Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host
Dairy products often serve as matrices for delivering probiotic bacteria to humans through the diet; however, little is known about the impact of milk fat globules on the growth and survival of probiotic microorganisms. This review discusses current knowledge on the structure and functionality of th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/2/223 |
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| author | Withanage Prasadini Wasana Mark Waterland David W. Everett Caroline Thum |
| author_facet | Withanage Prasadini Wasana Mark Waterland David W. Everett Caroline Thum |
| author_sort | Withanage Prasadini Wasana |
| collection | DOAJ |
| description | Dairy products often serve as matrices for delivering probiotic bacteria to humans through the diet; however, little is known about the impact of milk fat globules on the growth and survival of probiotic microorganisms. This review discusses current knowledge on the structure and functionality of the milk fat globule membrane (MFGM) and the structural components contributing to the mechanisms of interactions with probiotic bacteria. We analyzed studies published between 2001 and 2025 with reference to earlier foundational research on probiotics and MFGM structure to explore the functional significance of MFGM–probiotic interactions. Recent research indicates that the effects of MFGM interaction with bacteria are species-specific and may influence probiotic activity in the host, including enhancing probiotic viability during intestinal transit and modulating probiotic colonization. In general, research findings suggest that the MFGM holds potential for use as a probiotic carrier to the gut with beneficial health consequences. |
| format | Article |
| id | doaj-art-e928a39980244ef5a3a390f1e97062cc |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-e928a39980244ef5a3a390f1e97062cc2025-08-20T02:44:56ZengMDPI AGMicroorganisms2076-26072025-01-0113222310.3390/microorganisms13020223Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human HostWithanage Prasadini Wasana0Mark Waterland1David W. Everett2Caroline Thum3Food Function and Physiology Team, AgResearch, Palmerston North 4410, New ZealandSchool of Food Technology and Natural Sciences, Massey University, Palmerston North 4410, New ZealandRiddet Institute, Massey University, Palmerston North 4410, New ZealandFood Function and Physiology Team, AgResearch, Palmerston North 4410, New ZealandDairy products often serve as matrices for delivering probiotic bacteria to humans through the diet; however, little is known about the impact of milk fat globules on the growth and survival of probiotic microorganisms. This review discusses current knowledge on the structure and functionality of the milk fat globule membrane (MFGM) and the structural components contributing to the mechanisms of interactions with probiotic bacteria. We analyzed studies published between 2001 and 2025 with reference to earlier foundational research on probiotics and MFGM structure to explore the functional significance of MFGM–probiotic interactions. Recent research indicates that the effects of MFGM interaction with bacteria are species-specific and may influence probiotic activity in the host, including enhancing probiotic viability during intestinal transit and modulating probiotic colonization. In general, research findings suggest that the MFGM holds potential for use as a probiotic carrier to the gut with beneficial health consequences.https://www.mdpi.com/2076-2607/13/2/223milk fat globulesprobioticsbacterial adhesioninteractionshost health |
| spellingShingle | Withanage Prasadini Wasana Mark Waterland David W. Everett Caroline Thum Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host Microorganisms milk fat globules probiotics bacterial adhesion interactions host health |
| title | Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host |
| title_full | Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host |
| title_fullStr | Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host |
| title_full_unstemmed | Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host |
| title_short | Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host |
| title_sort | functional significance of probiotic bacterial interactions with milk fat globules in a human host |
| topic | milk fat globules probiotics bacterial adhesion interactions host health |
| url | https://www.mdpi.com/2076-2607/13/2/223 |
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