Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020
Abstract Background The Cardiometabolic Index (CMI), a composite marker integrating lipid profiles (triglycerides-to-HDL-C ratio) and abdominal obesity (waist-to-height ratio), we aimed to assess its association with gallstone prevalence. Methods We analyzed data from 2,692 participants in the NHANE...
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BMC
2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03777-3 |
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| author | Huachao Zheng Bo Wu Caixiang Zhuang Jiesheng Mao Min li Yuncheng Luo Lidong Huang Sisi Lin Feiyang Zhao Yiren Hu |
| author_facet | Huachao Zheng Bo Wu Caixiang Zhuang Jiesheng Mao Min li Yuncheng Luo Lidong Huang Sisi Lin Feiyang Zhao Yiren Hu |
| author_sort | Huachao Zheng |
| collection | DOAJ |
| description | Abstract Background The Cardiometabolic Index (CMI), a composite marker integrating lipid profiles (triglycerides-to-HDL-C ratio) and abdominal obesity (waist-to-height ratio), we aimed to assess its association with gallstone prevalence. Methods We analyzed data from 2,692 participants in the NHANES 2017–2020 dataset. Gallstones were identified through self-reported data, which may introduce bias in the diagnosis. This limitation should be considered when interpreting the results. Logistic regression modelling, smoothed curve fitting and threshold effect analysis assessed the association between CMI and gallstones. Result Higher CMI was significantly associated with an increased risk of gallstones (OR = 1.90, 95% CI: 1.37–2.62, P < 0.0001). A threshold effect was observed at CMI = 0.85, below which risk increased significantly (OR = 2.62, 95% CI:1.34–5.12, P = 0.0049), but became non-significant above this value. The association was stronger in women. Conclusion Our findings support the use of CMI as a potential predictive marker for gallstone risk, suggesting its integration into clinical assessments for early detection and prevention. |
| format | Article |
| id | doaj-art-be88438b923e4a4fb1e8a2efee7e16a5 |
| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-be88438b923e4a4fb1e8a2efee7e16a52025-08-20T03:04:50ZengBMCBMC Gastroenterology1471-230X2025-04-0125111010.1186/s12876-025-03777-3Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020Huachao Zheng0Bo Wu1Caixiang Zhuang2Jiesheng Mao3Min li4Yuncheng Luo5Lidong Huang6Sisi Lin7Feiyang Zhao8Yiren Hu9Department of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of Neurology, Postgraduate Training Base Alliance of Wenzhou Medical University (WenzhouPeople’s Hospital)Department of Neurology, Postgraduate Training Base Alliance of Wenzhou Medical University (WenzhouPeople’s Hospital)Department of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalDepartment of General Surgery, The Third Clinical College of Wenzhou Medical University, Wenzhou People’s HospitalAbstract Background The Cardiometabolic Index (CMI), a composite marker integrating lipid profiles (triglycerides-to-HDL-C ratio) and abdominal obesity (waist-to-height ratio), we aimed to assess its association with gallstone prevalence. Methods We analyzed data from 2,692 participants in the NHANES 2017–2020 dataset. Gallstones were identified through self-reported data, which may introduce bias in the diagnosis. This limitation should be considered when interpreting the results. Logistic regression modelling, smoothed curve fitting and threshold effect analysis assessed the association between CMI and gallstones. Result Higher CMI was significantly associated with an increased risk of gallstones (OR = 1.90, 95% CI: 1.37–2.62, P < 0.0001). A threshold effect was observed at CMI = 0.85, below which risk increased significantly (OR = 2.62, 95% CI:1.34–5.12, P = 0.0049), but became non-significant above this value. The association was stronger in women. Conclusion Our findings support the use of CMI as a potential predictive marker for gallstone risk, suggesting its integration into clinical assessments for early detection and prevention.https://doi.org/10.1186/s12876-025-03777-3NHANESCross-sectional studyGallstonesCardiometabolic indexTyG index |
| spellingShingle | Huachao Zheng Bo Wu Caixiang Zhuang Jiesheng Mao Min li Yuncheng Luo Lidong Huang Sisi Lin Feiyang Zhao Yiren Hu Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 BMC Gastroenterology NHANES Cross-sectional study Gallstones Cardiometabolic index TyG index |
| title | Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 |
| title_full | Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 |
| title_fullStr | Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 |
| title_full_unstemmed | Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 |
| title_short | Cardiometabolic index as a predictor of gallstone risk: evidence from NHANES 2017–2020 |
| title_sort | cardiometabolic index as a predictor of gallstone risk evidence from nhanes 2017 2020 |
| topic | NHANES Cross-sectional study Gallstones Cardiometabolic index TyG index |
| url | https://doi.org/10.1186/s12876-025-03777-3 |
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