Advancements in the Treatment of Mucopolysaccharidoses: From Established Therapies to Gene Therapy by Joanna Wanat, Wojciech Homa, Aleksandra Warunek, Gabriela Gronowicz, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Weronika Zielińska, Michał Chról

“…Among the promising new treatments are: blood-brain barrier (BBB)-penetrable enzyme replacement therapy (ERT), substrate reduction therapy, nonsense suppression therapy, and mRNA engineering. However, the most advanced treatments, that are currently under investigation are in-vivo and ex-vivo gene therapy. …”
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Tectonometamorphic evolution of a subduction plate interface at the base of the Mirdita Ophiolite (Bajram Curri, northeastern Albania) by Madeline Richter, Kilian Pollok, Kujtim Onuzi, Kamil Ustaszewski

“…In northeast Albania near Bajram Curri, a 200–700 m thick metamorphic sole is preserved at its base. …”
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Optimization of the Fermentation Process for Pine-needle Sweet-potato Glutinous Rice Wine and Analysis of Its Antioxidant Activity by Jie YOU, Rusheng XIE, Weibin WU

“…Results: The optimized fermentation conditions were as follows: pine needle mass addition of 3.3%, initial sugar content of 22.5°Bx, fermentation time of 7 d, yeast mass addition of 0.20%, solid (raw material mass):liquid (distilled water volume) ratio of 1:3 (g/mL), and fermentation temperature of 30 ℃. Under these conditions, the resulting pine-needle sweet-potato glutinous rice wine had a total sugar content of 12.5 g/L, alcohol content of 17.6%, and amino acid nitrogen content of 0.58 g/L. …”
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Optimizing Operating Room Efficiency for Primary Hip and Knee Arthroplasty Using Performance Benchmarks by Koorosh Kashanian, BMSc, Matey Juric, BSc, Tim Ramsay, PhD, Pascal Fallavollita, PhD, Paul E. Beaulé, MD, FAAOS, FRCSC

“…All surgeries were performed as outpatients and included 160 females and 135 males; 161 TKA and 134 THA; mean age, 66.1; mean body mass index, 28.6 kg/m2; American Society of Anesthesia, 2. Time points, demographics, and adverse events were recorded. …”
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Hydrogen production by methane decomposition over Ni-doped activated carbons: effect of the activation method by Mahmoudi, Marwa, Dufour, Anthony, Bettahar, Mohammed El-Miloud, Medjahdi, Ghouti, Ouederni, Abdelmottaleb, Gadiou, Roger

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FeO–alumina catalyst for reforming waste polyethylene terephthalate (PET) pyrolyzed products: synthesis, characterization, and performance evaluation by Audu, Ephraim Akuaden, Ade-Ajayi, Adebola Femi, Osigbesan, Aisha Ayoola, Gano, Zaharaddeen Sani, Barminas, Jeffrey Tsware

“…Scanning electron microscopy analysis of catalysts revealed particle sizes of 1.42–7.63, 1.37–10.75, and 2.66–6.34 μm for alumina, 3% FeO/Al, and 5% FeO/Al, respectively. …”
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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…Subsequent miRNA sequencing reveals that ML-EVs exert their effects by delivering miR-27b-3p, which targets ROR1 mRNA in chondrocytes and suppresses downstream NF-κB pathways. …”
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Structural Characterization and Antioxidant Activity in Vivo of Polysaccharides from the Leaves of Hippophae rhamnoides L. by Niannian SONG, Yuxin YI, Xiaoping ZHANG, Bo YANG, Mangsier SAINAWAER, Abuduwaili AYITUXUN

“…HRLP were extracted by water extraction and alcohol precipitation method, and homogeneous polysaccharide (HRLP-2) was obtained through DEAE-650M anion exchange column chromatography. The structure of HRLP-2 was identified based on the analysis of liquid chromatography, gas chromatography, UV, infrared spectroscopy, circular dichroism, Congo red experiment, as well as partial acid hydrolysis, periodate oxidation, and Smith degradation methods. …”
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Identification of natural and anthropogenic factors in the spatial pattern of Pb in the surface soil of the Nanliu River Basin by Xu Liu, Zhongfang Yang, Huading Shi, Tiansheng Wu, Tao Yu, Bo Li, Lei Wang, Yuxiang Shao, Zexin He, Minghui Xie, Chenning Deng

“…When the distance band of the Local Moran's I is set at 8000 m, the most reasonable spatial partitioning characteristics are exhibited. …”
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Defining the sensitivity of cosmic ray muons to groundwater storage changes by Tramontini, Matías, Rosas-Carbajal, Marina, Zyserman, Fabio Iván,  Longuevergne, Laurent, Nussbaum, Christophe, Marteau, Jacques

“…In this work we employ for the first time, the muography method to investigate groundwater variations at the scale of 100 m. We study a mountainous karstic aquifer in the Mont Terri Underground Rock Laboratory (URL), Switzerland. …”
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Conservation networks do not match the ecological requirements of amphibians by Matutini, Florence, Baudry, Jacques, Fortin, Marie-Josee, Pain, Guillaume, Pithon, Josephine

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Effect of the adhesive added of copper applied with electric current on the ceramic/resin cement bond by Gabriel Augusto Silveira Sousa, Marcos Henrique Ramos da Silva, Lourenço Correr-Sobrinho, Rafael Pino Vitti, Evandro Piva, Rafael Leonardo Xediek Consani

“…Adhesive photoactivation was made with 1,200 mW/cm² irradiance for 20 s. A tube-shaped silicone matrix was placed on the ceramic and filled with photoactivated resin cement. …”
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Molecular dynamics simulation of temperature and concentration distribution at liquid-gas interface during liquid air storage process by Zhanping You, Menghan Cheng, Changjie Ma, Yufei Xiao, Xuemin Zhao, Camila Barreneche, Xiaohui She

“…As the heat flux increases from 0.0 to 2.4 W/m2, evaporation rate rises from 0.13 to 0.2 % and the oxygen concentration at the liquid-gas interface reaches 22.3 %. …”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…As per the Revised Evaluation Criteria for Clinical Efficacy in Solid Tumors (mRECIST) criteria, the objective remission rate in Group A was significantly higher than that in Group B (86.6% vs 33.4%). …”
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“A one-stop shop”: Real-world use and app-users' experiences of a psychoeducational smartphone app for adults with ADHD by Christina Seery, Rachel Hannah Cochrane, Martha Mulcahy, Ken Kilbride, Margo Wrigley, Jessica Bramham

“…Fourteen app-users, nine of whom identified as women and five as men, with an age range of 26–65 (M = 40.29, SD = 11.14), participated in semi-structured interviews. …”
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Chemical Pressure-Induced enhancement of electrochemical performance in Ni1-X CuxTe2 (X = 0 and 0.10) layered compounds by Rajkumar Sokkalingam, Manikandan Krishnan, Jesman Sthevan Kovil Pitchai, Sivakumar Periyasamy, Arjun Kumar Bojarajan, Arumugam Sonachalam, Sambasivam Sangaraju

“…The X-ray powder diffraction (XRPD) patterns revealed that both compounds have a CdI2-type trigonal structure with a P3m1 space group. The field emission scanning electron microscope (FESEM) images depicted the layered structure of these compounds. …”
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Associations of the Need for Surgery in Emergency Department Patients with Small Bowel Obstructions by Daniel J. Berman, Alexander W. Mahler, Ryan C. Burke, Andrew E. Bennett, Nathan I. Shapiro, Leslie A. Bilello

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Effect of cardanol on the physical and chemical properties of sodium caseinate-coated papers for packaging applications by Jihyeon Hwang, Yeon-Ji Jo, Dowan Kim

“…Consequently, with increasing CL content, the hydrophobicity of the CasNa/CL-coated papers is enhanced with a reduction in the water-vapor transmittance rate from 461.3 ± 2.0 to 389.8 ± 3.9 g/m2·day and an increase in the water contact angle from 56.6 ± 2.4° to 72.9 ± 1.1°. …”
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A Synoptic- and Remote Sensing-based Analysis of a Severe Dust Storm Event over Central Asia by Parya Broomandi, Kaveh Mohammadpour, Dimitris G. Kaskaoutis, Aram Fathian, Sabur F. Abdullaev, Vladimir A. Maslov, Amirhossein Nikfal, Ali Jahanbakhshi, Bakhyt Aubakirova, Jong Ryeol Kim, Alfrendo Satyanaga, Alireza Rashki, Nick Middleton

“…The extremely high PM concentrations (PM10 > 10,000 µg m−3 in Tashkent) could endanger both human health and the environment, especially in a region suffering from high susceptibility to wind erosion and significant land degradation and desertification. …”
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Atomic Force Microscopy (AFM) nanomechanical characterization of micro- and nanoplastics to support environmental investigations in groundwater by Massimiliano Galluzzi, Michele Lancia, Chunmiao Zheng, Viviana Re, Valter Castelvetro, Shifeng Guo, Stefano Viaroli

“…Advanced spectroscopic techniques can detect the polymer type and quantify the number of MNP particles but are affected by large uncertainties in case of particles smaller than 10 μm in size and MNP heteroaggregates. To advance in the morphological and mechanical characterization of MNPs, a new protocol based on multifrequency Atomic Force Microscopy (AFM) is proposed with the support of the custom open software “MultiFreq AFMSuite”. …”
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