Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR
Abstract INTRODUCTION Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent medial temporal lobe. METHODS U...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70040 |
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| author | Hossein Moein Taghavi Mahta Karimpoor Eric K. vanStaalduinen Christina B. Young Marios Georgiadis Samantha Leventis Mackenzie Carlson America Romero Alexandra Trelle Hillary Vossler Maya Yutsis Jarrett Rosenberg Guido A. Davidzon Greg Zaharchuk Kathleen Poston Anthony D. Wagner Victor W. Henderson Elizabeth Mormino Michael Zeineh |
| author_facet | Hossein Moein Taghavi Mahta Karimpoor Eric K. vanStaalduinen Christina B. Young Marios Georgiadis Samantha Leventis Mackenzie Carlson America Romero Alexandra Trelle Hillary Vossler Maya Yutsis Jarrett Rosenberg Guido A. Davidzon Greg Zaharchuk Kathleen Poston Anthony D. Wagner Victor W. Henderson Elizabeth Mormino Michael Zeineh |
| author_sort | Hossein Moein Taghavi |
| collection | DOAJ |
| description | Abstract INTRODUCTION Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent medial temporal lobe. METHODS Using co‐registered magnetic resonance imaging (MRI) and 18F‐PI‐2620 tau PET‐MR scans in 94 older adults, we computed tau uptake in the piriform‐periamygdaloid cortex, amygdala, entorhinal‐perirhinal cortices, and hippocampus. RESULTS We found an ordinal cross‐sectional increase in piriform cortex tau uptake with increasing disease severity (amyloid‐negative controls, amyloid‐positive controls, mild cognitive impairment [MCI] and AD), comparable to entorhinal‐perirhinal cortex. Amyloid‐positive controls showed significantly greater tau uptake than amyloid‐negative controls. Negative correlations were present between memory performance and piriform uptake. Piriform uptake was not elevated in cognitively unimpaired Parkinson's disease. DISCUSSION Cross‐sectionally, there is an early increase in tau uptake in the piriform cortex in AD but not in Parkinson's disease. Highlights Positron emission tomography–magnetic resonance (PET‐MR) analysis of the piriform cortex sheds light on its role as a potential early region affected by neurodegenerative disorders underlying olfactory dysfunction. Uptake of tau tracer was elevated in the piriform cortex in Alzheimer's disease (AD) and mild cognitive impairment (MCI) but not in Parkinson's disease (PD). Memory performance was worse with greater piriform uptake. |
| format | Article |
| id | doaj-art-df0cc34deaa34af3ac9dd6bf441198a6 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-df0cc34deaa34af3ac9dd6bf441198a62024-12-27T13:08:30ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-10-01164n/an/a10.1002/dad2.70040Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MRHossein Moein Taghavi0Mahta Karimpoor1Eric K. vanStaalduinen2Christina B. Young3Marios Georgiadis4Samantha Leventis5Mackenzie Carlson6America Romero7Alexandra Trelle8Hillary Vossler9Maya Yutsis10Jarrett Rosenberg11Guido A. Davidzon12Greg Zaharchuk13Kathleen Poston14Anthony D. Wagner15Victor W. Henderson16Elizabeth Mormino17Michael Zeineh18Department of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSAWu Tsai Neurosciences InstituteStanford UniversityStanford California USADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of Neurology and Neurological SciencesStanford University School of MedicineStanfordCaliforniaUSADepartment of RadiologyStanford University School of MedicineStanfordCaliforniaUSAAbstract INTRODUCTION Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent medial temporal lobe. METHODS Using co‐registered magnetic resonance imaging (MRI) and 18F‐PI‐2620 tau PET‐MR scans in 94 older adults, we computed tau uptake in the piriform‐periamygdaloid cortex, amygdala, entorhinal‐perirhinal cortices, and hippocampus. RESULTS We found an ordinal cross‐sectional increase in piriform cortex tau uptake with increasing disease severity (amyloid‐negative controls, amyloid‐positive controls, mild cognitive impairment [MCI] and AD), comparable to entorhinal‐perirhinal cortex. Amyloid‐positive controls showed significantly greater tau uptake than amyloid‐negative controls. Negative correlations were present between memory performance and piriform uptake. Piriform uptake was not elevated in cognitively unimpaired Parkinson's disease. DISCUSSION Cross‐sectionally, there is an early increase in tau uptake in the piriform cortex in AD but not in Parkinson's disease. Highlights Positron emission tomography–magnetic resonance (PET‐MR) analysis of the piriform cortex sheds light on its role as a potential early region affected by neurodegenerative disorders underlying olfactory dysfunction. Uptake of tau tracer was elevated in the piriform cortex in Alzheimer's disease (AD) and mild cognitive impairment (MCI) but not in Parkinson's disease (PD). Memory performance was worse with greater piriform uptake.https://doi.org/10.1002/dad2.70040Alzheimer'sMRIolfactionPDPETPET‐MR |
| spellingShingle | Hossein Moein Taghavi Mahta Karimpoor Eric K. vanStaalduinen Christina B. Young Marios Georgiadis Samantha Leventis Mackenzie Carlson America Romero Alexandra Trelle Hillary Vossler Maya Yutsis Jarrett Rosenberg Guido A. Davidzon Greg Zaharchuk Kathleen Poston Anthony D. Wagner Victor W. Henderson Elizabeth Mormino Michael Zeineh Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's MRI olfaction PD PET PET‐MR |
| title | Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR |
| title_full | Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR |
| title_fullStr | Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR |
| title_full_unstemmed | Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR |
| title_short | Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR |
| title_sort | elevated tau in the piriform cortex in alzheimer s but not parkinson s disease using pet mr |
| topic | Alzheimer's MRI olfaction PD PET PET‐MR |
| url | https://doi.org/10.1002/dad2.70040 |
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