Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration
Aim. The purpose of this study was to analyze changes in MCP-1 as a marker of fibrosis and MMP-9 as an indicator of fibrolysis in patients with CRS and with a background of CHF and type 2 diabetes, depending on the level of glomerular filtration rate. Methods and results. 80 patients with CHF FC...
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Zaporizhzhia State Medical and Pharmaceutical University
2014-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/28757/25742 |
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| author | P. G. Kravchun A. V. Narizhnaya N. G. Rindina |
| author_facet | P. G. Kravchun A. V. Narizhnaya N. G. Rindina |
| author_sort | P. G. Kravchun |
| collection | DOAJ |
| description | Aim. The purpose of this study was to analyze changes in MCP-1 as a marker of fibrosis and MMP-9 as an indicator of fibrolysis in patients with CRS and with a background of CHF and type 2 diabetes, depending on the level of glomerular filtration rate.
Methods and results. 80 patients with CHF FC II-III with coronary heart disease (CHD) and who were treated in the cardiology department of the Kharkiv City Clinical Hospital № 27 were examined (mean age 65,13±8,66 years). The first group included 46 patients with CHF diagnosed with type 2 diabetes, the second - 34 CHF patients without diabetes. The study excluded patients with acute coronary syndrome and acute myocardial infarction. MCP-1 was determined by ELISA using a reagent kit «HUMAN MCP-1» (eBiocience,Austria). MMP-9 was determined by ELISA using a reagent kit «HUMAN MMP-9» (eBiocience,Austria).
Conclusion. Progression in patients with type 2 CRS on a background of heart failure and type 2 diabetes associated with a proportional increase fibrosis marker MCP-1, indicating its involvement in tubulointerstitial renal disease. High levels of MMP-9 in patients with type 2 CRS on a background of heart failure and type 2 diabetes in the presence of GFR> 60 mL/min were detected. Reduced GFR <60 mL/min. was not accompanied by a further increase in the activity of an antifibrotic factor. MCP-1 hyperactivity resulted in a cascade of reactions of the progression of interstitial sclerosis. |
| format | Article |
| id | doaj-art-ee947e9ee3bc499c99bfccc7df7abd1f |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-ee947e9ee3bc499c99bfccc7df7abd1f2025-08-20T03:21:12ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102014-10-0152427http://dx.doi.org/10.14739/2310-1210.2014.5.28757Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtrationP. G. Kravchun A. V. NarizhnayaN. G. RindinaAim. The purpose of this study was to analyze changes in MCP-1 as a marker of fibrosis and MMP-9 as an indicator of fibrolysis in patients with CRS and with a background of CHF and type 2 diabetes, depending on the level of glomerular filtration rate. Methods and results. 80 patients with CHF FC II-III with coronary heart disease (CHD) and who were treated in the cardiology department of the Kharkiv City Clinical Hospital № 27 were examined (mean age 65,13±8,66 years). The first group included 46 patients with CHF diagnosed with type 2 diabetes, the second - 34 CHF patients without diabetes. The study excluded patients with acute coronary syndrome and acute myocardial infarction. MCP-1 was determined by ELISA using a reagent kit «HUMAN MCP-1» (eBiocience,Austria). MMP-9 was determined by ELISA using a reagent kit «HUMAN MMP-9» (eBiocience,Austria). Conclusion. Progression in patients with type 2 CRS on a background of heart failure and type 2 diabetes associated with a proportional increase fibrosis marker MCP-1, indicating its involvement in tubulointerstitial renal disease. High levels of MMP-9 in patients with type 2 CRS on a background of heart failure and type 2 diabetes in the presence of GFR> 60 mL/min were detected. Reduced GFR <60 mL/min. was not accompanied by a further increase in the activity of an antifibrotic factor. MCP-1 hyperactivity resulted in a cascade of reactions of the progression of interstitial sclerosis.http://zmj.zsmu.edu.ua/article/view/28757/25742Chronic Heart FailureDiabetes MellitusCardiorenal SyndromeMatrix Metalloproteinase-9Chemokine CCL2 |
| spellingShingle | P. G. Kravchun A. V. Narizhnaya N. G. Rindina Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration Zaporožskij Medicinskij Žurnal Chronic Heart Failure Diabetes Mellitus Cardiorenal Syndrome Matrix Metalloproteinase-9 Chemokine CCL2 |
| title | Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration |
| title_full | Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration |
| title_fullStr | Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration |
| title_full_unstemmed | Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration |
| title_short | Monocyte chemoattractant protein-1 and matrix metalloproteinase-9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration |
| title_sort | monocyte chemoattractant protein 1 and matrix metalloproteinase 9 in patients with type 2 cardiorenal syndrome with chronic heart failure and diabetes type 2 depending on the rate of glomerular filtration |
| topic | Chronic Heart Failure Diabetes Mellitus Cardiorenal Syndrome Matrix Metalloproteinase-9 Chemokine CCL2 |
| url | http://zmj.zsmu.edu.ua/article/view/28757/25742 |
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