Effect of sibutramine on intraocular pressure
Objective: This study evaluated the effects of sibutramine on intraocular pressure (IOP) and body-mass index (BMI). Methods: Thirty obese females (body-mass index >30 kg/m2) treated with sibutramine (10 mg/day) plus diet restriction for 3 months were included in the study. IOP, BMI, and blood...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Philippine Academy of Ophthalmology
2006-06-01
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| Series: | Philippine Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://paojournal.com/index.php/pjo/article/view/369 |
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| Summary: | Objective: This study evaluated the effects of sibutramine on intraocular pressure (IOP) and body-mass index (BMI).
Methods: Thirty obese females (body-mass index >30 kg/m2) treated with sibutramine (10 mg/day) plus diet restriction for 3 months were included in the study. IOP, BMI, and blood biochemical parameters were measured at the beginning and end of the treatment. Results were evaluated statistically by paired t-test, analysis of variance, and least-significant difference test.
Results: A statistically significant decrease was observed in the mean body-mass index (p < 0.001) and serum triglyceride (p < 0.001), while a statistically insignificant increase was observed in IOP (p = 0.54).
Conclusion: While sibutramine provided an effective means for weight loss, it caused a slight increase in IOP, although this was not statistically significant. Nevertheless, it is prudent to monitor IOP in selected obese patients treated with sibutramine. |
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| ISSN: | 0031-7659 |