Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis to cause alzheimer’s disease-like pathology and cognitive decline

Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis to cause alzheimer’s disease-like pathology and cognitive decline

Abstract Background Periodontitis is a risk factor linked to Alzheimer’s disease (AD), and characterized by amyloid-beta (Aβ) pathology. Mounting evidence suggests a contributory role of periodontitis in the onset and progression of AD. Type I interferons are upregulated in Porphyromonas gingivalis...

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Bibliographic Details
Main Authors: Lingwenyao Kong, Juanjuan Li, Lu Gao, Yonggang Zhao, Weixian Chen, Xumeng Wang, Songlin Wang, Fu Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Periodontitis
Innate immunity
Neuroinflammation
IFITM3
Cognitive decline
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13195-025-01818-3
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