Uncovering the molecular mechanisms of tonifying kidney and activating blood Decoction against myocardial fibrosis using network Pharmacology and experimental validation

Uncovering the molecular mechanisms of tonifying kidney and activating blood Decoction against myocardial fibrosis using network Pharmacology and experimental validation

Abstract Chronic heart failure(HF) has become a disease of global concern due to its high morbidity and mortality.This has highlighted the need for cardioprotective agents.The Tonifying Kidney and Activating Blood(KTBA) decoction has been approved for clinical treatment of chronic HF.Tanshinone IIA(...

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Bibliographic Details
Main Authors: Rui Xu, Yanping Bi, Yetao Ju, Wenhao Yin, Shujun Zhao, Yan Zhang, Xin Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Chronic heart failure
Cardiac fibrosis
Tonifying kidney and activating blood Decoction
P38MAPK/NF-κB/AQP4 pathway
Network Pharmacology
Online Access:https://doi.org/10.1038/s41598-025-01276-9
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https://doi.org/10.1038/s41598-025-01276-9

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