Widodo, Mudrik Alaydrus, Zahriladha Zakaria

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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Results RT-qPCR results showed that PTEN expression was significantly increased in RCC tumor tissues compared to normal tissues (p < 0.01). However, PTEN mRNA levels were significantly reduced in 786-O cells compared to HK-2 cells (p < 0.01). …”
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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

“…After adjusting for age, sex, dose (mg/m2), infusion duration, HDMTX course, and baseline estimated glomerular filtration rate, it remained significant for AKI with an OR of 1.29 and 95% confidence interval of 1.03–1.65. …”
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Effect of Transcranial Direct-Current Stimulation and Task-Oriented Training on Electroencephalography-Based Motor Recovery Chronic Stroke: A Randomized Clinical Trial by Maryam Zolghadr, Shohreh Noorizadeh Dehkordi, Javad Sarrafzadeh, Saeed Talebian, Hassan Haddadzade Niri, Marzieh Yassin

“…Materials and Methods: Thirty chronic hemiparetic stroke survivors were randomly assigned to receive real or sham stimulation targeting the primary motor cortex (C3/C4) at 2 mA for 20 minutes and TOT daily over 15 sessions. …”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…VPA inhibited the transcription of lipogenic genes and these lipogenic genes showed significant decreases in promoter chromatin accessibility only in the IDH1 MT glioma cell lines tested. VPA inhibited the mTOR pathway and a key lipogenic gene, fatty acid synthase (FASN). …”
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Wind Field Retrieval From Co-Polarized SAR Imagery Without External Wind Direction Assistance by Xianen Wei, Jinsong Chong, Yawei Zhao, Lijie Diao, Xuan Jin

“…Similarly, the RMSE and the absolute value of Bias of wind speed comparison with ECMWF and ASCAT were both within 2.5 and 0.65 m/s, respectively. The retrieved wind direction was relatively consistent with the buoy wind direction, but there was a significant deviation in wind speed comparison. …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…The levels of both CXCL8 mRNA and its protein IL-8 in cancer cells under conditions of glucose deficiency were increased in an NF-κB-dependent manner. …”
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Percepción y manejo de la muerte descendente de mango (Mangifera indica L.) en Actopan, Veracruz, México by Juan Carlos Noa-Carrazana, Norma Flores-Estévez, Felipe Roberto Flores-de la Rosa, Luis Guillermo Hernández-Montiel, Liliana Eunice Saucedo-Picazo

“…El análisis de conglomerados permitió identificar tres grupos distintos de productores: pequeños (PPM, 56 %), medianos (MPM, 16 %) y grandes (GPM, 28 %) productores de mango, cada uno con características específicas en cuanto a superficie de cultivo, manejo agronómico y rendimiento (M = 8,54 ± 3,75 t/ha). La  muerte descendente fue reconocida por todos los productores encuestados; los principales síntomas asociados con la enfermedad son: gomosis, pudrición de ramas y tronco. …”
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Utilizing A Multi-Stage Transition Model for Analysing Child Stunting in Two Urban Slum Settlements of Nairobi: A Longitudinal Analysis, 2011-2014. by Oduro, Michael S., IddiI, Samuel, Asiedu, Louis, Asiki, Gershim, Kadengye, DamazoT.

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Assessment of Hand-Hygiene Practices Among Health Care Workers at Kisoro Hospital, Kisoro District. by Nsenga, Alex

“…Specific objectives of the study were; to examine the level of knowledge of health workers on hand-hygiene practice, to determine the level of adherence to hand-hygiene practice among health workers and to identify key barriers m implementation of hand-hygiene practice among health workers at Kisoro hospital in Kisoro District. …”
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