Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes
Background: The aim of this study was to evaluate the association between baseline creatine kinase-myocardial band (CK-MB) and the risk of in-hospital all-cause mortality in acute type A and type B aortic dissection (AD) patients, and to explore the predictive value of CK-MB. Methods: A single-cente...
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Elsevier
2025-02-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S235290672400232X |
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| author | Yijing Xin Siqi Lyu Yanmin Yang |
| author_facet | Yijing Xin Siqi Lyu Yanmin Yang |
| author_sort | Yijing Xin |
| collection | DOAJ |
| description | Background: The aim of this study was to evaluate the association between baseline creatine kinase-myocardial band (CK-MB) and the risk of in-hospital all-cause mortality in acute type A and type B aortic dissection (AD) patients, and to explore the predictive value of CK-MB. Methods: A single-center retrospective analysis was performed on 552 acute AD (type A 329 patients, type B 223 patients). Outcomes were the incidence of in-hospital all-cause mortality. Kaplan-Meier curve was used to compare the all-cause death risk in two groups (normal CK-MB group and elevated CK-MB group). The Cox regression model and restricted cubic splines (RCS) were conducted to assess the relationship between CK-MB and outcomes. Stratified analysis was performed based on gender, age (<50 years or ≥ 50 years), and surgery or endovascular therapy. Results: The Kaplan-Meier curves showed statistically significant differences in outcomes among the different CK-MB level groups for both acute type A and type B AD patients. Cox regression analysis revealed that the in-hospital mortality risk was significantly high in the elevated CK-MB groups for both acute type A and type B AD patients. The RCS curve revealed that CK-MB was non-linearly and J-shaped correlated with in-hospital all-cause mortality for acute type A AD patients, and linearly correlated with in-hospital all-cause mortality for acute type B AD patients. Conclusion: Baseline CK-MB elevations were associated with an increased risk of in-hospital all-cause mortality in acute type A and type B AD patients, and it was independently associated with poor prognosis in type A patients. |
| format | Article |
| id | doaj-art-e1913b60e1404e8fa7d709a4118742c4 |
| institution | OA Journals |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-e1913b60e1404e8fa7d709a4118742c42025-08-20T02:15:47ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-02-015610156610.1016/j.ijcha.2024.101566Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomesYijing Xin0Siqi Lyu1Yanmin Yang2Emergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaCorresponding author at: No. 167 Beilishi Road, Xicheng District, 100037 Beijing, People's Republic of China.; Emergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, ChinaBackground: The aim of this study was to evaluate the association between baseline creatine kinase-myocardial band (CK-MB) and the risk of in-hospital all-cause mortality in acute type A and type B aortic dissection (AD) patients, and to explore the predictive value of CK-MB. Methods: A single-center retrospective analysis was performed on 552 acute AD (type A 329 patients, type B 223 patients). Outcomes were the incidence of in-hospital all-cause mortality. Kaplan-Meier curve was used to compare the all-cause death risk in two groups (normal CK-MB group and elevated CK-MB group). The Cox regression model and restricted cubic splines (RCS) were conducted to assess the relationship between CK-MB and outcomes. Stratified analysis was performed based on gender, age (<50 years or ≥ 50 years), and surgery or endovascular therapy. Results: The Kaplan-Meier curves showed statistically significant differences in outcomes among the different CK-MB level groups for both acute type A and type B AD patients. Cox regression analysis revealed that the in-hospital mortality risk was significantly high in the elevated CK-MB groups for both acute type A and type B AD patients. The RCS curve revealed that CK-MB was non-linearly and J-shaped correlated with in-hospital all-cause mortality for acute type A AD patients, and linearly correlated with in-hospital all-cause mortality for acute type B AD patients. Conclusion: Baseline CK-MB elevations were associated with an increased risk of in-hospital all-cause mortality in acute type A and type B AD patients, and it was independently associated with poor prognosis in type A patients.http://www.sciencedirect.com/science/article/pii/S235290672400232XAcute aortic dissectionCreatine kinase-myocardial band (CK-MB)Coronary artery involvementCoronary malperfusionIn-hospital mortality |
| spellingShingle | Yijing Xin Siqi Lyu Yanmin Yang Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes International Journal of Cardiology: Heart & Vasculature Acute aortic dissection Creatine kinase-myocardial band (CK-MB) Coronary artery involvement Coronary malperfusion In-hospital mortality |
| title | Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes |
| title_full | Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes |
| title_fullStr | Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes |
| title_full_unstemmed | Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes |
| title_short | Creatine kinase-MB elevation in patients with acute aortic dissection predict worse in-hospital outcomes |
| title_sort | creatine kinase mb elevation in patients with acute aortic dissection predict worse in hospital outcomes |
| topic | Acute aortic dissection Creatine kinase-myocardial band (CK-MB) Coronary artery involvement Coronary malperfusion In-hospital mortality |
| url | http://www.sciencedirect.com/science/article/pii/S235290672400232X |
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