Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology
Conclusion: The study highlighted a significant association between prostate cancer occurrence, glutathione metabolism, and monocyte activity. The critical interplay between glutathione metabolism and immune cell dynamics in prostate cancer is underscored, proposing novel biomarkers for early diagno...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/ijcp/9943789 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187654201606144 |
|---|---|
| author | Dongdong Wang Mingwei Zhan Pengfei Liu Yi Yu Rijian Guan |
| author_facet | Dongdong Wang Mingwei Zhan Pengfei Liu Yi Yu Rijian Guan |
| author_sort | Dongdong Wang |
| collection | DOAJ |
| description | Conclusion: The study highlighted a significant association between prostate cancer occurrence, glutathione metabolism, and monocyte activity. The critical interplay between glutathione metabolism and immune cell dynamics in prostate cancer is underscored, proposing novel biomarkers for early diagnosis and potential therapeutic targets. Notably, ATP6V1G1 emerged as a key gene with significant diagnostic and prognostic value, offering new prospects for therapeutic intervention in prostate cancer. |
| format | Article |
| id | doaj-art-cce836ced0104123beddfd489845e3bb |
| institution | OA Journals |
| issn | 1742-1241 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj-art-cce836ced0104123beddfd489845e3bb2025-08-20T02:16:03ZengWileyInternational Journal of Clinical Practice1742-12412025-01-01202510.1155/ijcp/9943789Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer EtiologyDongdong Wang0Mingwei Zhan1Pengfei Liu2Yi Yu3Rijian Guan4Department of PharmacyDepartment of UrologyDepartment of UrologyDepartment of Reproductive MedicineDepartment of UrologyConclusion: The study highlighted a significant association between prostate cancer occurrence, glutathione metabolism, and monocyte activity. The critical interplay between glutathione metabolism and immune cell dynamics in prostate cancer is underscored, proposing novel biomarkers for early diagnosis and potential therapeutic targets. Notably, ATP6V1G1 emerged as a key gene with significant diagnostic and prognostic value, offering new prospects for therapeutic intervention in prostate cancer.http://dx.doi.org/10.1155/ijcp/9943789 |
| spellingShingle | Dongdong Wang Mingwei Zhan Pengfei Liu Yi Yu Rijian Guan Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology International Journal of Clinical Practice |
| title | Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology |
| title_full | Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology |
| title_fullStr | Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology |
| title_full_unstemmed | Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology |
| title_short | Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology |
| title_sort | integrative mendelian randomization and transcriptome analysis unveil dual pathways in prostate cancer etiology |
| url | http://dx.doi.org/10.1155/ijcp/9943789 |
| work_keys_str_mv | AT dongdongwang integrativemendelianrandomizationandtranscriptomeanalysisunveildualpathwaysinprostatecanceretiology AT mingweizhan integrativemendelianrandomizationandtranscriptomeanalysisunveildualpathwaysinprostatecanceretiology AT pengfeiliu integrativemendelianrandomizationandtranscriptomeanalysisunveildualpathwaysinprostatecanceretiology AT yiyu integrativemendelianrandomizationandtranscriptomeanalysisunveildualpathwaysinprostatecanceretiology AT rijianguan integrativemendelianrandomizationandtranscriptomeanalysisunveildualpathwaysinprostatecanceretiology |