Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma

Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma

IntroductionThe development of high-throughput sequencing technologies and targeted therapeutic strategies has significantly improved the prognosis of lung adenocarcinoma (LUAD) patients with sensitive gene mutations. However, patients harboring rare or no actionable mutations were rarely benefit fr...

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Main Authors: Ke Ma, Jie Xu, Congyue Wang, Xu Cao, Wenjie Yu, Jingjing Xi, Xuan Zhang, Jiamin Zhan, Yang Liu, Aoyang Yu, Shuhan Liu, Yanhua Liu, Chong Chen, Xiaoli Mai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
single-cell RNA sequencing
lung adenocarcinoma
multi-omics
prognostic signature
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1590216/full
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