Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival by Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng, Wei Huang

“…Overexpression of HDAC11 and the use of the autophagy activator rapamycin further validated that the HDAC11/IL10 axis regulates mitophagy via the mTOR pathway, which is essential for supporting S. aureus intracellular survival. …”
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Inter-individual Variability in Psychological Outcomes of Supervised Exercise in Adults with Type 2 Diabetes / Variabilidad interindividual en los efectos psicológicos del ejercici... by Marco Guicciardi, Romina Lecis, Davide Massidda, Lucina Corgiolu, Adelina Porru, Matteo Pusceddu, Francesca Spanu

“…La autoeficacia y la percepción de estrés se relacionan con las barreras para realizar ejercicio en pacientes T2DM; por lo tanto, el objetivo de este estudio longitudinal consiste en investigar las variaciones a través del tiempo y las diferencias individuales en ambas variables, como efectos de un entrenamiento de ejercicio supervisado (6 meses), en una muestra pequeña de pacientes diagnosticados con TD2M. Los resultados muestran una disminución general de los valores promedio de la autoeficacia y del estrés percibido a los 6 meses y una alta variabilidad individual en ambas variables. …”
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Scaling of fractured rock flow. Proposition of indicators for selection of DFN based flow models by Davy, Philippe, Le Goc, Romain, Darcel, Caroline, Selroos, Jan-Olof

“…A 4th indicator on the representative elemental volume could in principle be defined but the data show that this volume/scale is beyond the 300 m investigated. We tested a series of numerical models built in three steps: the geo-DFN based on the observed fracture network, the open-DFN which is the part of the geo-DFN where fractures are open, and a transmissivity model applying on each fracture of the open-DFN (Discrete Fracture Network). …”
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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

“…Single-cell functional analysis elucidated the involvement of MAP3K genes in shaping the tumor microenvironment. miRNA-mRNA network analysis revealed intricate regulatory mechanisms, with hsa-mir-200b-3p emerging as a key regulator. …”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis by Salvatore Dimonte, Paywast Jamal Jalal, Hiwa Abdulrahman Ahmad, Safa Bakr Karim, Taib Ahmed Hama Soor, Salar Ibrahim Ali, Muhammed Babakir-Mina, Francesco Greco

“…The phylogenetic trees for all human coronaviruses with the novel Coronavirus have been built using a several complete amino acid sequences of the four known structural proteins, S (spike), E (envelope), M (membrane), and N (nucleocapsid). The result of the study revealed that the SARS-CoV2 is related to human SARS-CoV isolated from different countries very cloely, especially those strains recovered from China in recent times, 2020. …”
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Ultralight aircraft and conventional digital cameras as an alternative for urban mapping by Román Edén Parra-Galaviz, Manuel de Jesús Pérez-Valdez, Omar Llanes-Cárdenas, Lennin Enrique Amador-Castro, Rafael Macías-Segura, Ciro de la Concepción Díaz-Hernández, Alberto Gaxiola

“…A 70 km2 city was mapped using a conventional 39-megapixel camera mounted on a ULAC at 1000 m altitude to validate these tools. Digital processing yielded a ground resolution of 19.7 cm/pixel and root mean square errors (RMSE) of 32 cm in planimetry and 25 cm in altimetry.Additionally, the calibration parameters of the camera used were obtained. …”
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Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…Moreover, qRT-PCR validation confirmed that the mRNA expression of the five biomarkers was consistent with bioinformatics results. …”
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Saussurea gossypiphora extracts reduce inflammation by reversing inflammatory cytokine levels in in-vitro and in-vivo by Kalyani Jatoth, Pawan Kumar Anoor, Ramesh Kande, Sandeepta Burgula

“…Results: The analysis of GC–MS of MESGD revealed the presence of various bio-active components such as Spirohexane-1-Carboxylic acid, ethyl ester; 1-Methyl-1-n-decycloxy-1-silacyclobutane; 1, 2, 4-Trioxolane-2-octanoic acid, 5-octyl, methyl ester; DPPH assay showed inhibition of free radicals by 40 - 95.66 % in the range of 25 – 1000 µg/mL concentrations, comparable with Ascorbic acid. …”
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The effect of depth data and upper limb impairment on lightweight monocular RGB human pose estimation models by Gloria-Edith Boudreault-Morales, Cesar Marquez-Chin, Xilin Liu, José Zariffa

“…The models were trained, validated and tested using the CMU Panoptic and Human3.6 M data sets as well as a custom data set. The custom data set includes RGB-D and optical motion capture data of 15 uninjured and 12 post-stroke individuals, while they performed movements involving their upper limbs. …”
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Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…As a result, dFONs made from PPDs that combine unprecedented brightness (up to 108 M-1·cm-1 and 106 GM), remarkable colloidal stability and absence of toxicity, have been elaborated, providing superior substitutes to Quantum Dots. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Also, VWF and ITGB2 were significantly related to the clinical features, including age, serum creatinine level, and GFR (MDRD). Besides, mRNA and protein expression levels of ITGB2 in HG-treated HK-2 cells were remarkably elevated. …”
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Distribution Characteristics and Coupling Relationship Between Soil Erosion and Hydrologic and Sediment Connectivity in Changchong River Basin by LI Jianing, ZHANG Hongli, TIAN Changyuan, ZHANG Yi, ZHA Tonggang

“…Among the hydrological and sediment connectivity grades, the proportion of 5° ~ 10° and 10° ~ 15° slope, 90.30 ~ 131.96 and 131.96 ~ 175.34 m elevation area is higher. The higher the grade, the higher the proportion of sunny slope area is. (4) Soil erosion has a significant positive correlation with hydrologic and sediment connectivity, mainly reflected in slope, slope direction, land use and elevation. …”
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Selective suppression of influenza A/H5N1 virus replication <i>in vitro</i> using nanocomplexes consisting of siRNA and aminopropylsilanol nanoparticles by Marina N. Repkova, Asya S. Levina, Oleg Yu. Mazurkov, Elena V. Makarevich, Ekaterina I. Filippova, Natalya A. Mazurkova, Valentina F. Zarytova

“…The most effective nanocomplex that contained siRNA targeted at the chosen region of mRNA segment 5 of the viral genome reduced virus replication in the culture by a factor of 630. …”
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Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2 by Jiaqi Sheng, Depei Wu, Jingzhe Shang, Xiaodan Fu, He Gao, Jianjie Rong, Jun Wang, Jiancheng Hu, Xiaofei Qi

“…Conducted Co-IP and ubiquitination experiments for mechanism elucidation. Quantified IgM and IgG using ELISA and FC. Explored public databases for potential correlation molecules. …”
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Yoruba Epistemology, Art, Language and the Universe of Meanings: A Meta-Analysis by Michael O. Afolayan

“…The paper reminds one of the title of the memoir of Ellen DeGeneres, the famous American comedian, titled Seriously . . . I’m Kid[1]ding. Even as a non-apologist of Ellen DeGeneres, or of any other American comedian for that matter, one would find profound meaning to that title, and embrace it as very deep and philosophical. …”
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Preparation of Sea-buckthorn Oil Microcapsule Composite Film and the Preservation Effect of Hand-grabbed Mutton by Bingbing ZHANG, Guishan LIU, Delang XIE, Haiyang MA, Yang LI, Fang MA, Xiaojun LI, Qingqing CAO, Xiaoxue LI, Qian ZHANG

“…Results showed that the embedding rate and yield of sea buckthorns oil microcapsules were 88.94% and 76.28%, respectively, and the optimum conditions for preparing the membrane were 6 g/100 mL gelatin concentration. The ratio of gelatin to glycerin was 1:0.4 and the drying conditions were 20 ℃ for 48 h. …”
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Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

“…Moreover, we aimed to investigate whether these effects change with age.Design Cross-sectional, exploratory.Setting University Clinic, Integrative Research and Treatment Centre.Participants We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women).Main outcome measures VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC).Results We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. …”
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A Performance Evaluation and Inter-laboratory Comparison of Community Face Coverings Media in the Context of COVID-19 Pandemic by Soleiman Bourrous, Mathieu Barrault, Victor Mocho, Stéphane Poirier, Nathalie Bardin-Monnier, Augustin Charvet, Dominique Thomas, Alexandre Bescond, Axel Fouqueau, Tatiana Mace, François Gaie-Levrel, François-Xavier Ouf

“…This specification imposes a minimal air permeability of 96 L m−2 s−1 for a 100 Pa pressure drop and a minimal filtration efficiency of 70% for 3 µm diameter particles. …”
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Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes by Aishat Omobolanle Olatunji, Root Oluwapelumi Alegbe, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Afisu Basiru, Jamila Abdulhamid Atata, Kolawole Yusuf Suleiman, Charles Amoto Shuaibu

“…Group 1(DW) received distilled water (2mL/kg) only. Group 2 (STZ; untreated), group 3 {MET; metformin (Glucophage)}, group 4 {HS; Hibiscus sabdariffa (400mg/kg)}, group 5 {DAF; daflon-500® (1000mg/kg)}, group 6 {DAF+HS; daflon-500® (1000mg/kg) and Hibiscus sabdariffa (400mg/kg)}, group 7 {DAF+MET+HS; daflon-500® (1000mg/kg), metformin (Glucophage), and Hibiscus sabdariffa (400mg/kg)}. …”
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Navigating the future of agri-food supply chain: A conceptual framework using bibliometric review by Abdul Kafi, Nizamuddin bin Zainuddin, Mohd Fitri Mansor, Mohamed Najib Bin Salleh, Adam bin Mohd Saifudin, Nurhaizal Azam Arif, Syairah Aimi Shahron, Ravi Ramasamy, Ibrahim Hassan mohamud

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