Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice

Inter-Relationship Between Melanoma Vemurafenib Tolerance Thresholds and Metabolic Pathway Choice

Melanomas quickly acquire resistance to vemurafenib, an important therapeutic for BRAFV600 mutant melanomas. Although combating vemurafenib resistance (VemR) to counter mitochondrial metabolic shift using mitochondria-targeting therapies has promise, no studies have analyzed the relationship between...

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Bibliographic Details
Main Authors: Pratima Nangia-Makker, Madison Ahrens, Neeraja Purandare, Siddhesh Aras, Jing Li, Katherine Gurdziel, Hyejeong Jang, Seongho Kim, Malathy P Shekhar
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
melanoma
BRAF
adaptive resistance
RNA-seq
metabolome
Wnt signaling
Online Access:https://www.mdpi.com/2073-4409/14/12/923
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