Serum Tsukushi level is negatively associated with cholesterol efflux capacity in metabolic dysfunction-associated steatotic liver disease: a cross-sectional study

Serum Tsukushi level is negatively associated with cholesterol efflux capacity in metabolic dysfunction-associated steatotic liver disease: a cross-sectional study

Abstract Background Tsukushi (TSK), a recently identified hepatokine, has been shown to affect systemic cholesterol homeostasis and reduce HDL cholesterol (HDL-C) in murine studies. We have investigated whether TSK is associated with HDL-C and HDL function in subjects with and without MASLD. Methods...

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Main Authors: Sum Lam, David T. W. Lui, Carol H. Y. Fong, Ying Wong, Sammy W. M. Shiu, Karen S. L. Lam, Lung-Yi Mak, Man-Fung Yuen, Chi-Ho Lee, Kathryn Choon-Beng Tan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
High density lipoprotein
HDL dysfunction
Reverse cholesterol transport
Dyslipidaemia
Hepatic steatosis
Online Access:https://doi.org/10.1038/s41598-025-06431-w
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