Downregulation of UDP-glucose 6-dehydrogenase predicts adverse outcomes in patients with colorectal cancer and promotes tumorigenesis

Downregulation of UDP-glucose 6-dehydrogenase predicts adverse outcomes in patients with colorectal cancer and promotes tumorigenesis

Abstract UDP-glucose 6-dehydrogenase (UGDH) is the key enzyme of glucuronic acid metabolism and a key mediator in several cancer developmental signaling pathways. However, the expression and function of UGDH in colorectal cancer (CRC) are unclear. Bioinformatics analysis was conducted to research th...

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Bibliographic Details
Main Authors: Mengyuan Wang, Zhiming Ge, Xianxian Fan, Hongbo Zhao, Zhenfu Shi, Jiucun Zhang, Li Jin, Yan Li, Jie Wang, Xiaobin Zao, Yun Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
UDP-glucose 6-dehydrogenase
Colorectal cancer
Prognostic marker
Bioinformatics
p53 signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-07889-4
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