Maintenance therapy for pediatric patients with high-risk Rhabdomyosarcoma: A report of dose reductions and dose omissions on outcome

Maintenance therapy for pediatric patients with high-risk Rhabdomyosarcoma: A report of dose reductions and dose omissions on outcome

Introduction: In the multicenter, open-label, randomized, controlled, phase 3 trial RMS2005, maintenance chemotherapy (MC), defined as vinorelbine (VNL) and low-dose cyclophosphamide (CPM), has been tested in high-risk patients affected by Rhabdomyosarcoma (RMS). The trial's results have shown...

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Bibliographic Details
Main Authors: Daniela Di Carlo, Lisa Lyngsie Hjalgrim, Beatrice Coppadoro, Michela Casanova, Andrea Ferrari, Véronique Minard-Colin, Hans Merks, Gianni Bisogno
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EJC Paediatric Oncology
Subjects:
Maintenance chemotherapy
Rhabdomyosarcoma
Children
Cumulative dose
Relative dose intensity
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X2500008X
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