Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques

Computational drug discovery of potential 5α-reductase phytochemical inhibitors and hair growth promotion using in silico techniques

IntroductionMale pattern hair loss (MPHL), also known as androgenetic alopecia (AGA), is a common disorder primarily caused by dihydrotestosterone (DHT). The Food and Drug Administration (FDA) has approved two 5-alpha reductase (5-AR) inhibitors—finasteride and dutasteride—for treating this conditio...

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Bibliographic Details
Main Authors: Behnam Hasannejad-Asl, Farkhondeh Pooresmaeil, Sareh azadi, Ali Najafi, Ali Esmaeili, Saeid Bagheri-Mohammadi, Bahram Kazemi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioinformatics
Subjects:
androgenetic alopecia
5α-reductase inhibitors
herbal extracts
computational study
hair follicle growth
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1570101/full
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https://www.frontiersin.org/articles/10.3389/fbinf.2025.1570101/full

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