Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice

Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice

ObjectiveThis study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy pathways in diabetic mice.Methodsdb/db diabetic mice were administered PAItrap3 (5.7 mg/kg/day, IV) for 21 consecutive days, and its impact on metabolic, gene expression, and...

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Bibliographic Details
Main Authors: Linxi Wang, Zhouyangyang Zhang, Menghua Lin, Liqin Qi, Libin Liu, Zhuo Chen, Shuzhi Tang, Lijing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
PAI-1 inhibitor
lipid metabolism
autophagy
energy metabolism
diabetes mellitus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1596655/full
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