Tyrosine kinase as therapeutic target of neurodegenerative disorders
Classes of hereditary and sporadic illnesses known as neurodegenerative diseases are linked to gradual nervous system malfunction and neuronal death. Protein kinases are an increasingly popular class of pharmacological targets for disorders affecting peripheral tissues; nevertheless, developing kina...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000137 |
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| author | Dipanjan Karati Dileep Kumar |
| author_facet | Dipanjan Karati Dileep Kumar |
| author_sort | Dipanjan Karati |
| collection | DOAJ |
| description | Classes of hereditary and sporadic illnesses known as neurodegenerative diseases are linked to gradual nervous system malfunction and neuronal death. Protein kinases are an increasingly popular class of pharmacological targets for disorders affecting peripheral tissues; nevertheless, developing kinase-targeted therapies for diseases affecting the central nervous system (CNS) is still difficult, mostly because of problems related to CNS drug discovery. A class of membrane-bound receptors known as receptor tyrosine kinases (RTKs) consists of an intracellular catalytic domain, a transmembrane domain, and an extracellular ligand-binding domain. RTKs are essential for many diverse biological functions, such as motility, growth, differentiation, and metabolism. The deregulation of RTK activity aids the development of several neurodegenerative diseases. The research found that in neurological diseases, changes were made to the vascular endothelial growth factor-B TAM receptors, tropomyosin receptor kinase, and epidermal growth factor receptor 1. Furthermore, it is shown that two important routes for neurite expansion and neuronal survival triggered by RTKs are the Wnt/catenin and PI3K/Akt/GSK-3β signaling pathways. PTKs, such as non-receptor tyrosine kinases, are also important for neuronal function and the development of neurodegeneration. When aberrantly produced or activated, non-receptor tyrosine kinase (Abelson kinase) c-Abl seems to have a role in both the normal development of brain tissue and the emergence of neurodegenerative diseases. The function of both RTKs and PTKs in neurodegenerative illnesses is described in this study, with special attention to their signaling pathways and prospects for treatment. |
| format | Article |
| id | doaj-art-ca9f184cfa8c4cfb8c83ca0b51a0a4a9 |
| institution | DOAJ |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-ca9f184cfa8c4cfb8c83ca0b51a0a4a92025-08-20T02:50:29ZengElsevierBrain Disorders2666-45932025-03-011710019310.1016/j.dscb.2025.100193Tyrosine kinase as therapeutic target of neurodegenerative disordersDipanjan Karati0Dileep Kumar1Department of Pharmaceutical Technology, School of Pharmacy, Techno India University, Kolkata 900017 West Bengal, IndiaDepartment of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India; Corresponding author at: Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.Classes of hereditary and sporadic illnesses known as neurodegenerative diseases are linked to gradual nervous system malfunction and neuronal death. Protein kinases are an increasingly popular class of pharmacological targets for disorders affecting peripheral tissues; nevertheless, developing kinase-targeted therapies for diseases affecting the central nervous system (CNS) is still difficult, mostly because of problems related to CNS drug discovery. A class of membrane-bound receptors known as receptor tyrosine kinases (RTKs) consists of an intracellular catalytic domain, a transmembrane domain, and an extracellular ligand-binding domain. RTKs are essential for many diverse biological functions, such as motility, growth, differentiation, and metabolism. The deregulation of RTK activity aids the development of several neurodegenerative diseases. The research found that in neurological diseases, changes were made to the vascular endothelial growth factor-B TAM receptors, tropomyosin receptor kinase, and epidermal growth factor receptor 1. Furthermore, it is shown that two important routes for neurite expansion and neuronal survival triggered by RTKs are the Wnt/catenin and PI3K/Akt/GSK-3β signaling pathways. PTKs, such as non-receptor tyrosine kinases, are also important for neuronal function and the development of neurodegeneration. When aberrantly produced or activated, non-receptor tyrosine kinase (Abelson kinase) c-Abl seems to have a role in both the normal development of brain tissue and the emergence of neurodegenerative diseases. The function of both RTKs and PTKs in neurodegenerative illnesses is described in this study, with special attention to their signaling pathways and prospects for treatment.http://www.sciencedirect.com/science/article/pii/S2666459325000137Tyrosine kinaseNeurodegenerative disordersPyk2Ron receptorParkin-Beclin-1 |
| spellingShingle | Dipanjan Karati Dileep Kumar Tyrosine kinase as therapeutic target of neurodegenerative disorders Brain Disorders Tyrosine kinase Neurodegenerative disorders Pyk2 Ron receptor Parkin-Beclin-1 |
| title | Tyrosine kinase as therapeutic target of neurodegenerative disorders |
| title_full | Tyrosine kinase as therapeutic target of neurodegenerative disorders |
| title_fullStr | Tyrosine kinase as therapeutic target of neurodegenerative disorders |
| title_full_unstemmed | Tyrosine kinase as therapeutic target of neurodegenerative disorders |
| title_short | Tyrosine kinase as therapeutic target of neurodegenerative disorders |
| title_sort | tyrosine kinase as therapeutic target of neurodegenerative disorders |
| topic | Tyrosine kinase Neurodegenerative disorders Pyk2 Ron receptor Parkin-Beclin-1 |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000137 |
| work_keys_str_mv | AT dipanjankarati tyrosinekinaseastherapeutictargetofneurodegenerativedisorders AT dileepkumar tyrosinekinaseastherapeutictargetofneurodegenerativedisorders |