A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL

A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL

Abstract Cutaneous T-cell lymphomas (CTCLs), particularly Mycosis fungoides (MF), frequently exhibit deletions and reduced expression of HNRNPK in CD4 + T cells. To enable in vivo studies, we developed a conditional Hnrnpk knockout mouse that thrives, facilitating the investigation of HNRNPK’s role...

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Bibliographic Details
Main Authors: Yixin Luo, Maarten Vermeer, Margot M. Linssen, Fenna J. de Bie, Marloe Pijnacker-Verspuij, Conny Brouwers, Jill Claassens, Frank R. de Gruijl, Peter Hohenstein, Cornelis P. Tensen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Cutaneous T-cell lymphomas
Mycosis fungoides
CD4 + T cells
HNRNPK
Transgenic mouse
Online Access:https://doi.org/10.1038/s41598-025-98640-6
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