Trimetazidine stimulates intracellular Ca2+ transients and zebrafish locomotor activity in spinal neurons

Abstract The metabolic modulator trimetazidine (TMZ) is an antianginal recently found to improve skeletal muscle performance in mice models of sarcopenia and of amyotrophic lateral sclerosis (ALS). The mechanism underlying the effect of TMZ on locomotor activity has been proposed to rely on its abil...

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Bibliographic Details
Main Authors: Sara Bernardi, Sara Vitolo, Chiara Gabellini, Maria Marchese, Elisabetta Ferraro
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-06065-y
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