Commentary: Triclabendazole induces pyroptosis by activating caspase-3 to cleave GSDME in breast cancer cells

Commentary: Triclabendazole induces pyroptosis by activating caspase-3 to cleave GSDME in breast cancer cells

Saved in:

Bibliographic Details
Main Authors:	Jie Guo, Wen-Long Peng, Chen-Guang Li, Yu-Long Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	MCF-7 cells gasdermin E caspase-3 pyroptosis breast cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1583920/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Caspase 3 proteolytically inactivates gasdermin Ec and inhibits pyroptosis in an early vertebrate
by: Xin Tian, et al.
Published: (2025-06-01)

Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study
by: Lalitha Tanjore Arunachalam, et al.
Published: (2024-11-01)

Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway
by: Tingting Pan, et al.
Published: (2025-07-01)

Pyroptosis and its therapeutic potential
by: I. A. Odintsova, et al.
Published: (2024-07-01)

Triggering Pyroptosis in Cancer
by: Daniel E. Johnson, et al.
Published: (2025-02-01)

Impact of Caspase3/GSDME-Mediated Pyroptosis on Tumor Immune Microenvironment and Clinical Prognosis Across Multiple Cancers
by: Huang Y, et al.
Published: (2024-11-01)

Etoposide Treatment of Cancer Cell Lines Results in Nuclear Localisation of Cleaved Gasdermin D
by: Soukaina Imlilss, et al.
Published: (2024-12-01)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer
by: Xinda Yang, et al.
Published: (2025-08-01)

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation
by: Ke Jiang, et al.
Published: (2024-11-01)

Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells
by: Yuandong Luo, et al.
Published: (2025-04-01)

Pterostilbene induces pyroptosis in mouse breast cancer cells through the caspase-3/Gasdermin E signaling pathway and reshapes the tumor immune microenvironment
by: Xiaoxia Huang, et al.
Published: (2025-09-01)

Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy
by: Hao Yin, et al.
Published: (2024-12-01)

Gemfibrozil mitigates caspase-11-driven myocardial pyroptosis in ischemia/reperfusion injury in mice
by: Tetsuro Marunouchi, et al.
Published: (2025-06-01)

Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis
by: Jian Liu, et al.
Published: (2024-12-01)

Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus
by: Lihan Liu, et al.
Published: (2025-04-01)

Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions
by: Ya Liu, et al.
Published: (2024-12-01)

Applications of pyroptosis activators in tumor immunotherapy
by: Xin Bao, et al.
Published: (2024-10-01)

RAD51 modulates in nasopharyngeal carcinoma cells by regulating Caspase-8-mediated pyroptosis
by: Fuchuan Xie, et al.
Published: (2025-07-01)

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells
by: Guanghui Zi, et al.
Published: (2024-12-01)

Discovery of pyroptosis-inducing natural products in neuroblastomas: computational studies with experimental validation
by: Beni Lestari, et al.
Published: (2025-07-01)

Piperine protects against cerebral ischemic injury by regulating the Caspase-1-mediated pyroptosis pathway
by: Jiayuan Lu, et al.
Published: (2025-07-01)

Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats
by: Guofang Zhang, et al.
Published: (2025-06-01)

Potent ferroptosis agent RSL3 induces cleavage of Pyroptosis-Specific gasdermins in Cancer cells
by: William G. Herrick, et al.
Published: (2025-07-01)

Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells
by: Xiaobo Zhang, et al.
Published: (2025-05-01)

Corrigendum: Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis
by: Christian Stoess, et al.
Published: (2024-10-01)

Caspase-14-like Proteases: An Epidermal Caspase and Its Evolutionarily Ancient Relatives
by: Leopold Eckhart, et al.
Published: (2025-06-01)

Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E‐Dependent Pyroptosis in Pancreatic Cancer Cells
by: Jiaqi Tan, et al.
Published: (2025-07-01)

Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities
by: Rui Miao, et al.
Published: (2025-04-01)

Caspase-1 knockout disrupts pyroptosis and protects photoreceptor cells from photochemical damage
by: Xiaoping Yu, et al.
Published: (2024-12-01)

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis
by: Chaoxu Liu, et al.
Published: (2025-08-01)

Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis
by: Georgia Gunner, et al.
Published: (2025-10-01)

From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge?
by: Fang J, et al.
Published: (2025-03-01)

Genistein inhibits the release of pro-inflammatory substances from macrophages by suppressing potassium loss- and ROS-mediated caspase-1/gasdermin D pathway activation and pyroptotic cell lysis
by: Meimei Yang, et al.
Published: (2024-12-01)

Engineering a drug-inducible pyroptosis platform enables precise tumor suppression in colorectal cancer
by: Xiang Yao, et al.
Published: (2025-12-01)

Quercetin as a radiosensitizer for enhanced efficacy of radiotherapy in MCF-7 breast cancer cells
by: Mohammad Banparvar, et al.
Published: (2024-12-01)

Esketamine mitigates endotoxin-induced acute lung injury by suppressing caspase-11-driven pyroptosis
by: Yunfei Bao, et al.
Published: (2025-07-01)

Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates
by: Zikun Tu, et al.
Published: (2025-05-01)

Nanomedicine-induced pyroptosis for anti-tumor immunotherapy: Mechanism analysis and application prospects
by: Yuelin Huang, et al.
Published: (2025-07-01)

The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis
by: Xiaoxi Fan, et al.
Published: (2025-03-01)

Kukoamine B regulates pyroptosis mediated by NLRP3/Caspase-1/GSDMD pathway to alleviate lipopolysaccharide-induced macrophage inflammation
by: NING Pu, et al.
Published: (2024-07-01)