Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias

Role of glial cells in motor neuron degeneration in hereditary spastic paraplegias

This review provides a comprehensive overview of hereditary spastic paraplegias (HSPs) and summarizes the recent progress on the role of glial cells in the pathogenesis of HSPs. HSPs are a heterogeneous group of neurogenetic diseases characterized by axonal degeneration of cortical motor neurons, le...

Full description

Saved in:

Bibliographic Details
Main Authors:	Manaswini Vijayaraghavan, Sarvika Periyapalayam Murali, Gitika Thakur, Xue-Jun Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	axonal degeneration motor neurons astrocytes microglia lipid dysfunction neuroinflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1553658/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection
by: Chaoqiang Guan, et al.
Published: (2025-06-01)

The dual nature of neuroinflammation in networked brain
by: Ludmila Müller, et al.
Published: (2025-08-01)

Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective
by: Jia-Jun Ju, et al.
Published: (2025-01-01)

Neuroimmune crosstalk in chronic neuroinflammation: microglial interactions and immune modulation
by: Ludmila Müller, et al.
Published: (2025-04-01)

SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant
by: Franca Orsini, et al.
Published: (2024-12-01)

Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
by: Paulo Victor Sgobbi de Souza, et al.

Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders
by: Mi Eun Kim, et al.
Published: (2024-12-01)

Mitochondrial damage-associated molecular patterns: Neuroimmunomodulators in central nervous system pathophysiology
by: Noah A. H. Brooks, et al.
Published: (2026-04-01)

Astrocyte–microglia crosstalk in subarachnoid hemorrhage: mechanisms and treatments
by: Kaibo Yu, et al.
Published: (2025-06-01)

Neuroinflammation and stress-induced pathophysiology in major depressive disorder: mechanisms and therapeutic implications
by: Kunying Zhao, et al.
Published: (2025-04-01)

Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease
by: Jenna L. Gollihue, et al.
Published: (2025-08-01)

Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV
by: Sarah J. Byrnes, et al.
Published: (2025-05-01)

The role of astrocytes from synaptic to non-synaptic plasticity
by: Rafael Sanz-Gálvez, et al.
Published: (2024-10-01)

Neuroinflammation and energy metabolism: a dual perspective on ischemic stroke
by: Wen Lei, et al.
Published: (2025-04-01)

Tryptophan Metabolism Through the Kynurenine Pathway in Glial Cells
by: Deivison Silva Argolo, et al.
Published: (2025-03-01)

Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders
by: Ángel R. Rábago-Monzón, et al.
Published: (2025-05-01)

Bacterial lipopolysaccharide model of neuroinflammation-associated neurodegeneration in Wistar rats: A comparison between different durations of lipopolysaccharide induction
by: Vandana Blossom, et al.
Published: (2024-11-01)

Modulation of the central nervous system immune response and neuroinflammation via Wnt signaling in health and neurodegenerative diseases
by: Kevin Fang
Published: (2024-12-01)

Hippocampal neuroinflammation and neuronal injury in the acute phase of pentylenetetrazol induced epilepsy mouse model
by: Linyu ZHI, et al.
Published: (2025-04-01)

Hereditary spastic paraplegias
by: R. F. Kutlubaeva, et al.
Published: (2024-01-01)

Axonal degeneration in association with carpal tunnel syndrome
by: Marcelo Ribeiro Caetano
Published: (2003-03-01)

Multitarget Effects of Nrf2 Signalling in the Brain: Common and Specific Functions in Different Cell Types
by: Elisa Navarro, et al.
Published: (2024-12-01)

Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review
by: Andreea Sălcudean, et al.
Published: (2025-03-01)

Crosstalk between neuroinflammation and ferroptosis: Implications for Parkinson’s disease progression
by: Xiangyu Guo, et al.
Published: (2025-03-01)

The roles of microglia and astrocytes in neuroinflammation of Alzheimer’s disease
by: Jialin Han, et al.
Published: (2025-05-01)

Old Age Exacerbates White Matter Neuroinflammation and Cognitive Deficits Following Closed-Head Injury, Particularly in Female Mice
by: Teresa Macheda, et al.
Published: (2024-11-01)

Astrocyte-induced synchronization of neural network activity
by: Ermolaeva, Anastasia Viktorovna, et al.
Published: (2025-03-01)

Bridging regional neurovascular unit heterogeneity and cognitive function: a review
by: Amalia Tsintzou, et al.
Published: (2025-08-01)

Unravelling axonal transcriptional landscapes: insights from induced pluripotent stem cell-derived cortical neurons and implications for motor neuron degeneration
by: Jishu Xu, et al.
Published: (2025-06-01)

Corrigendum: Boosting antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in parkinsonian brain via an Nrf2-driven Wnt/β-catenin prosurvival axis
by: Maria Francesca Serapide, et al.
Published: (2025-04-01)

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology
by: Pankaj Gaur, et al.
Published: (2025-04-01)

The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer’s disease
by: Xueyan Liu, et al.
Published: (2025-11-01)

The SAP130/Mincle axis was involved in sevoflurane-induced neuronal death and microglial activation in juvenile mice
by: Zi-Heng Zhou, et al.
Published: (2025-07-01)

Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction
by: Yue Hu, et al.
Published: (2024-12-01)

Adolescent binge alcohol exposure accelerates Alzheimer’s disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling
by: Rachael P. Fisher, et al.
Published: (2025-02-01)

Glial cell crosstalk in the local microenvironment following spinal cord injury
by: Erliang Li, et al.
Published: (2025-09-01)

Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders
by: Yaping Chu, et al.
Published: (2025-08-01)

Movement disorders in hereditary spastic paraplegias
by: Jose Luiz Pedroso, et al.
Published: (2023-11-01)

Wallerian degeneration: From mechanism to disease to imaging
by: Ruiqi Tian, et al.
Published: (2025-01-01)

METABOLIC REPROGRAMMING OF MICROGLIA AND ASTROCYTES AS A FACTOR IN THE REGULATION OF NEUROINFLAMMATION IN ISCHEMIC STROKE
by: Mikhail Bobrov, et al.
Published: (2019-08-01)