Gut microbiota dysontogeniya in infants as a factor in the development of atopy
The article describes the modern views on the relationship between altered development of gut microbiota in infants and the risk of developing atopic diseases (atopic dermatitis and bronchial asthma). The studies of genetic susceptibility to atopy and the influence of epigenetic mechanisms involved...
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| Format: | Article |
| Language: | Russian |
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Union of pediatricians of Russia
2019-06-01
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| Series: | Педиатрическая фармакология |
| Subjects: | |
| Online Access: | https://www.pedpharma.ru/jour/article/view/1721 |
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| author | Irina A. Belyaeva Elena P. Bombardirova Leyla S. Namazova-Baranova Elena A. Vishneva Pavel E. Sadchikov |
| author_facet | Irina A. Belyaeva Elena P. Bombardirova Leyla S. Namazova-Baranova Elena A. Vishneva Pavel E. Sadchikov |
| author_sort | Irina A. Belyaeva |
| collection | DOAJ |
| description | The article describes the modern views on the relationship between altered development of gut microbiota in infants and the risk of developing atopic diseases (atopic dermatitis and bronchial asthma). The studies of genetic susceptibility to atopy and the influence of epigenetic mechanisms involved in the regulation of gene expression responsible for the hyperproduction of immunoglobulin E are discussed. The characteristics of the microbiota of infants with already developed atopic diseases and children at risk of atopy are analyzed. In infants who subsequently developed atopy, the composition of gut microbiota at the birth is characterized by a reduced abundance of bifidobacteria and high content of potentially pathogenic microorganisms. The triggering role of active metabolites of altered microbiota on the differentiation of T-regulatory cells has been established. A preventive effect of optimal breastfeeding has been confirmed: meta-analyzes of recent studies indicate a link between the duration of breastfeeding and a decrease in the frequency of bronchial asthma. The microbiota of breast milk contributes to the proper development of the infant’s microbiota, determines its diversity and immunomodulating action. On the basis of the conducted research, methods of targeted correction of the intestinal microbiota in children with risk of atopy can be developed. |
| format | Article |
| id | doaj-art-bc0e2ba49ee94d4d97bdca34e97f3b82 |
| institution | Kabale University |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2019-06-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-bc0e2ba49ee94d4d97bdca34e97f3b822025-08-20T03:39:29ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892019-06-01162919610.15690/pf.v16i2.20051641Gut microbiota dysontogeniya in infants as a factor in the development of atopyIrina A. Belyaeva0Elena P. Bombardirova1Leyla S. Namazova-Baranova2Elena A. Vishneva3Pavel E. Sadchikov4Pirogov Russian National Research Medical University; Morozov Children’s City Clinical HospitalNational Medical Research Center for Children’s HealthPirogov Russian National Research Medical University; Central Clinical Hospital of the Russian Academy of SciencesPirogov Russian National Research Medical University; National Medical Research Center for Children’s Health; Central Clinical Hospital of the Russian Academy of SciencesPirogov Russian National Research Medical UniversityThe article describes the modern views on the relationship between altered development of gut microbiota in infants and the risk of developing atopic diseases (atopic dermatitis and bronchial asthma). The studies of genetic susceptibility to atopy and the influence of epigenetic mechanisms involved in the regulation of gene expression responsible for the hyperproduction of immunoglobulin E are discussed. The characteristics of the microbiota of infants with already developed atopic diseases and children at risk of atopy are analyzed. In infants who subsequently developed atopy, the composition of gut microbiota at the birth is characterized by a reduced abundance of bifidobacteria and high content of potentially pathogenic microorganisms. The triggering role of active metabolites of altered microbiota on the differentiation of T-regulatory cells has been established. A preventive effect of optimal breastfeeding has been confirmed: meta-analyzes of recent studies indicate a link between the duration of breastfeeding and a decrease in the frequency of bronchial asthma. The microbiota of breast milk contributes to the proper development of the infant’s microbiota, determines its diversity and immunomodulating action. On the basis of the conducted research, methods of targeted correction of the intestinal microbiota in children with risk of atopy can be developed.https://www.pedpharma.ru/jour/article/view/1721atopyintestinal microbiotainfantsbreastfeedingprobiotics |
| spellingShingle | Irina A. Belyaeva Elena P. Bombardirova Leyla S. Namazova-Baranova Elena A. Vishneva Pavel E. Sadchikov Gut microbiota dysontogeniya in infants as a factor in the development of atopy Педиатрическая фармакология atopy intestinal microbiota infants breastfeeding probiotics |
| title | Gut microbiota dysontogeniya in infants as a factor in the development of atopy |
| title_full | Gut microbiota dysontogeniya in infants as a factor in the development of atopy |
| title_fullStr | Gut microbiota dysontogeniya in infants as a factor in the development of atopy |
| title_full_unstemmed | Gut microbiota dysontogeniya in infants as a factor in the development of atopy |
| title_short | Gut microbiota dysontogeniya in infants as a factor in the development of atopy |
| title_sort | gut microbiota dysontogeniya in infants as a factor in the development of atopy |
| topic | atopy intestinal microbiota infants breastfeeding probiotics |
| url | https://www.pedpharma.ru/jour/article/view/1721 |
| work_keys_str_mv | AT irinaabelyaeva gutmicrobiotadysontogeniyaininfantsasafactorinthedevelopmentofatopy AT elenapbombardirova gutmicrobiotadysontogeniyaininfantsasafactorinthedevelopmentofatopy AT leylasnamazovabaranova gutmicrobiotadysontogeniyaininfantsasafactorinthedevelopmentofatopy AT elenaavishneva gutmicrobiotadysontogeniyaininfantsasafactorinthedevelopmentofatopy AT pavelesadchikov gutmicrobiotadysontogeniyaininfantsasafactorinthedevelopmentofatopy |