SUMO-Specific Peptidase 5 Promotes Oesophageal Squamous Cell Carcinoma Growth through the NF-κB-SLC1A3 Axis by Chaoxiang Du, Yunfan Hu, Xinyu Yang, Zhe Zhang, Jianmin Gu, Tao Zhang, Renfeng Wang, Shaoyuan Zhang, Lijie Tan, Guiping Yu

“…Stable SENP5-knockdown (KD) cell lines and conditional knockout (cKO) mice were established to verify the biological function of SENP5. …”
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Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize by Manigben Kulai Amadu, Yoseph Beyene, Vijay Chaikam, Pangirayi B. Tongoona, Eric Y. Danquah, Beatrice E. Ifie, Juan Burgueno, Boddupalli M. Prasanna, Manje Gowda

“…Genomic prediction revealed moderate to high prediction accuracies under optimum and drought conditions. …”
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TESTING POTATO COLLECTION SAMPLES FOR THE PRESENCE OF GENES FOR RESISTANCE TO PHYTOPATHOGENS BY MEANS OF DNA MARKERS by A. B. Saynakova, M. S. Romanova, S. N. Krasnikov, O. V. Litvinchuk, Ya. I. Alekseev, A. V. Nikulin, E. V. Terentjeva

“…The development of a multiplex PCR technique and using it to simultaneously test varieties and breeding lines for several genes that control the resistance to viruses and nematodes is a new approach to using DNA markers. …”
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Model-based fed-batch cultivation of Viola odorata plant cells exhibiting antimalarial and anticancer activity by R. Babu, Manokaran Veeramani, Wallepure Aadinath, Vignesh Muthuvijayan, Shailja Singh, Smita Srivastava

“…Bioprocess principles can be applied to develop sustainable methods for the commercial production of high-quality V. odorata plant biomass.MethodsTo this effect, the in vitro culture conditions of V. odorata were rationally optimized to increase the biomass production up to 21.7 ± 0.8 g DW L−1 in 12 days in shake flasks. …”
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Call for Papers: Intergenerational Justice Prize 2020 by FRFG, IF (Foundation for the Rights of Future Generations, Intergenerational Foundation)

“…• How (un)popular are (high) inheritance and gift taxes among voters? Can this topic be used to win elections? …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…The A549 and H1299 cell lines were stimulated with lipopolysaccharide (LPS) and adenosine triphosphate (ATP) to activate the NLRP3 pathway. …”
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Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…Trastuzumab-resistant HER2-positive HCC1954 and SKBR3 breast cancer cell lines were generated and analysed for <i>ITGB3</i> expression heterogeneity. …”
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Cost drivers associated with autologous stem-cell transplant (ASCT) in patients with relapsed/refractory diffuse large B-cell lymphoma in a Japanese real-world setting: A structura... by Saaya Tsutsué, Shinichi Makita, Hiroya Asou, Shingo Wada, Wen Shi Lee, Dilinuer Ainiwaer, Koki Idehara, Sona-Sanae Aoyagi, Seok-Won Kim, Todd Taylor

“…The study design included a follow-up period of up to 24 months with subsequent lines of therapies using retrospective nationwide claims data from the Medical Data Vision Co., Ltd. …”
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Evaluating H2BC9 as a potential diagnostic and prognostic biomarker in head and neck squamous cell carcinoma by Lanhua Wu, Liang Li, Mingjing Zhu, Ziyan Zhou, Xuejin Su, Yueming Jiang, Min Kang, Li Jiang

“…Results H2BC9 was markedly upregulated in HNSCC cell lines and tissues. High expression of H2BC9 was correlated with advanced-stage disease and poor prognosis. …”
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint pr... by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…Recent evidence demonstrated that galectin-9 is highly expressed in a wide range of human malignancies including the most aggressive tumors, such as high-grade glioblastomas and pancreatic ductal adenocarcinomas, as well as common malignancies such as breast, lung and colorectal cancers. …”
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Designing a Future Study Model: Examining Bank Employees’ Attitudes Towards Job Security in the Era of Blockchain Technology (Horizon 2031) by Saeid Ghazi Nezhad, Hasan Darvish, Mohammad Mahmoudi Meymand

“…Research FindingsTo identify the factors influencing the bank employees’ attitudes towards job security in the face of blockchain technology on the horizon of 2031, the following steps were undertaken: 1) Research question formulation: The research questions were developed in line with the main objective of the study. They aimed to explore the dimensions and indicators necessary to identify the factors affecting bank employees' attitudes towards job security in the context of blockchain technology by the year 2031. 2) Literature search: A comprehensive search was conducted to gather relevant domestic and international scholarly articles and books. …”
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Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells by Chen Yuan, Yin Liqi, Hao Mingxuan, Xu Wenkai, Gao Jixian, Sun Yuxin, Wang Qiao, Chen Shi, Liang Youfeng, Guo Rui, Zhang Jinku, Li Jinmei, Zhai Qiongli, Cheng Runfen, Wang Jiansong, Wang Haifeng, Yang Zhao

“…Bladder cancer (BC) is the tenth most commonly diagnosed cancer. High recurrence, chemoresistance, and low response rate hinder the effective treatment of BC. …”
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Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers by Weiping Ji, Ye Fang, Liwei Chen, Yitong Zheng, Yifei Pei, Changqiu Mei, Meng Zhou

“…Here, we conducted a pan-cancer analysis integrating multi-omics data from cell lines, single-cell RNA sequencing, and pan-cancer and immunotherapy datasets to explore the dynamic interplay between m6A modification and TEX. …”
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Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis by Julia Vullings, Juliana P. Vago, Claire E. J. Waterborg, Rogier M. Thurlings, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Flavio A. Amaral, Fons A. J. van de Loo

“…Moreover, stratification analysis showed high sTyro3 levels positively correlated with higher DAS28-ESR and in RF and ACPA double positive RA patients. …”
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Deciphering Gas Dynamics and Star Formation in a z = 1.1 Main-sequence Spiral Galaxy with ALMA and JWST by Zhaoran Liu, Tadayuki Kodama, Takahiro Morishita, Kianhong Lee, Fengwu Sun, Mariko Kubo, Zheng Cai, Yunjing Wu, Zihao Li

“…We present a joint analysis of high-resolution CO(2–1) and Paschen- α (Pa α ) emission lines to trace gas dynamics and spatially resolved star formation in ASPECS-LP.3 mm.06, a z = 1.1 main-sequence galaxy. …”
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Pan-cancer and experimental analyses reveal the immunotherapeutic significance of CST2 and its association with stomach adenocarcinoma proliferation and metastasis by Dan Huang, Jing Li, Zhijun He, Wenjing Liang, Likun Zhong, Jun Huang, Yinteng Wu, Shijian Zhao

“…Single-cell analysis reveals high expression of CST2 in fibroblasts. CST2 is closely associated with prognosis, immune cell infiltration, immune-related genes, mutations, methylation, TMB, and MSI. …”
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A prognostic signature of Glutathione metabolism-associated long non-coding RNAs for lung adenocarcinoma with immune microenvironment insights by Junxi Hu, Junxi Hu, Shuyu Tian, Shuyu Tian, Qingwen Liu, Qingwen Liu, Jiaqi Hou, Jiaqi Hou, Jun wu, Jun wu, Xiaolin Wang, Xiaolin Wang, Yusheng Shu, Yusheng Shu

“…High-risk patients showed increased tumor mutation burden (TMB) and stemness, emphasizing the potential of personalized immunotherapy to improve survival outcomes.…”
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Lactoferrin Modulates Radiation Response Under Hypoxic Conditions, Possibly Through the Regulation of ROS Production in a Cell Type-Specific Manner by Daitoku Murakami, Takahiro Fukazawa, Michihito Kyo, Mutsumi Miyauchi, Shigehiro Ono, Tomonao Aikawa, Nobuyuki Hirohashi, Keiji Tanimoto

“…In this study, we focused on the molecular mechanisms of LF functions in cells under hypoxic conditions. High-dose LF treatment showed cytotoxic activity in a variety of cells, including both non-cancer and cancer cells. …”
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Autism common variants associated with white matter alterations at birth: cross-sectional fixel-based analyses of 221 European term-born neonates from the developing human connecto... by Hai Le, Alexandra F. Bonthrone, Alena Uus, Daphna Fenchel, Alexandra Lautarescu, Konstantina Dimitrakopoulou, A. David Edwards, Joseph V. Hajnal, Serena J. Counsell, Lucilio Cordero-Grande, Daan Christiaens, Dafnis Batalle, Maximilian Pietsch, Anthony N. Price, Hamel Patel, Charles Curtis, Harriet Cullen, Maria Deprez, Jacques-Donald Tournier

“…Abstract Increasing lines of evidence suggest white matter (WM) structural changes associated with autism can be detected in the first year of life. …”
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The Potential Proallergenic Activity of Tranzschelia pruni-spinosae and Phragmidium rubi-idaei in vitro Studies by Sztandera-Tymoczek M, Wdowiak-Wróbel S, Świderska U, Palusińska-Szysz M, Szuster-Ciesielska A

“…Immunofluorescence techniques were employed to assess cell integrity markers.Results: Extracts from T. pruni-spinosae and P. rubi-idaei significantly stimulated the production of proinflammatory cytokines IL-1β and GM-CSF in both cell lines, all of which are associated with the development of allergic responses. …”
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