CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis

CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis

Abstract Background ANCA-associated glomerulonephritis (AAGN) is a leading cause of uremia in children, driven by macrophages (Mφs) that mediate crescent formation and fibrosis. Despite their critical role, the signals governing monocyte recruitment and macrophage polarization in AAGN remain unclear...

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Main Authors: Zilin Liu, Yongqi Deng, Xiaomei Song, Xin Cai, Huaying Xiong, Liwen Tan, Shengsen Wei, Qiulin Li, Xiong Wang, Wei Jiang, Yaxi Chen, Qiu Li, Mo Wang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Efferocytosis
Macrophage
CXCL12
CXCR4
Fibrosis
Anca-associated glomerulonephritis
Online Access:https://doi.org/10.1007/s00018-025-05750-5
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