The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor

The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor

Abstract Background Transcription factor 4 (TCF4) is a member of the basic helix-loop-helix (bHLH) family of transcription factors that guides proper embryogenesis, particularly neurogenesis, myogenesis, heart development and hematopoiesis. The interaction of TCF4 with DNA is dependent on the presen...

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Main Authors:	Nikola Sozańska, Barbara P. Klepka, Anna Niedzwiecka, Lilia Zhukova, Michał Dadlez, Beata Greb-Markiewicz, Andrzej Ożyhar, Aneta Tarczewska
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Series:	Cell Communication and Signaling
Subjects:	Transcription factor 4 (TCF4) Immunoglobulin transcription factor 2 (ITF2) SL3-3 enhancer factor 2 (SEF2) Basic helix-loop-helix (bHLH) Intrinsically disordered regions (IDRs) Intrinsically disordered proteins (IDPs)
Online Access:	https://doi.org/10.1186/s12964-025-02154-7
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