Degradation modeling of degradable copolymers for biomimetic scaffolds
Abstract Biomimetic scaffolds provide a suitable growth environment for tissue engineering and demonstrate good potential for application in biomedical fields. Different-sized copolymerized biomimetic scaffolds degrade differently, and the degradation rate is affected by the copolymerization ratio....
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2019-07-01
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| Series: | Friction |
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| Online Access: | http://link.springer.com/article/10.1007/s40544-019-0291-5 |
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| _version_ | 1850263030032498688 |
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| author | Taohong Zhang Yue Gao Lingling Zhu Qingfeng Zeng Ming Zhou |
| author_facet | Taohong Zhang Yue Gao Lingling Zhu Qingfeng Zeng Ming Zhou |
| author_sort | Taohong Zhang |
| collection | DOAJ |
| description | Abstract Biomimetic scaffolds provide a suitable growth environment for tissue engineering and demonstrate good potential for application in biomedical fields. Different-sized copolymerized biomimetic scaffolds degrade differently, and the degradation rate is affected by the copolymerization ratio. The study of the degradation property is the foundational research necessary for realizing individualized biomimetic scaffold design. The degradation performance of polyesters with different copolymerization ratios has been widely reported; however, the modeling of this performance has been rarely reported. In this research, the degradation of copolymers was studied with multi-scale modeling, in which the copolymers were dispersed in a cellular manner, the chain break time was simulated, and the chain selection was based on the Monte Carlo (MC) algorithm. The probability model of the copolymer’s chain break position was established as a “roulette” model, whose probability values were estimated by the calculation of the potential energy difference at different chain break positions by molecular dynamics that determined the position of chain shear, thereby fully realizing the simulation of the chain micro-break process. The diffusion of the oligomers was then calculated using the macro diffusion equation, and the degradation process of the copolymer was simulated by three-scale coupling calculations. The calculation results were in good agreement with the experimental data, demonstrating the effectiveness of the proposed method. |
| format | Article |
| id | doaj-art-eaa8b90ec2ab473c9482afa4f53a1f6c |
| institution | OA Journals |
| issn | 2223-7690 2223-7704 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Friction |
| spelling | doaj-art-eaa8b90ec2ab473c9482afa4f53a1f6c2025-08-20T01:55:04ZengTsinghua University PressFriction2223-76902223-77042019-07-018359460310.1007/s40544-019-0291-5Degradation modeling of degradable copolymers for biomimetic scaffoldsTaohong Zhang0Yue Gao1Lingling Zhu2Qingfeng Zeng3Ming Zhou4Computer Department, School of Computer & Communication Engineering, University of Science and Technology Beijing (USTB)Computer Department, School of Computer & Communication Engineering, University of Science and Technology Beijing (USTB)Computer Department, School of Computer & Communication Engineering, University of Science and Technology Beijing (USTB)Computer Department, School of Computer & Communication Engineering, University of Science and Technology Beijing (USTB)State Key Laboratory of Tribology, School of Mechanical Engineering, Tsinghua UniversityAbstract Biomimetic scaffolds provide a suitable growth environment for tissue engineering and demonstrate good potential for application in biomedical fields. Different-sized copolymerized biomimetic scaffolds degrade differently, and the degradation rate is affected by the copolymerization ratio. The study of the degradation property is the foundational research necessary for realizing individualized biomimetic scaffold design. The degradation performance of polyesters with different copolymerization ratios has been widely reported; however, the modeling of this performance has been rarely reported. In this research, the degradation of copolymers was studied with multi-scale modeling, in which the copolymers were dispersed in a cellular manner, the chain break time was simulated, and the chain selection was based on the Monte Carlo (MC) algorithm. The probability model of the copolymer’s chain break position was established as a “roulette” model, whose probability values were estimated by the calculation of the potential energy difference at different chain break positions by molecular dynamics that determined the position of chain shear, thereby fully realizing the simulation of the chain micro-break process. The diffusion of the oligomers was then calculated using the macro diffusion equation, and the degradation process of the copolymer was simulated by three-scale coupling calculations. The calculation results were in good agreement with the experimental data, demonstrating the effectiveness of the proposed method.http://link.springer.com/article/10.1007/s40544-019-0291-5copolymer for biomimetic scaffoldscopolymerization ratiodegradation modelingmulti-scale modelprobability model for chain break location |
| spellingShingle | Taohong Zhang Yue Gao Lingling Zhu Qingfeng Zeng Ming Zhou Degradation modeling of degradable copolymers for biomimetic scaffolds Friction copolymer for biomimetic scaffolds copolymerization ratio degradation modeling multi-scale model probability model for chain break location |
| title | Degradation modeling of degradable copolymers for biomimetic scaffolds |
| title_full | Degradation modeling of degradable copolymers for biomimetic scaffolds |
| title_fullStr | Degradation modeling of degradable copolymers for biomimetic scaffolds |
| title_full_unstemmed | Degradation modeling of degradable copolymers for biomimetic scaffolds |
| title_short | Degradation modeling of degradable copolymers for biomimetic scaffolds |
| title_sort | degradation modeling of degradable copolymers for biomimetic scaffolds |
| topic | copolymer for biomimetic scaffolds copolymerization ratio degradation modeling multi-scale model probability model for chain break location |
| url | http://link.springer.com/article/10.1007/s40544-019-0291-5 |
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