Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury
This systematic review focuses on an increasing subset of traumatic brain injury (TBI) survivors who develop post-traumatic parkinsonism (PTP), characterized by slowness of movement (bradykinesia), rigidity (stiffness), postural instability, and resting tremors caused by obstruction or damage to dee...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2024-11-01
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| Series: | Neurotrauma Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/neur.2023.0104 |
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| author | Catherine Rojvirat Gabriel R. Arismendi Erin Feinstein Maynard Guzman Bruce A. Citron Vedad Delic |
| author_facet | Catherine Rojvirat Gabriel R. Arismendi Erin Feinstein Maynard Guzman Bruce A. Citron Vedad Delic |
| author_sort | Catherine Rojvirat |
| collection | DOAJ |
| description | This systematic review focuses on an increasing subset of traumatic brain injury (TBI) survivors who develop post-traumatic parkinsonism (PTP), characterized by slowness of movement (bradykinesia), rigidity (stiffness), postural instability, and resting tremors caused by obstruction or damage to deep brain structures of the basal ganglia. PTP is rare, and one hypothesis to explain PTP rarity is that TBIs severe enough to affect deep brain structures are often lethal; however, with increasing survivability of TBIs, these numbers are expected to increase. The goal of this review is to raise awareness of an expected global increase of a subgroup of TBI patients who are treatment responsive and report therapeutic results aiding providers in diagnosing, educating, and treating PTP patients. Literature over the past 100 years was considered, and 44,663 peer-reviewed articles were identified. Inclusion criteria required a clinical indication of parkinsonian signs and TBI. Twenty-six case reports were ultimately included from which 36 individual patient data points were extracted for this review. Between 1980 and 2010, there has been an increase in reporting of PTP decade after decade. Forty-seven percent of PTP cases have 1–6 months of latency to symptom onset, and 83% of cases were male. PTP can occur with or without presence of brain lesions, and the most common type of injuries that cause PTP are motor vehicle accidents followed by falls. PTP patients are responsive to surgery or medication treatments. Further detail on PTP symptomology, treatment responsiveness, and injury types is provided. |
| format | Article |
| id | doaj-art-dbd6a354c57d489596d2f4ddd856899b |
| institution | DOAJ |
| issn | 2689-288X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj-art-dbd6a354c57d489596d2f4ddd856899b2025-08-20T02:58:58ZengMary Ann LiebertNeurotrauma Reports2689-288X2024-11-0151374910.1089/neur.2023.0104Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain InjuryCatherine Rojvirat0Gabriel R. Arismendi1Erin Feinstein2Maynard Guzman3Bruce A. Citron4Vedad Delic5Laboratory of Molecular Biology, VA New Jersey Health Care System, East Orange, New Jersey, USA.Laboratory of Molecular Biology, VA New Jersey Health Care System, East Orange, New Jersey, USA.Department of Neurology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.Laboratory of Molecular Biology, VA New Jersey Health Care System, East Orange, New Jersey, USA.Laboratory of Molecular Biology, VA New Jersey Health Care System, East Orange, New Jersey, USA.Laboratory of Molecular Biology, VA New Jersey Health Care System, East Orange, New Jersey, USA.This systematic review focuses on an increasing subset of traumatic brain injury (TBI) survivors who develop post-traumatic parkinsonism (PTP), characterized by slowness of movement (bradykinesia), rigidity (stiffness), postural instability, and resting tremors caused by obstruction or damage to deep brain structures of the basal ganglia. PTP is rare, and one hypothesis to explain PTP rarity is that TBIs severe enough to affect deep brain structures are often lethal; however, with increasing survivability of TBIs, these numbers are expected to increase. The goal of this review is to raise awareness of an expected global increase of a subgroup of TBI patients who are treatment responsive and report therapeutic results aiding providers in diagnosing, educating, and treating PTP patients. Literature over the past 100 years was considered, and 44,663 peer-reviewed articles were identified. Inclusion criteria required a clinical indication of parkinsonian signs and TBI. Twenty-six case reports were ultimately included from which 36 individual patient data points were extracted for this review. Between 1980 and 2010, there has been an increase in reporting of PTP decade after decade. Forty-seven percent of PTP cases have 1–6 months of latency to symptom onset, and 83% of cases were male. PTP can occur with or without presence of brain lesions, and the most common type of injuries that cause PTP are motor vehicle accidents followed by falls. PTP patients are responsive to surgery or medication treatments. Further detail on PTP symptomology, treatment responsiveness, and injury types is provided.https://www.liebertpub.com/doi/10.1089/neur.2023.0104basal ganglialoss of consciousnessneurodegenerationparkinsonismtraumatic brain injury |
| spellingShingle | Catherine Rojvirat Gabriel R. Arismendi Erin Feinstein Maynard Guzman Bruce A. Citron Vedad Delic Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury Neurotrauma Reports basal ganglia loss of consciousness neurodegeneration parkinsonism traumatic brain injury |
| title | Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury |
| title_full | Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury |
| title_fullStr | Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury |
| title_full_unstemmed | Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury |
| title_short | Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury |
| title_sort | systematic review of post traumatic parkinsonism an emerging parkinsonian disorder among survivors of traumatic brain injury |
| topic | basal ganglia loss of consciousness neurodegeneration parkinsonism traumatic brain injury |
| url | https://www.liebertpub.com/doi/10.1089/neur.2023.0104 |
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