Sigesbeckia pubescens makino alleviates ulcerative colitis in mice by modulating the Nrf2/Keap1 pathway

Sigesbeckia pubescens makino alleviates ulcerative colitis in mice by modulating the Nrf2/Keap1 pathway

BackgroundUlcerative colitis (UC) is a prevalent immune-mediated inflammatory bowel disease characterized by mucus secretion, hematochezia, and diarrhea. This study compared the therapeutic effects of three Siegesbeckiae Herba (SH) species used in traditional Chinese medicine—Sigesbeckia orientalis...

Full description

Saved in:

Bibliographic Details
Main Authors:	Qiu-Shuo Ma, Qi-Ling Chen, Guo-Ping Wu, Ya-Wen Yao, Yu-Xin Fan, Ke-Gang Linghu, Jun-Ming Chen, Wei Xiong, Hua Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	ulcerative colitis siegesbeckiae herba Sigesbeckia pubescens makino antioxidant Nrf2
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1588525/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Inhibition of the invasive plant Ambrosia trifida by Sigesbeckia glabrescens extracts
by: Lijuan Yin, et al.
Published: (2025-01-01)

Characteristics and phylogenetic analysis of the complete chloroplast genome of Gardneria multiflora Makino 1901 from the family Loganiaceae
by: Guangyan Li, et al.
Published: (2025-09-01)

EFEK PEMBERIAN EKSTRAK DAUN CARICA PUBESCENS TERHADAP JUMLAH NEUTROFIL PADA TIKUS SPRAGUE DAWLEY YANG DIINDUKSI AZOXYMETHANE
by: Faradilla Nadya Blezeinsky, et al.
Published: (2019-08-01)

Drying Shrinkage and Mechanical Strength of Cementitious Composites with Alkali-Treated Makino Bamboo Fibers
by: Chin-Hao Yeh, et al.
Published: (2024-12-01)

The protective effect of naringenin on ulcerative colitis in mice through increasing Nrf2 pathway activity
by: Li Jiaxiang, et al.
Published: (2025-03-01)

Development of In Vitro Conservation Medium of Carica pubescens Lenne & K. Koch through Nutrients Concentration Reduction and Osmoregulator Addition
by: Enni Suwarsi Rahayu, et al.
Published: (2015-03-01)

A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of <i>Viola yedoensis</i> Makino
by: Shuang Wang, et al.
Published: (2025-04-01)

Integrative transcriptomic-physiological analysis deciphers nitrogen-mediated carbon reallocation balancing growth and flavonoid metabolism in Epimedium pubescens
by: Shangnian Liu, et al.
Published: (2025-05-01)

EFEK PEMBERIAN EKSTRAK DAUN Carica pubescens TERHADAP JUMLAH LEUKOSIT PADA TIKUS Sprague Dawley YANG DIINDUKSI AZOXYMETHANE : STUDI DI LABORATORIUM PENELITIAN DAN PENGUJIAN TERPADU 4 UNIVERSITAS GADJAH MADA
by: Eka Meyliana Sugeng, et al.
Published: (2019-02-01)

Antiplatelet and antithrombotic effect of Phyllostachys pubescens leaves and Mume Fructus combination
by: Wen Yi Jin, et al.
Published: (2013-06-01)

Temporal dynamics of medium and micronutrient requirements in Epimedium pubescens: key elements regulating growth and Icariin-Flavonoids biosynthesis
by: Xiaojing An, et al.
Published: (2025-04-01)

Partial sequence analysis and relative expression of the HSP70 gene of Vasconcellea pubescens
by: Fabio Marcelo Idrovo Espín, et al.
Published: (2023-09-01)

EFEK PEMBERIAN EKSTRAK DAUN Carica pubescens TERHADAP JUMLAH LIMFOSIT TIKUS Sprague dawley YANG DIINDUKSI AZOXYMETHANE : STUDI DI LABORATORIUM PENELITIAN DAN PENGUJIAN TERPADU 4 UNIVERSITAS GADJAH MADA
by: Maharani Shofa Yudina, et al.
Published: (2019-02-01)

Genome-wide identification and expression patterns of the aspartic protease gene family in Epimedium pubescens
by: Huifang Zheng, et al.
Published: (2025-05-01)

Effect of Premna pubescens Ethanol Extract on Erythrocyte Count and Kidney Histology in Rattus norvegicus L
by: Srinatalia Silaen
Published: (2025-01-01)

Coptis japonica Makino ethanol extracts attenuates cancer cachexia induced muscle and fat wasting through inhibition of the STAT3 signaling pathway
by: Yo Sep Hwang, et al.
Published: (2025-05-01)

Antioxidant Potential and In Vitro Antidiabetic Activity of <i>Paeonia japonica</i> (Makino) Miyabe & Takeda Extract and Its Isolated Compounds
by: Jinfeng Yang, et al.
Published: (2024-11-01)

Chilean Papaya (<i>Vasconcellea pubescens</i>): A Native Fruit with a High Health-Promoting Functional Potential
by: Roberto Lemus-Mondaca, et al.
Published: (2024-12-01)

Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway
by: Teerapap Panklai, et al.
Published: (2025-02-01)

Research progress on the role of Nrf2-Keap1 signaling pathway in acute kidney injury
by: HUANG Xi-jie, et al.
Published: (2019-01-01)

Optimization of In Vitro Conservation Protocol of Carica pubescens Lenne & K. Koch through Medium Concentration, Temperature and Irradiation Duration Decrease
by: Enni Suwarsi Rahayu, et al.
Published: (2016-03-01)

Optimasi Jenis dan Konsentrasi ZPT dalam Induksi Kalus Embriogenik dan Regenerasi menjadi Planlet pada Carica pubescens (Lenne & K.Koch)
by: Nika Sari, et al.
Published: (2014-03-01)

Three New Physalins from <i>Physalis Alkekengi</i> L. var. <i>franchetii</i> (Mast.) Makino
by: Ji Zhao, et al.
Published: (2025-07-01)

Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration, and gut microbiota modulation
by: Sheng Li, et al.
Published: (2025-07-01)

In Vitro Shoot Regeneration and Multiplication of Peruvian Rocoto Chili Pepper (<i>Capsicum pubescens</i> Ruiz & Pav.)
by: Angel David Hernández-Amasifuen, et al.
Published: (2024-10-01)

Extracts from <i>Allium pseudojaponicum Makino</i> Target STAT3 Signaling Pathway to Overcome Cisplatin Resistance in Lung Cancer
by: Soo-Bin Nam, et al.
Published: (2025-04-01)

Cloning and sequence analysis of a specific amplified fragment related to genic male sterility AB lines of Chinese cabbage (Brassica campestris L. ssp. chinensis Makino)
by: FU Qing-gong, et al.
Published: (2004-09-01)

Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway
by: Wang Y, et al.
Published: (2025-01-01)

KEAP1–NRF2 system regulates age‐related spermatogenesis dysfunction
by: Sohei Kuribayashi, et al.
Published: (2024-01-01)

Primer registro de Chiococca motleyana (Rubiaceae) para los bosques tropicales caducifolios de la Depresión Central de Chiapas, México
by: Luis Humberto Vicente Rivera, et al.
Published: (2018-10-01)

Isolation and expression analysis of anther-specific gene BcPRO from Brassica campestris ssp. chinensis(L.) Makino
by: JIANG Ming, et al.
Published: (2008-01-01)

The role of the KEAP1-NRF2 signaling pathway in form deprivation myopia guinea pigs
by: Zhiming Gu, et al.
Published: (2024-11-01)

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis
by: Giovanni Tossetta, et al.
Published: (2024-10-01)

KEAP1‐NRF2/HO‐1 Pathway Promotes Ferroptosis and Neuronal Injury in Schizophrenia
by: Feng Zhu, et al.
Published: (2025-03-01)

Mechanisms of Keap1/Nrf2 modulation in bacterial infections: implications in persistence and clearance
by: Marco Antonio Romero-Durán, et al.
Published: (2024-12-01)

Transcriptomic Characterization Reveals Mitochondrial Involvement in Nrf2/Keap1-Mediated Osteoclastogenesis
by: Eiko Sakai, et al.
Published: (2024-12-01)

Wuda Granule Alleviates DSS-Induced Colitis in Mice by Inhibiting Inflammation, Protecting Intestinal Barrier and Reducing Oxidative Stress Through Nrf2/Keap1/HO-1 Pathway
by: Wang T, et al.
Published: (2025-06-01)

Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway
by: Huafang Jia, et al.
Published: (2025-04-01)

Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors
by: Yi Sun, et al.
Published: (2025-05-01)

Oxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats
by: Juan Tang, et al.
Published: (2024-11-01)