Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation
This Letter to the Editor explores synergistic mechanisms enhancing mRNA cancer vaccine efficacy through bile acid metabolism modulation in liver cancer treatment. The latest evidence indicates that bile acids significantly impair T cell function within the liver cancer microenvironment, creating an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/5/502 |
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| author | Yuqian Wang Rui Han Changquan Ling |
| author_facet | Yuqian Wang Rui Han Changquan Ling |
| author_sort | Yuqian Wang |
| collection | DOAJ |
| description | This Letter to the Editor explores synergistic mechanisms enhancing mRNA cancer vaccine efficacy through bile acid metabolism modulation in liver cancer treatment. The latest evidence indicates that bile acids significantly impair T cell function within the liver cancer microenvironment, creating an immunosuppressive milieu that hampers anti-tumor responses. Modulating bile acid composition, particularly increasing ursodeoxycholic acid (UDCA), could reshape the tumor microenvironment (TME) to favor mRNA vaccine-induced T cell activity—a promising strategy to overcome current immunotherapy limitations in liver cancer. |
| format | Article |
| id | doaj-art-f7c82b070f744fcabc08c6f70b7d92f3 |
| institution | DOAJ |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-f7c82b070f744fcabc08c6f70b7d92f32025-08-20T03:12:14ZengMDPI AGVaccines2076-393X2025-05-0113550210.3390/vaccines13050502Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid ModulationYuqian Wang0Rui Han1Changquan Ling2School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaDepartment of Traditional Chinese Medicine Oncology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, ChinaSchool of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaThis Letter to the Editor explores synergistic mechanisms enhancing mRNA cancer vaccine efficacy through bile acid metabolism modulation in liver cancer treatment. The latest evidence indicates that bile acids significantly impair T cell function within the liver cancer microenvironment, creating an immunosuppressive milieu that hampers anti-tumor responses. Modulating bile acid composition, particularly increasing ursodeoxycholic acid (UDCA), could reshape the tumor microenvironment (TME) to favor mRNA vaccine-induced T cell activity—a promising strategy to overcome current immunotherapy limitations in liver cancer.https://www.mdpi.com/2076-393X/13/5/502bile acidmRNA cancer vaccineliver cancercombinatorial therapeutic approach |
| spellingShingle | Yuqian Wang Rui Han Changquan Ling Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation Vaccines bile acid mRNA cancer vaccine liver cancer combinatorial therapeutic approach |
| title | Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation |
| title_full | Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation |
| title_fullStr | Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation |
| title_full_unstemmed | Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation |
| title_short | Unlocking mRNA Vaccine Potential in Liver Cancer Treatment via Synergistic Bile Acid Modulation |
| title_sort | unlocking mrna vaccine potential in liver cancer treatment via synergistic bile acid modulation |
| topic | bile acid mRNA cancer vaccine liver cancer combinatorial therapeutic approach |
| url | https://www.mdpi.com/2076-393X/13/5/502 |
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