Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death
Sertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger cholesterol accumulation within lysosomes followed by lysosomal m...
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| Main Authors: | Karla Alvarez-Valadez, Jonathan G. Pol, Guido Kroemer, Mojgan Djavaheri-Mergny |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2531113 |
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