A Computational Cognitive Biomarker for Early-Stage Huntington's Disease.

A Computational Cognitive Biomarker for Early-Stage Huntington's Disease.

Huntington's disease (HD) is genetically determined but with variability in symptom onset, leading to uncertainty as to when pharmacological intervention should be initiated. Here we take a computational approach based on neurocognitive phenotyping, computational modeling, and classification, i...

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Main Authors: Thomas V Wiecki, Chrystalina A Antoniades, Alexander Stevenson, Christopher Kennard, Beth Borowsky, Gail Owen, Blair Leavitt, Raymund Roos, Alexandra Durr, Sarah J Tabrizi, Michael J Frank
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0148409
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