A phenome-wide association study of tandem repeat variation in 168,554 individuals from the UK Biobank

Abstract Most genetic association studies focus on binary variants. To identify the effects of multi-allelic variation of tandem repeats (TRs) on human traits, we perform direct TR genotyping and phenome-wide association studies in 168,554 individuals from the UK Biobank, identifying 47 TRs showing...

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Bibliographic Details
Main Authors: Celine A. Manigbas, Bharati Jadhav, Paras Garg, Mariya Shadrina, William Lee, Gabrielle Altman, Alejandro Martin-Trujillo, Andrew J. Sharp
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54678-0
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