Galangin alleviates alcoholic liver disease by regulating the gut-liver axis
The imbalance of gut microbiota ecology caused by alcohol consumption disrupts the gut-liver axis, leading to the occurrence and progression of alcoholic liver disease (ALD). This study investigates the effects of galangin (GA) on the gut-liver axis in an alcohol-induced mouse model of ALD, focusing...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624005085 |
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| author | Dongzhu Duan Zhenzhen Du Ling Zhao |
| author_facet | Dongzhu Duan Zhenzhen Du Ling Zhao |
| author_sort | Dongzhu Duan |
| collection | DOAJ |
| description | The imbalance of gut microbiota ecology caused by alcohol consumption disrupts the gut-liver axis, leading to the occurrence and progression of alcoholic liver disease (ALD). This study investigates the effects of galangin (GA) on the gut-liver axis in an alcohol-induced mouse model of ALD, focusing on its potential to regulate gut microbiota composition, intestinal permeability, and hepatic inflammation. The results showed that GA intervention alleviated liver oxidative stress injury and inflammation, improved gut microbiota imbalance, regulated intestinal permeability by up-regulating the expression of tight junction proteins, and enhanced intestinal barrier function. GA treatment reduced liver oxidative stress and inflammation rectified, alcohol-induced dysbiosis, and bolstered the intestinal barrier by up-regulating tight junction proteins. Additionally, the improvement of ALD by GA is mainly related to the Metabolism of xenobiotics by cytochrome P450 and Glutathione metabolism pathways. These results suggest that GA may alleviate ALD by regulating abnormalities of the gut-liver axis. |
| format | Article |
| id | doaj-art-c403cd71b0f448599282fe659422c668 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-c403cd71b0f448599282fe659422c6682024-11-16T05:10:43ZengElsevierJournal of Functional Foods1756-46462024-11-01122106506Galangin alleviates alcoholic liver disease by regulating the gut-liver axisDongzhu Duan0Zhenzhen Du1Ling Zhao2School of Life Science and Technology, Wuhan Polytechnic University, 430023 Wuhan, PR ChinaSchool of Life Science and Technology, Wuhan Polytechnic University, 430023 Wuhan, PR ChinaCorresponding author.; School of Life Science and Technology, Wuhan Polytechnic University, 430023 Wuhan, PR ChinaThe imbalance of gut microbiota ecology caused by alcohol consumption disrupts the gut-liver axis, leading to the occurrence and progression of alcoholic liver disease (ALD). This study investigates the effects of galangin (GA) on the gut-liver axis in an alcohol-induced mouse model of ALD, focusing on its potential to regulate gut microbiota composition, intestinal permeability, and hepatic inflammation. The results showed that GA intervention alleviated liver oxidative stress injury and inflammation, improved gut microbiota imbalance, regulated intestinal permeability by up-regulating the expression of tight junction proteins, and enhanced intestinal barrier function. GA treatment reduced liver oxidative stress and inflammation rectified, alcohol-induced dysbiosis, and bolstered the intestinal barrier by up-regulating tight junction proteins. Additionally, the improvement of ALD by GA is mainly related to the Metabolism of xenobiotics by cytochrome P450 and Glutathione metabolism pathways. These results suggest that GA may alleviate ALD by regulating abnormalities of the gut-liver axis.http://www.sciencedirect.com/science/article/pii/S1756464624005085GalanginAlcoholic liver diseaseGut-liver axisGut microbiotaTranscriptome |
| spellingShingle | Dongzhu Duan Zhenzhen Du Ling Zhao Galangin alleviates alcoholic liver disease by regulating the gut-liver axis Journal of Functional Foods Galangin Alcoholic liver disease Gut-liver axis Gut microbiota Transcriptome |
| title | Galangin alleviates alcoholic liver disease by regulating the gut-liver axis |
| title_full | Galangin alleviates alcoholic liver disease by regulating the gut-liver axis |
| title_fullStr | Galangin alleviates alcoholic liver disease by regulating the gut-liver axis |
| title_full_unstemmed | Galangin alleviates alcoholic liver disease by regulating the gut-liver axis |
| title_short | Galangin alleviates alcoholic liver disease by regulating the gut-liver axis |
| title_sort | galangin alleviates alcoholic liver disease by regulating the gut liver axis |
| topic | Galangin Alcoholic liver disease Gut-liver axis Gut microbiota Transcriptome |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624005085 |
| work_keys_str_mv | AT dongzhuduan galanginalleviatesalcoholicliverdiseasebyregulatingthegutliveraxis AT zhenzhendu galanginalleviatesalcoholicliverdiseasebyregulatingthegutliveraxis AT lingzhao galanginalleviatesalcoholicliverdiseasebyregulatingthegutliveraxis |